On-demand curing of polydimethylsiloxane (PDMS) using the photothermal effect of gold nanoparticles

Nanoscale ◽  
2017 ◽  
Vol 9 (25) ◽  
pp. 8555-8559 ◽  
Author(s):  
R. Joseph Fortenbaugh ◽  
Benjamin J. Lear
Keyword(s):  
Gold Nanoparticles ◽  
Photothermal Effect ◽  
On Demand

Preparation and in vitro evaluation of doxorubicin loaded alendronate modified hollow gold nanoparticles for bone-targeted chemo-photothermal therapy

2020 ◽  
Vol 10 (11) ◽  
pp. 1950-1959
Author(s):  
Lei Yang ◽  
Yumin Hu ◽  
Yuanfen Liu ◽  
Yanyan Liu ◽  
Si Miao ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Bone Tumors ◽  
Drug Loading ◽  
Photothermal Effect ◽  
Osteosarcoma Cells ◽  
Hollow Gold Nanoparticles ◽  
Human Osteosarcoma Cells

The treatment of malignant bone tumors (including primary bone tumors and metastatic bone tumors) has always been a clinical challenge. The purpose of this study is to design a bone-targeted nano-carrier with photothermal effect to achieve chemo-photothermal therapy (CPT), which allows the minimal use of photothermal agents and chemical drugs to target bone tumors. Alendronate modified hollow gold nanoparticles (HGNPs- ALN) were synthesized using mercapto polyethylene glycol carboxyl (SH-PEG2000-COOH) as the connecting arm, fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM) data show that HGNPs-ALN with a particle size of about 80 nm has been successfully synthesized. The hydroxyapatite affinity experiment in vitro indicated that HGNPs-ALN exhibited a high affinity to bone. In addition, the temperature of HGNPs-ALN under near-infrared laser irradiation can rise to 53 °C, which can achieve effective photothermal therapy for bone tumors. Bone-targeted hollow gold nanoparticles (DOX@HGNPs-ALN) loaded with doxorubicin hydrochloride (DOX) were synthesized by one-pot method. By comparing the stability and drug loading of HGNPs-ALN, it was concluded that the optimal mass ratio of HGNPs-ALN (calculated by the amount of gold) to DOX was about 1:2. HGNPs-ALN and DOX@HGNPs-ALN both have good photothermal stability and photothermal transformation properties, and confirmed the safety of HGNPs on human osteosarcoma cells. MTT experiments showed that DOX@HGNPs-ALN had the strongest killing effect on MG-63 osteosarcoma cells under laser irradiation (the killing rate is about 65%). According to these results, it can be considered that DOX@HGNPs-ALN has the potential of CPT synergistic targeting therapy for bone tumors.

scholarly journals Gold Nanorod Bioconjugates for Active Tumor Targeting and Photothermal Therapy

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Hadiyah N. Green ◽  
Dmitry V. Martyshkin ◽  
Cynthia M. Rodenburg ◽  
Eben L. Rosenthal ◽  
Sergey B. Mirov
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Malignant Tumors ◽  
Photothermal Effect ◽  
Specific Antibodies ◽  
Before And After ◽  
Egfr Antibody

The mastery of active tumor targeting is a great challenge in near infrared photothermal therapy (NIRPTT). To improve efficiency for targeted treatment of malignant tumors, we modify the technique of conjugating gold nanoparticles to tumor-specific antibodies. Polyethylene glycol-coated (PEGylated) gold nanorods (GNRs) were fabricated and conjugated to an anti-EGFR antibody. We characterized the conjugation efficiency of the GNRs by comparing the efficiency of antibody binding and the photothermal effect of the GNRs before and after conjugation. We demonstrate that the binding efficiency of the antibodies conjugated to the PEGylated GNRs is comparable to the binding efficiency of the unmodified antibodies and 33.9% greater than PEGylated antibody-GNR conjugates as reported by Liao and Hafner (2005). In addition, cell death by NIRPTT was sufficient to kill nearly 90% of tumor cells, which is comparable to NIRPTT with GNRs alone confirming that NIRPTT using GNRs is not compromised by conjugation of GNRs to antibodies.

Laser annealing of gold nanoparticles thin film using photothermal effect

2009 ◽  
Vol 86 (4-6) ◽  
pp. 865-867 ◽  
Author(s):  
Yi-Ting Cheng ◽  
Rouh-Huey Uang ◽  
Yu-Ming Wang ◽  
Kuo-Chan Chiou ◽  
Tzong-Ming Lee
Keyword(s):  
Thin Film ◽  
Gold Nanoparticles ◽  
Laser Annealing ◽  
Photothermal Effect

Interfacial healing of carbon fiber composites in the presence of gold nanoparticles as localized “nano-heaters”

RSC Advances ◽  
2015 ◽  
Vol 5 (8) ◽  
pp. 5680-5685 ◽  
Author(s):  
Zhenxing Cao ◽  
Rongguo Wang ◽  
Lifeng Hao ◽  
Weicheng Jiao ◽  
Fan Yang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Carbon Fiber ◽  
Local Heating ◽  
Fiber Composites ◽  
Photothermal Effect ◽  
Carbon Fiber Composites ◽  
Au Nps

In this paper, interfacial healing was achieved in carbon fiber composites via local heating generated by photothermal effect of gold nanoparticles (Au NPs).

scholarly journals Continuous In-Flight Synthesis for On-Demand Delivery of Ligand-Free Colloidal Gold Nanoparticles

Nano Letters ◽  
2017 ◽  
Vol 17 (3) ◽  
pp. 1336-1343 ◽  
Author(s):  
Paul Maguire ◽  
David Rutherford ◽  
Manuel Macias-Montero ◽  
Charles Mahony ◽  
Colin Kelsey ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Colloidal Gold ◽  
On Demand ◽  
Colloidal Gold Nanoparticles ◽  
Ligand Free
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