Black tea increases hypertonic stress resistance in C. elegans

2018 ◽  
Vol 9 (7) ◽  
pp. 3798-3806 ◽  
Author(s):  
Pei Yuan ◽  
Lian-yun Pan ◽  
Li-gui Xiong ◽  
Jie-wen Tong ◽  
Juan Li ◽  
...  

Black tea extract is more effective than green tea extract in protecting C. elegans against hypertonic stress, within the studied concentration range.

2010 ◽  
Vol 30 (8) ◽  
pp. 884-896 ◽  
Author(s):  
Amar K Chandra ◽  
Neela De ◽  
Shyamosree Roy Choudhury

Tea is a rich source of polyphenolic flavonoids including catechins, which are thought to contribute to the health benefits of it. Flavonoids have been reported to have antithyroid and goitrogenic effect. The purpose of this study was to evaluate whether high doses of green and black tea have a harmful effect on thyroid physiology. Un-fractionated green and black tea extracts were administered orally to male rats for 30 days at doses of 1.25 g%, 2.5 g% and 5.0 g%. The results showed that green tea extract at 2.5 g% and 5.0 g% doses and black tea extract only at 5.0 g% dose have the potential to alter the thyroid gland physiology and architecture, that is, enlargement of thyroid gland as well as hypertrophy and/or hyperplasia of the thyroid follicles and inhibition of the activity of thyroid peroxidase and 5′-deiodinase I with elevated thyroidal Na+, K+-ATPase activity along with significant decrease in serum T3 and T4, and a parallel increase in serum thyroid stimulating hormone (TSH). This study concludes that goitrogenic/antithyroidal potential of un-fractionated green tea extract is much more than black tea extract because of the differences in catechin contents in the tea extracts.


2010 ◽  
Vol 58 (2) ◽  
pp. 1350-1358 ◽  
Author(s):  
Di Wang ◽  
Rong Xiao ◽  
Xueting Hu ◽  
Kunlong Xu ◽  
Yan Hou ◽  
...  

Author(s):  
Andi Arjuna ◽  
Winda Setya Pratama ◽  
Sartini Sartini ◽  
Mufidah Mufidah

Tea (Camellia sinensis L.) has an activity as an antibacterial, widely studied to plankton cells, without further researching into biofilm cell. Therefore, this research had been conducted to initially evaluate the activity of green- and black-tea extracts in inhibiting Streptococcus mutans biofilm. Green and black tea leaves were extracted using 70% methanol. Determination of MIC was subsequently performed by microdilution method. Next, the biofilm formation and inhibition were run through microtiter plate method using flexible U-bottom PVC 96 wells, which then observed using microplate reader on λ = 515 nm. As The results, MIC for green and black tea extract stood at 4 mg/mL, 6 mg/mL respectively. The biofilm inhibitory activity of black tea extract was at 8 and 10 mg/mL inhibiting 6 % and 12.5 % S. mutans. Green tea extract showed that concentration of 4 to 10 mg/mL was able to inhibit biofilm growth by 24%; 45%; 48% and 53%. Thus, through microtiter plate assay, it could be concluded that tea extract has potent antibiofilm to S. mutans, where green tea extract has better activity than black tea extract.


2004 ◽  
Vol 80 (6) ◽  
pp. 1558-1564 ◽  
Author(s):  
Susanne M Henning ◽  
Yantao Niu ◽  
Nicolas H Lee ◽  
Gail D Thames ◽  
Rosario R Minutti ◽  
...  

2017 ◽  
pp. 137-152
Author(s):  
K. A. Treasa Nimy ◽  
Vincent Terrence Rebello ◽  
T. K. Mukundan

2021 ◽  
Author(s):  
Stephen A Banse ◽  
Christine A Sedore ◽  
Erik Johnson ◽  
Anna L Coleman-Hulbert ◽  
Brian Onken ◽  
...  

The Caenorhabditis Intervention Testing Program (CITP) is an NIH–funded research consortium of investigators who conduct analyses at three independent sites to identify chemical interventions that reproducibly promote health and lifespan in a robust manner. The founding principle of the CITP is that compounds with positive effects across a genetically diverse panel of Caenorhabditis species and strains are likely engaging conserved biochemical pathways to exert their effects. As such, interventions that are broadly efficacious might be considered prominent compounds for translation for pre-clinical research and human clinical applications. Here, we report results generated using a recently streamlined pipeline approach for the evaluation of the effects of chemical compounds on lifespan and health. We studied five compounds previously shown to extend C. elegans lifespan or thought to promote mammalian health: 17α–estradiol, acarbose, green tea extract, nordihydroguaiaretic acid, and rapamycin. We found that green tea extract and nordihydroguaiaretic acid extend Caenorhabditis lifespan in a species-specific manner. Additionally, these two antioxidants conferred assay-specific effects in some studies–for example, decreasing survival for certain genetic backgrounds in manual survival assays in contrast with extended lifespan as assayed using automated C. elegans Lifespan Machines. We also observed that GTE and NDGA impact on older adult mobility capacity is dependent on genetic background, and that GTE reduces oxidative stress resistance in some Caenorhabditis strains. Overall, our analysis of the five compounds supports the general idea that genetic background and assay type can influence lifespan and health effects of compounds, and underscores that lifespan and health can be uncoupled by chemical interventions.


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