Directed assembly of metal nanoparticles in polymer bilayers

2018 ◽  
Vol 3 (2) ◽  
pp. 390-396 ◽  
Author(s):  
Su-Wen Hsu ◽  
Yuhan Long ◽  
Aatheya G. Subramanian ◽  
Andrea R. Tao
Keyword(s):  
Metal Nanoparticles ◽  
Self Assembly ◽  
Directed Assembly ◽  
Nanocomposite Materials ◽  
Layer By Layer ◽  
Polymer Bilayers

The integration of layer-by-layer (LbL) and self-assembly methods has the potential to achieve precision assembly of nanocomposite materials.

scholarly journals Electric-Field-Directed Self-Assembly of Active Enzyme-Nanoparticle Structures

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Alexander P. Hsiao ◽  
Michael J. Heller
Keyword(s):  
Electric Field ◽  
Self Assembly ◽  
Microelectrode Array ◽  
Glucose Sensor ◽  
Directed Assembly ◽  
Passive Layer ◽  
Higher Order ◽  
Significant Loss ◽  
Layer By Layer ◽  
Multilayered Structures

A method is presented for the electric-field-directed self-assembly of higher-order structures composed of alternating layers of biotin nanoparticles and streptavidin-/avidin-conjugated enzymes carried out on a microelectrode array device. Enzymes included in the study were glucose oxidase (GOx), horseradish peroxidase (HRP), and alkaline phosphatase (AP); all of which could be used to form a light-emitting microscale glucose sensor. Directed assembly included fabricating multilayer structures with 200 nm or 40 nm GOx-avidin-biotin nanoparticles, with AP-streptavidin-biotin nanoparticles, and with HRP-streptavidin-biotin nanoparticles. Multilayered structures were also fabricated with alternate layering of HRP-streptavidin-biotin nanoparticles and GOx-avidin-biotin nanoparticles. Results showed that enzymatic activity was retained after the assembly process, indicating that substrates could still diffuse into the structures and that the electric-field-based fabrication process itself did not cause any significant loss of enzyme activity. These methods provide a solution to overcome the cumbersome passive layer-by-layer assembly methods to efficiently fabricate higher-order active biological and chemical hybrid structures that can be useful for creating novel biosensors and drug delivery nanostructures, as well as for diagnostic applications.

scholarly journals Construction of Chitosan/Alginate Nano-Drug Delivery System for Improving Dextran Sodium Sulfate-Induced Colitis in Mice

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1884
Author(s):  
Mengfei Jin ◽  
Shangyong Li ◽  
Yanhong Wu ◽  
Dandan Li ◽  
Yantao Han
Keyword(s):  
Self Assembly ◽  
Average Diameter ◽  
Mucosal Healing ◽  
Plga Nanoparticles ◽  
Narrow Particle Size Distribution ◽  
Layer By Layer ◽  
Systemic Side Effects ◽  
Assembly Technology ◽  
The Fourier Transform ◽  
Polyelectrolyte Film

(1) Background: In the treatment of ulcerative colitis (UC), accurate delivery and release of anti-inflammatory drugs to the site of inflammation can reduce systemic side effects. (2) Methods: We took advantage of this goal to prepare resveratrol-loaded PLGA nanoparticles (RES-PCAC-NPs) by emulsification solvent volatilization. After layer-by-layer self-assembly technology, we deposited chitosan and alginate to form a three-layer polyelectrolyte film. (3) Results: It can transport nanoparticles through the gastric environment to target inflammation sites and slowly release drugs at a specific pH. The resulting RES-PCAC-NPs have an ideal average diameter (~255 nm), a narrow particle size distribution and a positively charged surface charge (~13.5 mV). The Fourier transform infrared spectroscopy showed that resveratrol was successfully encapsulated into PCAC nanoparticles, and the encapsulation efficiency reached 87.26%. In addition, fluorescence imaging showed that RES-PCAC-NPs with positive charges on the surface can effectively target and accumulate in the inflammation site while continuing to penetrate downward to promote mucosal healing. Importantly, oral RES-PCAC-NPs treatment in DSS-induced mice was superior to other results in significantly improved inflammatory markers of UC. (4) Conclusions: Our results strongly prove that RES-PCAC-NPs can target the inflamed colon for maximum efficacy, and this oral pharmaceutical formulation can represent a promising formulation in the treatment of UC.

scholarly journals Photoacoustics for listening to Metal Nanoparticles Super-Aggregates

2021 ◽  
Author(s):  
Roberto Li Voti ◽  
Grigore Leahu ◽  
Concita Sibilia ◽  
Roberto Matassa ◽  
Giuseppe Familiari ◽  
...  
Keyword(s):  
Metal Nanoparticles ◽  
Size Distribution ◽  
Packing Density ◽  
Self Assembly ◽  
Détection Signal ◽  
Photoacoustic Detection ◽  
New Strategy ◽  
Aggregate Packing ◽  
Detection Signal

Photoacoustic detection signal has been used to build a new strategy to determine the mesoscale self-assembly of metal nanoparticles in terms of size distribution and aggregate packing density (metal nanoparticles...

Graphene-Based Multilayers Constructed from Layer-by-Layer Self-Assembly Techniques

2014 ◽  
Vol 14 (2) ◽  
pp. 1145-1153 ◽  
Author(s):  
Bing Yu ◽  
Xiaomian Liu ◽  
Hailin Cong ◽  
Hua Yuan ◽  
Dong Wang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Layer By Layer

Layer-by-layer self-assembly of PDDA/PWA–Nafion composite membranes for direct methanol fuel cells

2010 ◽  
Vol 46 (9) ◽  
pp. 1434 ◽  
Author(s):  
Meng Yang ◽  
Shanfu Lu ◽  
Jinlin Lu ◽  
San Ping Jiang ◽  
Yan Xiang
Keyword(s):  
Fuel Cells ◽  
Self Assembly ◽  
Direct Methanol Fuel Cells ◽  
Composite Membranes ◽  
Layer By Layer ◽  
Direct Methanol ◽  
Methanol Fuel Cells
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