Global DNA dynamics of 8-oxoguanine repair by human OGG1 revealed by stopped-flow kinetics and molecular dynamics simulation

2017 ◽  
Vol 13 (10) ◽  
pp. 1954-1966 ◽  
Author(s):  
M. V. Lukina ◽  
V. V. Koval ◽  
A. A. Lomzov ◽  
D. O. Zharkov ◽  
O. S. Fedorova
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulation ◽  
Genomic Dna ◽  
Dynamics Simulation ◽  
Toxic Action ◽  
Stopped Flow ◽  
Dna Dynamics ◽  
Exogenous Agents ◽  
Stopped Flow Kinetics

The toxic action of different endogenous and exogenous agents leads to damage in genomic DNA.

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