scholarly journals Enabling precision manufacturing of active pharmaceutical ingredients: workflow for seeded cooling continuous crystallisations

2018 ◽  
Vol 3 (3) ◽  
pp. 518-549 ◽  
Author(s):  
Cameron J. Brown ◽  
Thomas McGlone ◽  
Stephanie Yerdelen ◽  
Vijay Srirambhatla ◽  
Fraser Mabbott ◽  
...  
Keyword(s):  
Process Design ◽  
Active Pharmaceutical Ingredients ◽  
Precision Manufacturing ◽  
Tight Control ◽  
Pharmaceutical Ingredients ◽  
Crystallisation Process

Presentation and applied case study of a system-wide workflow which supports rapid, systematic and efficient continuous seeded cooling crystallisation process design, with the aim to deliver a robust, consistent process with tight control of particle attributes.

The challenge of improved secretory production of active pharmaceutical ingredients inSaccharomyces cerevisiae: A case study on human insulin analogs

2013 ◽  
Vol 110 (10) ◽  
pp. 2764-2774 ◽  
Author(s):  
Ali Kazemi Seresht ◽  
Eva A. Palmqvist ◽  
Gerd Schluckebier ◽  
Ingrid Pettersson ◽  
Lisbeth Olsson
Keyword(s):  
Human Insulin ◽  
Active Pharmaceutical Ingredients ◽  
Insulin Analogs ◽  
Pharmaceutical Ingredients ◽  
Secretory Production

NPD process in active pharmaceutical ingredients industry: a case study in Iran

2017 ◽  
Vol 12 (1) ◽  
pp. 1
Author(s):  
Noor Mohammad Yaghoobi ◽  
Fatemeh S. Shahmehr ◽  
Seyed Mohammad Sadegh Khaksar ◽  
Narges Safari
Keyword(s):  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

scholarly journals Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

2016 ◽  
Vol 52 (46) ◽  
pp. 7372-7375 ◽  
Author(s):  
Lynne H. Thomas ◽  
Craig Wales ◽  
Chick C. Wilson
Keyword(s):  
Self Assembly ◽  
Single Component ◽  
The Self ◽  
Active Pharmaceutical Ingredients ◽  
Simple Route ◽  
Pharmaceutical Ingredients ◽  
Crystallisation Process ◽  
Polymorphic Forms

A transferable, simple, route to previously elusive and novel polymorphic forms of important active pharmaceutical ingredients is demonstrated using N-heterocyclic co-molecules to influence the self-assembly crystallisation process in a multi-component environment.

NPD process in active pharmaceutical ingredients industry: a case study in Iran

2017 ◽  
Vol 12 (1) ◽  
pp. 1 ◽  
Author(s):  
Fatemeh S. Shahmehr ◽  
Seyed Mohammad Sadegh Khaksar ◽  
Narges Safari ◽  
Noor Mohammad Yaghoobi
Keyword(s):  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

A Case Study of Defects Due to Process-Design Interaction in Nano Scale Technology

2007 ◽  
Author(s):  
Hung-Sung Lin ◽  
Ying-Chin Hou ◽  
Juimei Fu ◽  
Mong-Sheng Wu ◽  
Vincent Huang ◽  
...  
Keyword(s):  
Liquid Crystal ◽  
Circuit Design ◽  
Process Design ◽  
Integrated Circuit ◽  
Photon Emission ◽  
Integrated Circuit Design ◽  
Nano Scale ◽  
Leakage Path ◽  
Related Defect

Abstract The difficulties in identifying the precise defect location and real leakage path is increasing as the integrated circuit design and process have become more and more complicated in nano scale technology node. Most of the defects causing chip leakage are detectable with only one of the FA (Failure Analysis) tools such as LCD (Liquid Crystal Detection) or PEM (Photon Emission Microscope). However, due to marginality of process-design interaction some defects are often not detectable with only one FA tool [1][2]. This paper present an example of an abnormal power consumption process-design interaction related defect which could only be detected with more advanced FA tools.

Reversed-Phase High Performance Liquid Chromatographic Analysis of Three First Line Anti-Tuberculosis Drugs

2019 ◽  
Vol 69 (12) ◽  
pp. 3590-3592
Author(s):  
Nela Bibire ◽  
Romeo Iulian Olariu ◽  
Luminita Agoroaei ◽  
Madalina Vieriu ◽  
Alina Diana Panainte ◽  
...  
Keyword(s):  
High Performance ◽  
Biological Fluids ◽  
Gradient Elution ◽  
High Performance Liquid Chromatographic ◽  
Reversed Phase ◽  
Assay Method ◽  
Active Pharmaceutical Ingredients ◽  
First Line ◽  
Pharmaceutical Ingredients ◽  
Liquid Chromatographic

Active pharmaceutical ingredients such as isoniazid, pyrazinamide and rifampicin are among the most important first-line anti-tuberculosis drugs. A simple, rapid and sensitive reversed phase-high performance liquid chromatographic assay method for the simultaneous determination of isoniazid, pyrazinamide and rifampicin has been developed. Separation of the interest compounds was achieved in a 10 min chromatographic run in gradient elution mode on a Zorbax SB-C18 stainless steel column (150 � 4 mm, 5 mm) using a guard column containing the same stationary phase. The gradient elution was carried out with a mobile phase of 10% CH3CN aqueous solution for channel A and 50% CH3CN in pH = 6.8 phosphate buffer (20 mM), to which 1.5 mL triethylamine were added for channel B. Quantification of the analyzed substances was carried out spectrophotometrically at 269 nm. Detection limits of 0.48 mg/L for isoniazid, 0.52 mg/L for pyrazinamide and 0.48 mg/L for rifampicin were established for the developed assay method. The present work showed that the proposed analysis method was advantageous for simple and rapid analysis of the active pharmaceutical ingredients in pharmaceuticals and biological fluids.

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