scholarly journals Catalytic hydrogenation of N-4-nitrophenyl nicotinamide in a micro-packed bed reactor

2018 ◽  
Vol 20 (4) ◽  
pp. 886-893 ◽  
Author(s):  
Cuixian Yang ◽  
Andrew R. Teixeira ◽  
Yanxiang Shi ◽  
Stephen C. Born ◽  
Hongkun Lin ◽  
...  
Keyword(s):  
Catalytic Hydrogenation ◽  
Flow Chemistry ◽  
Packed Bed ◽  
Packed Bed Reactor ◽  
Micro Flow ◽  
Pharmaceutical Production

Recent advancements in micro-flow technologies and a drive toward more efficient, greener and safer processes have led to a renaissance in flow-chemistry for pharmaceutical production.

scholarly journals Ozone-Mediated Amine Oxidation and Beyond: A Solvent Free, Flow-Chemistry Approach

2021 ◽  
Author(s):  
Eric Skrotzki ◽  
Jaya Kishore Vandavasi ◽  
Stephen Newman
Keyword(s):  
Organic Molecules ◽  
Flow Chemistry ◽  
Packed Bed ◽  
High Reactivity ◽  
Solvent Free ◽  
Packed Bed Reactor ◽  
Primary Amines ◽  
Amine Oxidation ◽  
Synthetic Utility ◽  
Free Oxidation

Ozone is a powerful oxidant, most commonly used for oxidation of alkenes to carbonyls. The synthetic utility of other ozone-mediated reactions is hindered by its high reactivity and propensity to over-oxidize organic molecules, including most solvents. This challenge can largely be mitigated by adsorbing both substrate and ozone onto silica gel, providing a solvent-free oxidation method. In this manuscript, a flow-based packed bed reactor approach is described that provides exceptional control of reaction temperature and time of this reaction to achieve improved control and chemoselectivity over this challenging reaction. A powerful method to oxidize primary amines into nitroalkanes is achieved. Examples of pyridine, C–H bond, and arene oxidations are also demonstrated, confirming the system is generalizable to diverse ozone-mediated processes.<br>

Process Intensification of Quasi-Homogeneous Catalytic Hydrogenation in a Rotating Packed Bed Reactor

2019 ◽  
Vol 59 (3) ◽  
pp. 1383-1392 ◽  
Author(s):  
Di Wang ◽  
Ya-Zhao Liu ◽  
Bao-Ju Wang ◽  
Guang-Wen Chu ◽  
Bao-Chang Sun ◽  
...  
Keyword(s):  
Catalytic Hydrogenation ◽  
Process Intensification ◽  
Packed Bed ◽  
Packed Bed Reactor ◽  
Rotating Packed Bed

scholarly journals Improving Productivity of Multiphase Flow Aerobic Oxidation Using a Tube-in-Tube Membrane Contactor

Catalysts ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 95 ◽  
Author(s):  
Michael Burkholder ◽  
Stanley Gilliland ◽  
Adam Luxon ◽  
Christina Tang ◽  
B. Gupton
Keyword(s):  
Flow Reactor ◽  
Aerobic Oxidation ◽  
Flow Chemistry ◽  
Packed Bed ◽  
Space Time ◽  
Catalytic Reactions ◽  
Packed Bed Reactor ◽  
Membrane Contactor ◽  
Flow Reactors ◽  
Space Time Yield

The application of flow reactors in multiphase catalytic reactions represents a promising approach for enhancing the efficiency of this important class of chemical reactions. We developed a simple approach to improve the reactor productivity of multiphase catalytic reactions performed using a flow chemistry unit with a packed bed reactor. Specifically, a tube-in-tube membrane contactor (sparger) integrated in-line with the flow reactor has been successfully applied to the aerobic oxidation of benzyl alcohol to benzaldehyde utilizing a heterogeneous palladium catalyst in the packed bed. We examined the effect of sparger hydrodynamics on reactor productivity quantified by space time yield (STY). Implementation of the sparger, versus segmented flow achieved with the built in gas dosing module (1) increased reactor productivity 4-fold quantified by space time yield while maintaining high selectivity and (2) improved process safety as demonstrated by lower effective operating pressures.

scholarly journals Ozone-Mediated Amine Oxidation and Beyond: A Solvent Free, Flow-Chemistry Approach

2021 ◽  
Author(s):  
Eric Skrotzki ◽  
Jaya Kishore Vandavasi ◽  
Stephen Newman
Keyword(s):  
Organic Molecules ◽  
Flow Chemistry ◽  
Packed Bed ◽  
High Reactivity ◽  
Solvent Free ◽  
Packed Bed Reactor ◽  
Primary Amines ◽  
Amine Oxidation ◽  
Synthetic Utility ◽  
Free Oxidation

Ozone is a powerful oxidant, most commonly used for oxidation of alkenes to carbonyls. The synthetic utility of other ozone-mediated reactions is hindered by its high reactivity and propensity to over-oxidize organic molecules, including most solvents. This challenge can largely be mitigated by adsorbing both substrate and ozone onto silica gel, providing a solvent-free oxidation method. In this manuscript, a flow-based packed bed reactor approach is described that provides exceptional control of reaction temperature and time of this reaction to achieve improved control and chemoselectivity over this challenging reaction. A powerful method to oxidize primary amines into nitroalkanes is achieved. Examples of pyridine, C–H bond, and arene oxidations are also demonstrated, confirming the system is generalizable to diverse ozone-mediated processes.<br>

Continuous production of a chiral amine in a packed bed reactor with co-immobilized amine dehydrogenase and formate dehydrogenase

2021 ◽  
Vol 407 ◽  
pp. 127065
Author(s):  
Robert D. Franklin ◽  
Joshua A. Whitley ◽  
Adam A. Caparco ◽  
Bettina R. Bommarius ◽  
Julie A. Champion ◽  
...  
Keyword(s):  
Formate Dehydrogenase ◽  
Continuous Production ◽  
Packed Bed ◽  
Packed Bed Reactor ◽  
Chiral Amine ◽  
Amine Dehydrogenase
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