Base-controlled highly selective synthesis of alkyl 1,2-bis(boronates) or 1,1,2-tris(boronates) from terminal alkynes

2017 ◽  
Vol 19 (17) ◽  
pp. 3997-4001 ◽  
Author(s):  
Guoliang Gao ◽  
Jianxiang Yan ◽  
Kai Yang ◽  
Fener Chen ◽  
Qiuling Song
Keyword(s):  
Transition Metal ◽  
Regioselective Synthesis ◽  
Selective Synthesis ◽  
Terminal Alkynes ◽  
Free Base ◽  
Metal Free

Transition-metal-free base-controlled highly regioselective synthesis of alkyl 1,2-bis(boronates) or 1,1,2-tris(boronates) from various terminal alkynes has been disclosed.

A Sequential Ugi-Smiles / Transition-Metal-Free Endo-Dig Conia-ene Cyclization: The Selective Synthesis of Saccharin Substituted 2,5-dihydropyrroles

2021 ◽  
Author(s):  
Hassan Seyrani ◽  
Sorour Ramezanpour ◽  
Aref Vaezghaemi ◽  
Farzad Kobarfard
Keyword(s):  
Transition Metal ◽  
Free Access ◽  
Selective Synthesis ◽  
Metal Free ◽  
Mild Conditions

A convenient, transition-metal-free access to a series of unprecedented saccharin substituted 2,5-dihydropyrroles is reported. This approach employs a post-Ugi-Smiles 5-endo-dig Conia-ene cyclization sequence in mild conditions while incorporating a series...

Facile Access to Triazole-Fused 3,1-Benzoxazines Enabled by Metal-Free Base-Promoted Intramolecular C–O Coupling

Synthesis ◽  
2021 ◽  
Author(s):  
Yury N. Kotovshchikov ◽  
Stepan S. Tatevosyan ◽  
Gennadij V. Latyshev ◽  
Nikolay V. Lukashev ◽  
Irina P. Beletskaya
Keyword(s):  
Transition Metal ◽  
Functional Group ◽  
Cost Effective ◽  
Reductive Cleavage ◽  
Effective Procedure ◽  
Free Base ◽  
Metal Free ◽  
Fused Heterocycles ◽  
Convenient Approach

AbstractA convenient approach to assemble 1,2,3-triazole-fused 4H-3,1-benzoxazines has been developed. Diverse alcohol-tethered 5-iodotriazoles, readily accessible by a modified protocol of Cu-catalyzed (3+2)-cycloaddition, were utilized as precursors of the target fused heterocycles. The intramolecular C–O coupling proceeded efficiently under base-mediated transition-metal-free conditions, furnishing cyclization products in yields up to 96%. Suppression of the competing reductive cleavage of the C–I bond was achieved by the use of Na2CO3 in acetonitrile at 100 °C. This practical and cost-effective procedure features a broad substrate scope and valuable functional group tolerance.

Sodium persulfate-promoted site-selective synthesis of mononitroarylamines under transition-metal-free conditions

Tetrahedron ◽  
2019 ◽  
Vol 75 (9) ◽  
pp. 1157-1165
Author(s):  
De-Xun Xie ◽  
Hui-Juan Yu ◽  
Hui Liu ◽  
Wei-Cai Xue ◽  
Yuan-Shou Qin ◽  
...  
Keyword(s):  
Transition Metal ◽  
Selective Synthesis ◽  
Sodium Persulfate ◽  
Metal Free ◽  
Site Selective

Transition metal-free base-promoted arylation of sulfenate anions with diaryliodonium salts

2019 ◽  
Vol 6 (1) ◽  
pp. 32-35 ◽  
Author(s):  
Lei Wang ◽  
Mingjie Chen ◽  
Junliang Zhang
Keyword(s):  
Transition Metal ◽  
Free Base ◽  
Metal Free ◽  
Diaryliodonium Salts

A base-promoted formal arylation of general sulfenate anions with diaryliodonium salts under transition-metal-free conditions has been described.

Transition Metal‐Free, Base‐Induced Arylation of Amino Acids: Synthesis of N ‐( para ‐Substituted phenyl)amino‐2‐carboxylic acids

2020 ◽  
Vol 5 (28) ◽  
pp. 8644-8648 ◽  
Author(s):  
Adejoke D. Osinubi ◽  
Josephat U. Izunobi ◽  
Olayinka T. Asekun ◽  
Oluwole B. Familoni ◽  
Xiaoguang Bao
Keyword(s):  
Amino Acids ◽  
Transition Metal ◽  
Carboxylic Acids ◽  
Free Base ◽  
Metal Free

Transition-Metal-Free Atropo-Selective Synthesis of Biaryl Compounds Based on Arynes

2012 ◽  
Vol 18 (45) ◽  
pp. 14232-14236 ◽  
Author(s):  
Frédéric R. Leroux ◽  
Anaïs Berthelot ◽  
Laurence Bonnafoux ◽  
Armen Panossian ◽  
Françoise Colobert
Keyword(s):  
Transition Metal ◽  
Selective Synthesis ◽  
Metal Free ◽  
Biaryl Compounds

One-pot transition-metal-free cascade synthesis of thieno[2,3-c]coumarins from chromones

RSC Advances ◽  
2016 ◽  
Vol 6 (106) ◽  
pp. 103895-103898 ◽  
Author(s):  
Yuhong Yang ◽  
Xueyu Qi ◽  
Ruiling Liu ◽  
Qian He ◽  
Chunhao Yang
Keyword(s):  
Transition Metal ◽  
Cascade Reaction ◽  
Free Base ◽  
One Pot ◽  
Metal Free

A one-pot transition-metal-free, base-mediated synthesis of a novel series of functionalized thieno[2,3-c]coumarins has been developed through a cascade reaction from chromones.

ChemInform Abstract: Regioselective Synthesis of Phenoxathiin Derivatives under Transition-Metal-Free Conditions.

ChemInform ◽  
2013 ◽  
Vol 44 (30) ◽  
pp. no-no
Author(s):  
Fangdong Hu ◽  
Xin Zhao ◽  
Yanqiu Li ◽  
Lei Feng ◽  
Chen Ma
Keyword(s):  
Transition Metal ◽  
Regioselective Synthesis ◽  
Metal Free

Transition-metal-free sp3 C–H activation of 2-methylquinoline with terminal alkynes for synthesis of 3-(quinolin-2-yl)isoxazoles

2019 ◽  
Vol 60 (21) ◽  
pp. 1443-1447 ◽  
Author(s):  
Lei Meng ◽  
Shuwei Zhang ◽  
Xiaodong Jia ◽  
Liangzhong Lv ◽  
Yu Yuan
Keyword(s):  
Transition Metal ◽  
Terminal Alkynes ◽  
Metal Free
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