A robust, portable and backflow-free micromixing device based on both capillary- and vacuum-driven flows

Lab on a Chip ◽  
2018 ◽  
Vol 18 (2) ◽  
pp. 276-284 ◽  
Author(s):  
Yaguang Zhai ◽  
Anyang Wang ◽  
Domin Koh ◽  
Philip Schneider ◽  
Kwang W. Oh
Keyword(s):  
Point Of Care ◽  
Lab On A Chip ◽  
Great Promise ◽  
Blood Typing ◽  
Chip Testing

A robust, portable and backflow-free micromixing device using capillary-driven bypassing and syringe-assisted vacuum-driven pumping shows great promise for a variety of blood typing assays, agglutination-based assays and point-of-care or lab-on-a-chip testing applications.

‘Off–on’ switchable fluorescent probe for prompt and cost-efficient detection of bacteria

2019 ◽  
Vol 43 (33) ◽  
pp. 13094-13102
Author(s):  
Giorgia Giovannini ◽  
Vladimir Gubala ◽  
Andrew J. Hall
Keyword(s):  
Fluorescent Probe ◽  
Bacterial Infections ◽  
Point Of Care ◽  
Lab On A Chip ◽  
Human Samples ◽  
Efficient Detection ◽  
Prevention And Treatment ◽  
Cost Efficient

The rapid and straightforward detection of bacteria in food and human samples is becoming important, particularly in view of the development of point-of-care devices and lab-on-a-chip tools for prevention and treatment of bacterial infections.

scholarly journals Lab-on-a-Chip Systems for Aptamer-Based Biosensing

Micromachines ◽  
2020 ◽  
Vol 11 (2) ◽  
pp. 220 ◽  
Author(s):  
Niazul I. Khan ◽  
Edward Song
Keyword(s):  
Point Of Care ◽  
Lab On A Chip ◽  
Review Article ◽  
Microfluidic Chips ◽  
High Affinity ◽  
Sensing Platforms ◽  
Personal Medicine ◽  
Paper Based Microfluidics ◽  
Recognition Elements ◽  
Analyte Detection

Aptamers are oligonucleotides or peptides that are selected from a pool of random sequences that exhibit high affinity toward a specific biomolecular species of interest. Therefore, they are ideal for use as recognition elements and ligands for binding to the target. In recent years, aptamers have gained a great deal of attention in the field of biosensing as the next-generation target receptors that could potentially replace the functions of antibodies. Consequently, it is increasingly becoming popular to integrate aptamers into a variety of sensing platforms to enhance specificity and selectivity in analyte detection. Simultaneously, as the fields of lab-on-a-chip (LOC) technology, point-of-care (POC) diagnostics, and personal medicine become topics of great interest, integration of such aptamer-based sensors with LOC devices are showing promising results as evidenced by the recent growth of literature in this area. The focus of this review article is to highlight the recent progress in aptamer-based biosensor development with emphasis on the integration between aptamers and the various forms of LOC devices including microfluidic chips and paper-based microfluidics. As aptamers are extremely versatile in terms of their utilization in different detection principles, a broad range of techniques are covered including electrochemical, optical, colorimetric, and gravimetric sensing as well as surface acoustics waves and transistor-based detection.

Lab-on-a-Chip Device and System for Point-of-Care Applications

2017 ◽  
pp. 87-121
Author(s):  
Tsung-Feng Wu ◽  
Sung Hwan Cho ◽  
Yu-Jui Chiu ◽  
Yu-Hwa Lo
Keyword(s):  
Point Of Care ◽  
Lab On A Chip

Project-Based Learning: Microfluidic Lab-on-a-Chip Point-of-Care Medical Tests for Engineering Undergraduates

2017 ◽  
Author(s):  
Michael G. Mauk ◽  
Richard Y. Chiou ◽  
Carlos Ruiz ◽  
Dharma Varapula ◽  
Changchun Liu ◽  
...  
Keyword(s):  
Undergraduate Students ◽  
Systems Engineering ◽  
Engineering Students ◽  
Undergraduate Research ◽  
Point Of Care ◽  
Lab On A Chip ◽  
Medical Diagnostics ◽  
Green Technology ◽  
Project Based Learning ◽  
Microfluidic Chips

Point-of-care (POC) medical diagnostics tests based on instrumented microfluidic chips are instructive and highly-multidisciplinary projects for undergraduate research and Senior Design. Students can apply their knowledge of fluid mechanics, heat transfer, optics, electronics and microcontrollers, materials, prototyping and systems engineering in translating and adapting a laboratory-based test for use in non-traditional venues. We discuss the design, prototyping, and testing of POC lab-on-a-chip (LOC) systems in an educational setting, where undergraduate students develop and demonstrate novel and practical POC tests. This application area serves as an effective gateway to the medical diagnostics field for engineering students, with opportunities for providing sustainable, appropriate, and ‘green’ technology to the developing world where healthcare infrastructure is lacking.

The potential impact of new generation molecular point-of-care tests on gonorrhoea and chlamydia in a setting of high endemic prevalence

Sexual Health ◽  
2013 ◽  
Vol 10 (4) ◽  
pp. 348 ◽  
Author(s):  
Ben B. Hui ◽  
David P. Wilson ◽  
James S. Ward ◽  
Rebecca J. Guy ◽  
John M. Kaldor ◽  
...  
Keyword(s):  
Point Of Care ◽  
Treatment Strategies ◽  
High Sensitivity ◽  
Indigenous Communities ◽  
Great Promise ◽  
Screening Methods ◽  
Sexually Transmissible Infections ◽  
Screening Coverage ◽  
New Generation ◽  
The Impact

Background Despite the availability of testing and treatment, bacterial sexually transmissible infections (STIs) continue to occur at endemic levels in many remote Indigenous communities in Australia. New generation molecular point-of-care (POC) tests have high sensitivity, comparable with conventional diagnostic tests, and have the potential to increase the impact of STI screening. Methods: We developed mathematical models of gonorrhoea (Neisseria gonorrhoeae) and chlamydia (Chlamydia trachomatis) transmission in remote Indigenous communities in Australia to evaluate screening and treatment strategies that utilise POC tests. Results: The introduction of POC testing with 95% sensitivity could reduce the prevalence of gonorrhoea and chlamydia from 7.1% and 11.9% to 5.7% and 8.9%, respectively, under baseline screening coverage of 44% per year. If screening coverage is increased to 60% per year, prevalence is predicted to be reduced to 3.6% and 6.7%, respectively, under conventional testing, and further reduced to 1.8% and 3.1% with the introduction of POC testing. Increasing screening coverage to 80% per year will result in a reduction in the prevalence of gonorrhoea and chlamydia to 0.6% and 1.5%, respectively, and the virtual elimination of both STIs if POC testing is introduced. Conclusions: Modelling suggests that molecular POC tests of high sensitivity have great promise as a public health strategy for controlling chlamydia and gonorrhoea. However, evaluation of the cost-effectiveness of POC testing needs to be made before widespread implementation of this technology can be considered.

Polymethyl methacrylate (PMMA) point of care for ABO-Rh(D) blood typing

2018 ◽  
Vol 273 ◽  
pp. 703-709 ◽  
Author(s):  
Chinnawut Pipatpanukul ◽  
Chanwit Kataphiniharn ◽  
Thidarat Wangkam ◽  
Boonsong Sutapun ◽  
Pimpun Kitpoka ◽  
...  
Keyword(s):  
Polymethyl Methacrylate ◽  
Point Of Care ◽  
Blood Typing

Development of a magnetic lab-on-a-chip for point-of-care sepsis diagnosis

2009 ◽  
Vol 321 (10) ◽  
pp. 1671-1675 ◽  
Author(s):  
Joerg Schotter ◽  
Astrit Shoshi ◽  
Hubert Brueckl
Keyword(s):  
Point Of Care ◽  
Lab On A Chip ◽  
Sepsis Diagnosis

scholarly journals Recent advances in nanoplasmonic biosensors: applications and lab-on-a-chip integration

Nanophotonics ◽  
2017 ◽  
Vol 6 (1) ◽  
pp. 123-136 ◽  
Author(s):  
Gerardo A. Lopez ◽  
M.-Carmen Estevez ◽  
Maria Soler ◽  
Laura M. Lechuga
Keyword(s):  
Point Of Care ◽  
Lab On A Chip ◽  
Cost Effective ◽  
Optical Biosensor ◽  
Point Of View ◽  
Localized Surface Plasmon ◽  
Interesting Candidate ◽  
Potential Benefits ◽  
Increasing Demand ◽  
Development And Validation

AbstractMotivated by the recent progress in the nanofabrication field and the increasing demand for cost-effective, portable, and easy-to-use point-of-care platforms, localized surface plasmon resonance (LSPR) biosensors have been subjected to a great scientific interest in the last few years. The progress observed in the research of this nanoplasmonic technology is remarkable not only from a nanostructure fabrication point of view but also in the complete development and integration of operative devices and their application. The potential benefits that LSPR biosensors can offer, such as sensor miniaturization, multiplexing opportunities, and enhanced performances, have quickly positioned them as an interesting candidate in the design of lab-on-a-chip (LOC) optical biosensor platforms. This review covers specifically the most significant achievements that occurred in recent years towards the integration of this technology in compact devices, with views of obtaining LOC devices. We also discuss the most relevant examples of the use of the nanoplasmonic biosensors for real bioanalytical and clinical applications from assay development and validation to the identification of the implications, requirements, and challenges to be surpassed to achieve fully operative devices.

scholarly journals Shaping acoustic fields as a toolset for microfluidic manipulations in diagnostic technologies

2012 ◽  
Vol 109 (38) ◽  
pp. 15162-15167 ◽  
Author(s):  
Julien Reboud ◽  
Yannyk Bourquin ◽  
Rab Wilson ◽  
Gurman S. Pall ◽  
Meesbah Jiwaji ◽  
...  
Keyword(s):  
Point Of Care ◽  
Pcr Amplification ◽  
Lab On A Chip ◽  
Dependent Manner ◽  
Acoustic Fields ◽  
Ultrasonic Fields ◽  
Analytical Functions ◽  
Order Of Magnitude ◽  
Diagnostic Technologies ◽  
Fluid Manipulation

Ultrasonics offers the possibility of developing sophisticated fluid manipulation tools in lab-on-a-chip technologies. Here we demonstrate the ability to shape ultrasonic fields by using phononic lattices, patterned on a disposable chip, to carry out the complex sequence of fluidic manipulations required to detect the rodent malaria parasite Plasmodium berghei in blood. To illustrate the different tools that are available to us, we used acoustic fields to produce the required rotational vortices that mechanically lyse both the red blood cells and the parasitic cells present in a drop of blood. This procedure was followed by the amplification of parasitic genomic sequences using different acoustic fields and frequencies to heat the sample and perform a real-time PCR amplification. The system does not require the use of lytic reagents nor enrichment steps, making it suitable for further integration into lab-on-a-chip point-of-care devices. This acoustic sample preparation and PCR enables us to detect ca. 30 parasites in a microliter-sized blood sample, which is the same order of magnitude in sensitivity as lab-based PCR tests. Unlike other lab-on-a-chip methods, where the sample moves through channels, here we use our ability to shape the acoustic fields in a frequency-dependent manner to provide different analytical functions. The methods also provide a clear route toward the integration of PCR to detect pathogens in a single handheld system.

A polymer lab-on-a-chip for reverse transcription (RT)-PCR based point-of-care clinical diagnostics

Lab on a Chip ◽  
2008 ◽  
Vol 8 (12) ◽  
pp. 2121 ◽  
Author(s):  
Soo Hyun Lee ◽  
Sung-Woo Kim ◽  
Ji Yoon Kang ◽  
Chong H. Ahn
Keyword(s):  
Reverse Transcription ◽  
Point Of Care ◽  
Lab On A Chip ◽  
Clinical Diagnostics ◽  
Rt Pcr
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