Dietary supplementation with omega-3 polyunsaturated fatty acid-rich oils protects against visible-light-induced retinal damage in vivo

2018 ◽  
Vol 9 (4) ◽  
pp. 2469-2479 ◽  
Author(s):  
Qianchun Deng ◽  
Yong Wang ◽  
Chengtao Wang ◽  
Baoping Ji ◽  
Renhuai Cong ◽  
...  

Dietary ω-3 PUFA-rich oils protect against visible-light-induced retinal damage.

2017 ◽  
Vol 99 ◽  
pp. 79-89 ◽  
Author(s):  
Ajit Singh Mahla ◽  
Ravjibhai K. Chaudhari ◽  
Atul Kumar Verma ◽  
Amit Kumar Singh ◽  
Sanjay Kumar Singh ◽  
...  

10.5219/1534 ◽  
2021 ◽  
Vol 15 ◽  
pp. 521-527
Author(s):  
Azad Sabow ◽  
Nazim Abdulla ◽  
Bestoon Ahmad

The present study was aimed to evaluate the effect of dietary supplementation with Lactuca serriola leaves on growth performance, carcass characteristics, meat quality, and its antioxidant stability of Japanese quails. A total of eighty growing quails (1-week old) were distributed into 2 equal groups consisting of 40 birds (5 replicates of 8 birds each). The first group was fed a basal diet without Lactuca serriola leaves (0 g.kg-1 diet) and the second group received diets containing 20 g.kg-1 Lactuca serriola leaves. At age of 6 weeks, quails were slaughtered for meat and carcass examinations. The growth performance for the quails fed with Lactuca serriola leaves diet was similar to that of a control group. Carcass measurements, physical properties, and chemical composition of quail breast meat did not differ between the control and experimental group. However, the inclusion of Lactuca serriola leaves significantly increased the omega-3 polyunsaturated fatty acid content and improved breast meat lipid stability during postmortem refrigerated storage compared to the control diet. In conclusion, dietary supplementation of Lactuca serriola leaves can improve the performance of Japanese quail enrich its meat with an omega-3 polyunsaturated fatty acid, and reduce lipid oxidation during storage.


Blood ◽  
2011 ◽  
Vol 118 (26) ◽  
pp. 6909-6919 ◽  
Author(s):  
Shailaja Hegde ◽  
Naveen Kaushal ◽  
Kodihalli C. Ravindra ◽  
Christopher Chiaro ◽  
Kelsey T. Hafer ◽  
...  

Abstract Targeting cancer stem cells is of paramount importance in successfully preventing cancer relapse. Recently, in silico screening of public gene-expression datasets identified cyclooxygenase-derived cyclopentenone prostaglandins (CyPGs) as likely agents to target malignant stem cells. We show here that Δ12-PGJ3, a novel and naturally produced CyPG from the dietary fish-oil ω-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA; 20:5) alleviates the development of leukemia in 2 well-studied murine models of leukemia. IP administration of Δ12-PGJ3 to mice infected with Friend erythroleukemia virus or those expressing the chronic myelogenous leukemia oncoprotein BCR-ABL in the hematopoietic stem cell pool completely restored normal hematologic parameters, splenic histology, and enhanced survival. More importantly, Δ12-PGJ3 selectively targeted leukemia stem cells (LSCs) for apoptosis in the spleen and BM. This treatment completely eradicated LSCs in vivo, as demonstrated by the inability of donor cells from treated mice to cause leukemia in secondary transplantations. Given the potency of ω-3 polyunsaturated fatty acid–derived CyPGs and the well-known refractoriness of LSCs to currently used clinical agents, Δ12-PGJ3 may represent a new chemotherapeutic for leukemia that targets LSCs.


1989 ◽  
Vol 36 (4) ◽  
pp. 653-660 ◽  
Author(s):  
William F. Clark ◽  
Anwar Parbtani ◽  
Murray W. Huff ◽  
Bruce Reid ◽  
Bruce J. Holub ◽  
...  

2010 ◽  
Vol 20 (5) ◽  
pp. 321-328 ◽  
Author(s):  
Nassima Bouzidi ◽  
Khedidja Mekki ◽  
Ali Boukaddoum ◽  
Nawel Dida ◽  
Abbou Kaddous ◽  
...  

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