Biocompatible conjugated polymer nanoparticles for highly efficient photoacoustic imaging of orthotopic brain tumors in the second near-infrared window

2017 ◽  
Vol 4 (6) ◽  
pp. 1151-1156 ◽  
Author(s):  
Bing Guo ◽  
Zonghai Sheng ◽  
Kenry Kenry ◽  
Dehong Hu ◽  
Xiangwei Lin ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Conjugated Polymer ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Polymer Nanoparticles ◽  
High Signal ◽  
Highly Efficient ◽  
Conjugated Polymer Nanoparticles ◽  
Good Penetration ◽  
Good Biocompatibility

NIR II conjugated polymer nanoparticles with good biocompatibility, excellent photoacoustic stability and high imaging contrast are formulated, which allows highly efficient imaging of orthotopic brain tumors with a high signal/background ratio and a good penetration depth.

scholarly journals Multifunctional conjugated polymer nanoparticles for photoacoustic-based multimodal imaging and cancer photothermal therapy

2019 ◽  
Vol 12 (03) ◽  
pp. 1930001 ◽  
Author(s):  
Xiaoju Men ◽  
Zhen Yuan
Keyword(s):  
Conjugated Polymer ◽  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
Photoacoustic Imaging ◽  
Biological Tissues ◽  
Polymer Nanoparticles ◽  
Imaging Method ◽  
Conjugated Polymer Nanoparticles ◽  
Good Biocompatibility ◽  
Cancer Theranostics

Photoacoustic imaging (PAI) is a hybrid imaging method based on photoacoustic (PA) effects, which is able to capture the structure, function, and molecular information of biological tissues with high resolution. To date, therapeutic techniques under the guidance of PAI have provided new strategies for accurate diagnosis and precise treatment of tumors. In particular, conjugated polymer nanoparticles have been extensively inspected for PA-based cancer theranostics largely due to their superior optical properties such as tunable spectrum and large absorption coefficient and their good biocompatibility, and abundant functional groups. This mini-review mainly focuses on the recent advances toward the development of novel conjugated polymer nanoparticles for PA-based multimodal imaging and cancer photothermal therapy.

Theranostic Near-Infrared-Active Conjugated Polymer Nanoparticles

ACS Nano ◽  
2021 ◽  
Author(s):  
Miao Zhao ◽  
Edward Leggett ◽  
Struan Bourke ◽  
Souzana Poursanidou ◽  
Sadie Carter-Searjeant ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Near Infrared ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles

Far-red/near-infrared fluorescent conjugated polymer nanoparticles with size-dependent chirality and cell imaging applications

2015 ◽  
Vol 6 (21) ◽  
pp. 3962-3969 ◽  
Author(s):  
Chunhui Dai ◽  
Dongliang Yang ◽  
Wenjie Zhang ◽  
Biqing Bao ◽  
Yixiang Cheng ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Near Infrared ◽  
Cell Imaging ◽  
Polymer Nanoparticles ◽  
Size Dependent ◽  
Conjugated Polymer Nanoparticles ◽  
Nanoparticle Sizes

We prepared a series of novel chiral far-red/near-infrared fluorescent CPNs with different nanoparticle sizes, which show size-dependent chirality and are successfully employed for cell imaging.

scholarly journals Fluorescence Imaging: Bright Far-Red/Near-Infrared Conjugated Polymer Nanoparticles for In Vivo Bioimaging (Small 18/2013)

Small ◽  
2013 ◽  
Vol 9 (18) ◽  
pp. 3092-3092 ◽  
Author(s):  
Dan Ding ◽  
Jie Liu ◽  
Guangxue Feng ◽  
Kai Li ◽  
Yong Hu ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Conjugated Polymer ◽  
Near Infrared ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles

ROS-Responsive and active targeted drug delivery based on conjugated polymer nanoparticles for synergistic chemo-/photodynamic therapy

2021 ◽  
Author(s):  
Ziqi Zhang ◽  
Zhuanning Lu ◽  
Qiong Yuan ◽  
Chen Zhang ◽  
Yanli Tang
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Targeted Drug Delivery ◽  
Conjugated Polymer ◽  
Polymer Nanoparticles ◽  
Active Targeting ◽  
Highly Efficient ◽  
Conjugated Polymer Nanoparticles ◽  
Targeted Drug

A biocompatible and ROS-responsive drug delivery nanocarrier iRGD-BDOX@CPNs with active targeting was constructed for highly efficient chemo-/photodynamic (PDT) synergistic therapy.

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