scholarly journals Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors

MedChemComm ◽  
2017 ◽  
Vol 8 (5) ◽  
pp. 982-988 ◽  
Author(s):  
Hui Deng ◽  
Tom van der Wel ◽  
Richard J. B. H. N. van den Berg ◽  
Adrianus M. C. H. van den Nieuwendijk ◽  
Freek J. Janssen ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Diacylglycerol Lipase ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Dual Inhibitors

The enantioselective synthesis and structure–activity relationships of deoxy-iminosugar-based triazole ureas as dual inhibitors of DAGLα and ABHD6 were reported.

scholarly journals Comprehensive Analysis of Structure–Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors

2015 ◽  
Vol 58 (24) ◽  
pp. 9742-9753 ◽  
Author(s):  
Freek J. Janssen ◽  
Marc P. Baggelaar ◽  
Jessica J. A. Hummel ◽  
Herman S. Overkleeft ◽  
Benjamin F. Cravatt ◽  
...  
Keyword(s):  
Comprehensive Analysis ◽  
Diacylglycerol Lipase ◽  
Structure Activity Relationships ◽  
Structure Activity
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