scholarly journals Thermally triggered theranostics for pancreatic cancer therapy

Nanoscale ◽  
2017 ◽  
Vol 9 (34) ◽  
pp. 12735-12745 ◽  
Author(s):  
Maryam Malekigorji ◽  
Mohanad Alfahad ◽  
Paul Kong Thoo Lin ◽  
Stefanie Jones ◽  
Anthony Curtis ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Drug Release ◽  
Laser Irradiation ◽  
Nanoparticle Surface ◽  
Cancer Models ◽  
Hybrid Nanoparticle ◽  
Pancreatic Cancer Therapy ◽  
Thermally Triggered

Heat initiated drug release from a hybrid nanoparticle surface after laser irradiation in pancreatic cancer models.

scholarly journals Sequentially Triggered Nanoparticles with Tumor Penetration and Intelligent Drug Release for Pancreatic Cancer Therapy

2018 ◽  
Vol 5 (5) ◽  
pp. 1701070 ◽  
Author(s):  
Xi He ◽  
Xinli Chen ◽  
Lisha Liu ◽  
Yu Zhang ◽  
Yifei Lu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Drug Release ◽  
Tumor Penetration ◽  
Pancreatic Cancer Therapy

scholarly journals Potential of hybrid iron oxide–gold nanoparticles as thermal triggers for pancreatic cancer therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (97) ◽  
pp. 95044-95054 ◽  
Author(s):  
Adeolu Oluwasanmi ◽  
Maryam Malekigorji ◽  
Stefanie Jones ◽  
Anthony Curtis ◽  
Clare Hoskins
Keyword(s):  
Pancreatic Cancer ◽  
Gold Nanoparticles ◽  
Iron Oxide ◽  
Cancer Therapy ◽  
Laser Irradiation ◽  
Hybrid Nanoparticles ◽  
Future Application ◽  
Pancreatic Cancer Therapy

Laser irradiation of hybrid nanoparticles in biological conditions for future application in pancreatic cancer therapy.

Theranostic nanoparticles enabling the release of phosphorylated gemcitabine for advanced pancreatic cancer therapy

2020 ◽  
Vol 8 (12) ◽  
pp. 2410-2417
Author(s):  
Qingbing Wang ◽  
Xingjun Zhu ◽  
Zhiyuan Wu ◽  
Tao Sun ◽  
Wei Huang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Drug Resistance ◽  
Cancer Therapy ◽  
Drug Release ◽  
Advanced Pancreatic Cancer ◽  
Controlled Drug Release ◽  
Theranostic Nanoparticles ◽  
Pancreatic Cancer Therapy

A lanthanide-based visualizable photothermal controlled drug release nanosystem was developed to overcome the drug resistance of gemcitabine for pancreatic cancer.

scholarly journals RNAi-Based Approaches for Pancreatic Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1638
Author(s):  
Min Ju Kim ◽  
Hyeyoun Chang ◽  
Gihoon Nam ◽  
Youngji Ko ◽  
Sun Hwa Kim ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Therapeutic Potential ◽  
Treatment Strategies ◽  
Tumor Formation ◽  
Cancer Models ◽  
Tumor Delivery ◽  
Pancreatic Cancer Therapy ◽  
Interfering Rna ◽  
Patient Survival Rate

Pancreatic cancer is one of the most lethal forms of cancer, predicted to be the second leading cause of cancer-associated death by 2025. Despite intensive research for effective treatment strategies and novel anticancer drugs over the past decade, the overall patient survival rate remains low. RNA interference (RNAi) is capable of interfering with expression of specific genes and has emerged as a promising approach for pancreatic cancer because genetic aberrations and dysregulated signaling are the drivers for tumor formation and the stromal barrier to conventional therapy. Despite its therapeutic potential, RNA-based drugs have remaining hurdles such as poor tumor delivery and susceptibility to serum degradation, which could be overcome with the incorporation of nanocarriers for clinical applications. Here we summarize the use of small interfering RNA (siRNA) and microRNA (miRNA) in pancreatic cancer therapy in preclinical reports with approaches for targeting either the tumor or tumor microenvironment (TME) using various types of nanocarriers. In these studies, inhibition of oncogene expression and induction of a tumor suppressive response in cancer cells and surrounding immune cells in TME exhibited a strong anticancer effect in pancreatic cancer models. The review discusses the remaining challenges and prospective strategies suggesting the potential of RNAi-based therapeutics for pancreatic cancer.

MDM2 Inhibitors for Pancreatic Cancer Therapy

2010 ◽  
Vol 999 (999) ◽  
pp. 1-9
Author(s):  
A. S. Azmi ◽  
P. A. Philip ◽  
K. Almhanna ◽  
F. W. Beck ◽  
Z. K. Kafri ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Pancreatic Cancer Therapy

290 Novel Mcl-1 inhibitors for pancreatic cancer therapy

2010 ◽  
Vol 8 (7) ◽  
pp. 94
Author(s):  
Z. Nikolovska-Coleska ◽  
N. Bajwa ◽  
M. Liu ◽  
A. Azmi ◽  
J. Stuckey ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Pancreatic Cancer Therapy

Invadopodia: A potential target for pancreatic cancer therapy

2021 ◽  
Vol 159 ◽  
pp. 103236
Author(s):  
Yan Luo ◽  
Jisheng Hu ◽  
Yong Liu ◽  
Le Li ◽  
Yilong Li ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Potential Target ◽  
Pancreatic Cancer Therapy

scholarly journals Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy

2016 ◽  
Vol 15 (11) ◽  
pp. 2609-2619 ◽  
Author(s):  
Xiaojuan Wu ◽  
Yang Cao ◽  
Hui Xiao ◽  
Chenglong Li ◽  
Jiayuh Lin
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Pancreatic Cancer Therapy
Sign in / Sign up

Export Citation Format

Share Document