Prophylactic role of vitamin K supplementation on vascular inflammation in type 2 diabetes by regulating the NF-κB/Nrf2 pathwayviaactivating Gla proteins

2018 ◽  
Vol 9 (1) ◽  
pp. 450-462 ◽  
Author(s):  
Anjum Dihingia ◽  
Dibyajyoti Ozah ◽  
Pranab Kumar Baruah ◽  
Jatin Kalita ◽  
Prasenjit Manna
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin K ◽  
Vascular Inflammation ◽  
Vitamin K1 ◽  
The Relationship

There is no previous study that has examined the relationship between circulating vitamin K1 (VK1) and vascular inflammation in type 2 diabetes (T2D).

scholarly journals Microbiota, type 2 diabetes and non-alcoholic fatty liver disease: protocol of an observational study

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Benedetta M. Motta ◽  
Christoph Grander ◽  
Martin Gögele ◽  
Luisa Foco ◽  
Vladimir Vukovic ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Liver Disease ◽  
Fatty Liver Disease ◽  
Liver Stiffness ◽  
Alcoholic Fatty Liver ◽  
Study Participants ◽  
The Relationship ◽  
Alcoholic Fatty Liver Disease

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is characterized by triglyceride accumulation in the hepatocytes in the absence of alcohol overconsumption, commonly associated with insulin resistance and obesity. Both NAFLD and type 2 diabetes (T2D) are characterized by an altered microbiota composition, however the role of the microbiota in NAFLD and T2D is not well understood. To assess the relationship between alteration in the microbiota and NAFLD while dissecting the role of T2D, we established a nested study on T2D and non-T2D individuals within the Cooperative Health Research In South Tyrol (CHRIS) study, called the CHRIS-NAFLD study. Here, we present the study protocol along with baseline and follow-up characteristics of study participants. Methods Among the first 4979 CHRIS study participants, 227 individuals with T2D were identified and recalled, along with 227 age- and sex-matched non-T2D individuals. Participants underwent ultrasound and transient elastography examination to evaluate the presence of hepatic steatosis and liver stiffness. Additionally, sampling of saliva and faeces, biochemical measurements and clinical interviews were carried out. Results We recruited 173 T2D and 183 non-T2D participants (78% overall response rate). Hepatic steatosis was more common in T2D (63.7%) than non-T2D (36.3%) participants. T2D participants also had higher levels of liver stiffness (median 4.8 kPa, interquartile range (IQR) 3.7, 5.9) than non-T2D participants (median 3.9 kPa, IQR 3.3, 5.1). The non-invasive scoring systems like the NAFLD fibrosis score (NFS) suggests an increased liver fibrosis in T2D (mean − 0.55, standard deviation, SD, 1.30) than non-T2D participants (mean − 1.30, SD, 1.17). Discussion Given the comprehensive biochemical and clinical characterization of study participants, once the bioinformatics classification of the microbiota will be completed, the CHRIS-NAFLD study will become a useful resource to further our understanding of the relationship between microbiota, T2D and NAFLD.

scholarly journals Relationship Between Social Capital and Depressive Symptoms Among Type 2 Diabetes Mellitus Patients in Northwest China: A Mediating Role of Sleep Quality

2021 ◽  
Vol 12 ◽  
Author(s):  
Liqun Wang ◽  
Jiangping Li ◽  
Yuqi Dang ◽  
Haiyu Ma ◽  
Yang Niu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Depressive Symptoms ◽  
Sleep Quality ◽  
Northwest China ◽  
Mediating Role ◽  
The Relationship

Objective: There are few studies about the relationship between social capital (SC) and depression among type 2 diabetes mellitus (T2DM) patients, and the mechanism explaining how SC leads to decreased depression is unclear. The current study aims to explore the relationship between SC and depressive symptoms among the T2DM patients in northwest China, with a particular focus on the mediating role of sleep quality.Methods: A cross-sectional study of 1,761 T2DM patients from Ningxia Province was conducted. The Center for Epidemiological Survey Depression Scale (CES-D) and self-report sleep quality questionnaire coupled with the SC scales were administered during the face-to-face survey. The Bootstrap methods PROCESS program is employed to test the mediation model.Results: The prevalence of depressive symptoms among T2DM patients was 24.8%. After controlling for covariates, the SC (r = −0.23, p < 0.001) was negatively correlated with CES-D score; the sleep quality was also negatively correlated with CES-D score (r = −0.31, p < 0.001); and the SC was positively correlated with sleep quality (r = 0.10, p < 0.001). Logistic regression analysis showed that SC was inversely related to the risk of depressive symptoms. Meanwhile, sleep quality was negatively associated with depressive symptoms. Sleep quality has mediated the relationship between SC and depressive symptoms among T2DM patients (explaining 12.6% of the total variance).Conclusions: We elucidated how SC interacted with depressive symptoms through the mediation pathway of sleep quality using a representative sample of the Chinese diabetes patients. The findings indicate that the improvement of SC and sleep quality may help in maintaining mental health among T2DM patients. Hence, clinicians can suggest that patients communicate more with others to improve the SC and, in turn, maintain their health.

The role of social support on the relationship of depressive symptoms to medication adherence and self-care activities in adults with type 2 diabetes

2015 ◽  
Vol 71 (9) ◽  
pp. 2164-2175 ◽  
Author(s):  
Chun-Ja Kim ◽  
Elizabeth A. Schlenk ◽  
Dae Jung Kim ◽  
Moonsun Kim ◽  
Judith A. Erlen ◽  
...  
Keyword(s):  
Social Support ◽  
Type 2 Diabetes ◽  
Depressive Symptoms ◽  
Medication Adherence ◽  
Self Care ◽  
Relationship Of ◽  
The Relationship

scholarly journals Obesity in the Pathogenesis of type 2 Diabetes

KYAMC Journal ◽  
2017 ◽  
Vol 4 (1) ◽  
pp. 357-361 ◽  
Author(s):  
Farzana Mahmuda ◽  
Marufa Akhter ◽  
Ronjon Kumer Nath
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight Regulation ◽  
Physiological Conditions ◽  
Quantitative Genetic ◽  
Sedentary Life ◽  
Sedentary Life Style ◽  
The Relationship ◽  
Diabetes And Obesity

The article reviews the relationship between type 2 diabetes and obesity. This also includes types of obesity and it's genetic predisposition. The modern generalization of sedentary life style and caloric abundance has created new physiological conditions capable of changing the level of expression of a number of genes involved in fuel metabolism and body weight regulation. In this article, we underscore the importance of obesity in relation to disorders of diverse etiologies characterized by disturbances of free fatty acids, visceral adiposity and insulin resistance. Further, we have investigated the role of selecting the traits to be subjected to quantitative genetic analysis in the occurrence of obesity.KYAMC Journal Vol. 4, No.-1, July 2013, Page 357-361

Gamma‐glutamyl–carboxylated Gas6 mediates positive role of vitamin K on lowering hyperglycemia in type 2 diabetes

2019 ◽  
Vol 1462 (1) ◽  
pp. 104-117 ◽  
Author(s):  
Anjum Dihingia ◽  
Dibyajyoti Ozah ◽  
Thaneswar Borah ◽  
Jatin Kalita ◽  
Prasenjit Manna
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin K ◽  
Positive Role ◽  
Gamma Glutamyl

scholarly journals Circulating Nesfatin-1 Levels and Type 2 Diabetes: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Ting Zhai ◽  
Shi-Zhen Li ◽  
Xin-Tong Fan ◽  
Zhao Tian ◽  
Xiao-Qing Lu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Meta Analysis ◽  
Control Group ◽  
Newly Diagnosed ◽  
Antidiabetic Treatment ◽  
The Relationship ◽  
Diabetes Patients

The role of nesfatin-1 in glucose homeostasis has been investigated previously. However, although numerous studies have examined the relationships between circulating nesfatin-1 levels and type 2 diabetes, the conclusions are contradictory. We aimed to probe the relationship between circulating nesfatin-1 levels and type 2 diabetes by meta-analysis. Seven studies including 328 type 2 diabetes patients and 294 control subjects were included. Although there was no obvious difference in circulating nesfatin-1 levels between patients with type 2 diabetes and the control group (MD = −0.04; 95% CI = −0.32 to −0.23), subgroup analysis showed higher nesfatin-1 levels in newly diagnosed type 2 diabetes patients (MD = 0.59; 95% CI = 0.45 to 0.74) and significantly lower nesfatin-1 levels in type 2 diabetes patients receiving antidiabetic treatment (MD = −0.26; 95% CI = −0.33 to −0.20). In conclusion, the analysis supports a relationship between circulating nesfatin-1 levels and type 2 diabetes, where newly diagnosed type 2 diabetes was associated with an elevated Nesfatin-1 level, and type 2 diabetes patients receiving antidiabetic treatment showed lower circulating nesfatin-1 levels.

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