Different antitumor effects of quercetin, quercetin-3′-sulfate and quercetin-3-glucuronide in human breast cancer MCF-7 cells

2018 ◽  
Vol 9 (3) ◽  
pp. 1736-1746 ◽  
Author(s):  
Qiu Wu ◽  
Paul W. Needs ◽  
Yalong Lu ◽  
Paul A. Kroon ◽  
Daoyuan Ren ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Mechanism ◽  
Human Breast Cancer ◽  
Water Soluble ◽  
Human Breast ◽  
Inhibitory Effects ◽  
Antitumor Effects ◽  
Mcf 7

This study was designed to investigate the tumor-inhibitory effects of quercetin (Que) and its water-soluble metabolites, quercetin-3′-sulfate (Q3′S) and quercetin-3-glucuronide (Q3G), as well as to make the molecular mechanism and structure-antitumor relationship clear.

Antitumor effects of seleno-β-lactoglobulin on human breast cancer MCF-7 and MDA-MB-231 cells in vitro

2019 ◽  
Vol 61 ◽  
pp. 104607 ◽  
Author(s):  
Xiaomeng Xu ◽  
Yingying Feng ◽  
Xiaoyu Chen ◽  
Qinjian Wang ◽  
Ting Meng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Antitumor Effects ◽  
Β Lactoglobulin ◽  
Mcf 7

Growth-inhibitory effects of the natural phyto-oestrogen genistein in MCF-7 human breast cancer cells

1994 ◽  
Vol 30 (11) ◽  
pp. 1675-1682 ◽  
Author(s):  
M.C. Pagliacci ◽  
M. Smacchia ◽  
G. Migliorati ◽  
F. Grignani ◽  
C. Riccardi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Inhibitory Effects ◽  
Growth Inhibitory ◽  
Mcf 7

scholarly journals Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Hongzhuan Xuan ◽  
Zhen Li ◽  
Haiyue Yan ◽  
Qing Sang ◽  
Kai Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Membrane Potential ◽  
Mitochondrial Membrane Potential ◽  
Human Breast Cancer ◽  
Mitochondrial Membrane ◽  
Biological Activities ◽  
Human Breast ◽  
Antitumor Effects ◽  
Chinese Propolis ◽  
Mcf 7

Chinese propolis has been reported to possess various biological activities such as antitumor. In present study, anticancer activity of ethanol extract of Chinese propolis (EECP) at 25, 50, 100, and 200 μg/mL was explored by testing the cytotoxicity in MCF-7 (human breast cancer ER(+)) and MDA-MB-231 (human breast cancer ER(−)) cells. EECP revealed a dose- and time-dependent cytotoxic effect. Furthermore, annexin A7 (ANXA7), p53, nuclear factor-κB p65 (NF-κB p65), reactive oxygen species (ROS) levels, and mitochondrial membrane potential were investigated. Our data indicated that treatment of EECP for 24 and 48 h induced both cells apoptosis obviously. Exposure to EECP significantly increased ANXA7 expression and ROS level, and NF-κB p65 level and mitochondrial membrane potential were depressed by EECP dramatically. The effects of EECP on p53 level were different in MCF-7 and MDA-MB-231 cells, which indicated that EECP exerted its antitumor effects in MCF-7 and MDA-MB-231 cells by inducing apoptosis, regulating the levels of ANXA7, p53, and NF-κB p65, upregulating intracellular ROS, and decreasing mitochondrial membrane potential. Interestingly, EECP had little or small cytotoxicity on normal human umbilical vein endothelial cells (HUVECs). These results suggest that EECP is a potential alternative agent on breast cancer treatment.

Long-term inhibitory effects of a novel anti-estrogen on the growth of ZR-75-1 and MCF-7 human breast cancer tumors in nude mice

1997 ◽  
Vol 73 (5) ◽  
pp. 735-739 ◽  
Author(s):  
Shouqi Luo ◽  
Céline Martel ◽  
Sylvain Gauthier ◽  
Yves Mérand ◽  
Alain Bélanger ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nude Mice ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Inhibitory Effects ◽  
Mcf 7
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