scholarly journals Recent advances in combretastatin based derivatives and prodrugs as antimitotic agents

MedChemComm ◽  
2017 ◽  
Vol 8 (8) ◽  
pp. 1592-1603 ◽  
Author(s):  
Zaki S. Seddigi ◽  
M. Shaheer Malik ◽  
A Prasanth Saraswati ◽  
Saleh A. Ahmed ◽  
Ahmed O. Babalghith ◽  
...  
Keyword(s):  
Drug Development ◽  
Anticancer Drug ◽  
Crucial Role ◽  
Cellular Functions ◽  
Recent Advances ◽  
Promising Target ◽  
Anticancer Drug Development

The dynamic and crucial role of tubulin in different cellular functions rendered it a promising target in anticancer drug development.

Recent advances in pharmacogenetic approaches to anticancer drug development

2004 ◽  
Vol 62 (3) ◽  
pp. 233-253 ◽  
Author(s):  
Nicola F. Smith ◽  
William D. Figg ◽  
Alex Sparreboom
Keyword(s):  
Drug Development ◽  
Anticancer Drug ◽  
Recent Advances ◽  
Anticancer Drug Development

scholarly journals MicroRNA as an Important Target for Anticancer Drug Development

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhiwen Fu ◽  
Liu Wang ◽  
Shijun Li ◽  
Fen Chen ◽  
Kathy Ka-Wai Au-Yeung ◽  
...  
Keyword(s):  
Drug Development ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Tumor Development ◽  
Mrna Translation ◽  
Mirna Expression Profile ◽  
Anticancer Treatment ◽  
The Stability ◽  
Anticancer Drug Development

Cancer has become the second greatest cause of death worldwide. Although there are several different classes of anticancer drugs that are available in clinic, some tough issues like side-effects and low efficacy still need to dissolve. Therefore, there remains an urgent need to discover and develop more effective anticancer drugs. MicroRNAs (miRNAs) are a class of small endogenous non-coding RNAs that regulate gene expression by inhibiting mRNA translation or reducing the stability of mRNA. An abnormal miRNA expression profile was found to exist widely in cancer cell, which induces limitless replicative potential and evading apoptosis. MiRNAs function as oncogenes (oncomiRs) or tumor suppressors during tumor development and progression. It was shown that regulation of specific miRNA alterations using miRNA mimics or antagomirs can normalize the gene regulatory network and signaling pathways, and reverse the phenotypes in cancer cells. The miRNA hence provides an attractive target for anticancer drug development. In this review, we will summarize the latest publications on the role of miRNA in anticancer therapeutics and briefly describe the relationship between abnormal miRNAs and tumorigenesis. The potential of miRNA-based therapeutics for anticancer treatment has been critically discussed. And the current strategies in designing miRNA targeting therapeutics are described in detail. Finally, the current challenges and future perspectives of miRNA-based therapy are conferred.

scholarly journals Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Miao-Miao Zhao ◽  
Wei-Li Yang ◽  
Fang-Yuan Yang ◽  
Li Zhang ◽  
Wei-Jin Huang ◽  
...  
Keyword(s):  
Drug Development ◽  
Cathepsin L ◽  
Human Cells ◽  
New Drugs ◽  
Disease Course ◽  
Promising Target ◽  
First Time

AbstractTo discover new drugs to combat COVID-19, an understanding of the molecular basis of SARS-CoV-2 infection is urgently needed. Here, for the first time, we report the crucial role of cathepsin L (CTSL) in patients with COVID-19. The circulating level of CTSL was elevated after SARS-CoV-2 infection and was positively correlated with disease course and severity. Correspondingly, SARS-CoV-2 pseudovirus infection increased CTSL expression in human cells in vitro and human ACE2 transgenic mice in vivo, while CTSL overexpression, in turn, enhanced pseudovirus infection in human cells. CTSL functionally cleaved the SARS-CoV-2 spike protein and enhanced virus entry, as evidenced by CTSL overexpression and knockdown in vitro and application of CTSL inhibitor drugs in vivo. Furthermore, amantadine, a licensed anti-influenza drug, significantly inhibited CTSL activity after SARS-CoV-2 pseudovirus infection and prevented infection both in vitro and in vivo. Therefore, CTSL is a promising target for new anti-COVID-19 drug development.

Applications of liquid biopsy in the Pharmacological Audit Trail for anticancer drug development

2021 ◽  
Author(s):  
Abhijit Pal ◽  
Rajiv Shinde ◽  
Manuel Selvi Miralles ◽  
Paul Workman ◽  
Johann de Bono
Keyword(s):  
Drug Development ◽  
Anticancer Drug ◽  
Liquid Biopsy ◽  
Audit Trail ◽  
Anticancer Drug Development

scholarly journals Targeting Hedgehog Signalling through the Ubiquitylation Process: The Multiple Roles of the HECT-E3 Ligase Itch

Cells ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 98 ◽  
Author(s):  
Paola Infante ◽  
Ludovica Lospinoso Severini ◽  
Flavia Bernardi ◽  
Francesca Bufalieri ◽  
Lucia Di Marcotullio
Keyword(s):  
E3 Ligase ◽  
Multiple Roles ◽  
Post Translational Modification ◽  
Therapeutic Approaches ◽  
Cellular Functions ◽  
Hedgehog Signalling ◽  
Promising Target ◽  
Important Pathway ◽  
Multiple Levels

Hedgehog signalling (Hh) is a developmental conserved pathway strongly involved in cancers when deregulated. This important pathway is orchestrated by numerous regulators, transduces through distinct routes and is finely tuned at multiple levels. In this regard, ubiquitylation processes stand as essential for controlling Hh pathway output. Although this post-translational modification governs proteins turnover, it is also implicated in non-proteolytic events, thereby regulating the most important cellular functions. The HECT E3 ligase Itch, well known to control immune response, is emerging to have a pivotal role in tumorigenesis. By illustrating Itch specificities on Hh signalling key components, here we review the role of this HECT E3 ubiquitin ligase in suppressing Hh-dependent tumours and explore its potential as promising target for innovative therapeutic approaches.

Non-invasive MRS in new anticancer drug development

1992 ◽  
Vol 5 (5) ◽  
pp. 270-272 ◽  
Author(s):  
Paul Workman ◽  
Ross J. Maxwell ◽  
John R. Griffiths
Keyword(s):  
Drug Development ◽  
Anticancer Drug ◽  
Non Invasive ◽  
Anticancer Drug Development

Drug-induced QTc interval prolongation: A proposal towards an efficient and safe anticancer drug development

2008 ◽  
Vol 44 (4) ◽  
pp. 494-500 ◽  
Author(s):  
Giuseppe Curigliano ◽  
Gianluca Spitaleri ◽  
Howard J. Fingert ◽  
Filippo de Braud ◽  
Cristiana Sessa ◽  
...  
Keyword(s):  
Drug Development ◽  
Anticancer Drug ◽  
Qtc Interval ◽  
Interval Prolongation ◽  
Drug Induced ◽  
Qtc Interval Prolongation ◽  
Anticancer Drug Development
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