scholarly journals Magnetic Janus particles synthesized using droplet micro-magnetofluidic techniques for protein detection

Lab on a Chip ◽  
2017 ◽  
Vol 17 (20) ◽  
pp. 3514-3525 ◽  
Author(s):  
V. B. Varma ◽  
R. G. Wu ◽  
Z. P. Wang ◽  
R. V. Ramanujan
Keyword(s):  
Protein Detection ◽  
Janus Particles ◽  
Microfluidic Platform ◽  
Droplet Merging

Magnetic droplets on a microfluidic platform can act as micro-robots, providing wireless, remote, and programmable control useful for droplet merging, mixing and synthesis of Janus structures.

scholarly journals 3D-printed microfluidics integrated with optical nanostructured porous aptasensors for protein detection

2021 ◽  
Vol 188 (3) ◽  
Author(s):  
Sofia Arshavsky-Graham ◽  
Anton Enders ◽  
Shanny Ackerman ◽  
Janina Bahnemann ◽  
Ester Segal
Keyword(s):  
Limit Of Detection ◽  
Protein Detection ◽  
Target Protein ◽  
Superior Performance ◽  
Generic Model ◽  
Label Free ◽  
Uv Curable ◽  
Microfluidic Platform ◽  
Label Free Detection ◽  
3D Printed

AbstractMicrofluidic integration of biosensors enables improved biosensing performance and sophisticated lab-on-a-chip platform design for numerous applications. While soft lithography and polydimethylsiloxane (PDMS)-based microfluidics are still considered the gold standard, 3D-printing has emerged as a promising fabrication alternative for microfluidic systems. Herein, a 3D-printed polyacrylate-based microfluidic platform is integrated for the first time with a label-free porous silicon (PSi)–based optical aptasensor via a facile bonding method. The latter utilizes a UV-curable adhesive as an intermediate layer, while preserving the delicate nanostructure of the porous regions within the microchannels. As a proof-of-concept, a generic model aptasensor for label-free detection of his-tagged proteins is constructed, characterized, and compared to non-microfluidic and PDMS-based microfluidic setups. Detection of the target protein is carried out by real-time monitoring reflectivity changes of the PSi, induced by the target binding to the immobilized aptamers within the porous nanostructure. The microfluidic integrated aptasensor has been successfully used for detection of a model target protein, in the range 0.25 to 18 μM, with a good selectivity and an improved limit of detection, when compared to a non-microfluidic biosensing platform (0.04 μM vs. 2.7 μM, respectively). Furthermore, a superior performance of the 3D-printed microfluidic aptasensor is obtained, compared to a conventional PDMS-based microfluidic platform with similar dimensions. Graphical abstract

scholarly journals A Microfluidic Platform to design Multimodal PEG - crosslinked Hyaluronic Acid Nanoparticles (PEG-cHANPs) for diagnostic applications

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Olimpia Tammaro ◽  
Angela Costagliola di Polidoro ◽  
Eugenia Romano ◽  
Paolo Antonio Netti ◽  
Enza Torino
Keyword(s):  
Hyaluronic Acid ◽  
Microfluidic Platform ◽  
Diagnostic Applications

scholarly journals Microfluidic Platform for Analyzing the Thermotaxis of C. elegans in a Linear Temperature Gradient

2017 ◽  
Vol 33 (12) ◽  
pp. 1435-1440 ◽  
Author(s):  
Sunhee YOON ◽  
Hailing PIAO ◽  
Tae-Joon JEON ◽  
Sun Min KIM
Keyword(s):  
Temperature Gradient ◽  
Linear Temperature ◽  
Microfluidic Platform ◽  
C Elegans ◽  
Linear Temperature Gradient

scholarly journals Droplet Merging on a Lab-on-a-Chip Platform by Uniform Magnetic Fields

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
V. B. Varma ◽  
A. Ray ◽  
Z. M. Wang ◽  
Z. P. Wang ◽  
R. V. Ramanujan
Keyword(s):  
Magnetic Fields ◽  
Lab On A Chip ◽  
Droplet Merging

scholarly journals Active Janus particles in a complex plasma

2020 ◽  
Vol 2 (3) ◽  
Author(s):  
V. Nosenko ◽  
F. Luoni ◽  
A. Kaouk ◽  
M. Rubin-Zuzic ◽  
H. Thomas
Keyword(s):  
Janus Particles ◽  
Complex Plasma

scholarly journals Thermophoresis of Janus particles at large Knudsen numbers

2018 ◽  
Vol 3 (9) ◽  
Author(s):  
Tobias Baier ◽  
Sudarshan Tiwari ◽  
Samir Shrestha ◽  
Axel Klar ◽  
Steffen Hardt
Keyword(s):  
Janus Particles ◽  
Knudsen Numbers
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