Procyanidins extracted from the litchi pericarp ameliorate atherosclerosis in ApoE knockout mice: their effects on nitric oxide bioavailability and oxidative stress

2017 ◽  
Vol 8 (11) ◽  
pp. 4210-4216 ◽  
Author(s):  
Shuang Rong ◽  
Xueting Hu ◽  
Siqi Zhao ◽  
Yanting Zhao ◽  
Xiao Xiao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Cardiovascular Diseases ◽  
Knockout Mice ◽  
Epidemiological Studies ◽  
Apoe Knockout Mice ◽  
And Oxidative Stress ◽  
Litchi Pericarp ◽  
Nitric Oxide Bioavailability

Epidemiological studies strongly support the role of procyanidin-rich beverages and fruit in the prevention of cardiovascular diseases.

scholarly journals Comparative Analysis of Luteolin and Luteolin-7-O-Glucoside on anti-Atherogenesis in ApoE Knockout Mice with Hyperhomocysteinemia

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Yeon-A. Son ◽  
Chung-Mu Park ◽  
Youngsun Song
Keyword(s):  
Oxidative Stress ◽  
Adhesion Molecules ◽  
Antioxidative Enzymes ◽  
Adhesion Molecule ◽  
Knockout Mice ◽  
Body Weight Gain ◽  
Intercellular Adhesion Molecule ◽  
Control Group ◽  
Apoe Knockout Mice ◽  
And Oxidative Stress

AbstractLuteolin is a naturally occurring flavone that reportedly has anti-inflammatory effect. Flavones in plants are usually present in the form of glucosides, although occasionally they are found as aglycones. The bioavailability of flavones may differ when consumed as either aglycones or glucosides. Nonetheless, numerous studies focused on the biological activity of flavonoid aglycones or that in vitro. These findings are supporting reason to compare the anti-atherogenic effect of aglycone and glucoside forms of flavones in vivo. Male ApoE knockout mice (n = 28, 6-week-old) were divided randomly into 4 groups of 7 mice: negative control group, homocysteine control group, luteolin and luteolin7-O-glucoside groups with homocysteine. All animals were fed by a high-fat diet, modified by AIN-93, containing 0.5% of cholesterol and 45% of fat. Luteolin and luteolin-7-O-glycoside were given daily by gavage for 5 weeks (50 mg/kg BW, respectively). To induce hyperhomocysteinemia, homocysteine was provided as a drinking water (0.9g/L). Administration of homocysteine did not affect body weight gain, feed intake and feed efficiency ratio among groups. Homocysteine feeding sharply increased serum concentrations of homocysteine and triglyceride as well as adhesion molecules including monocyte chemoattractant protein-1 and vascular cell adhesion molecule-1, which were attenuated by the administration of luteolin and luteolin-7-O-glucoside (p < 0.05). Homocysteine administration produced development of atherosclerotic process by the induction of hepatic inducible nitric oxide synthase and cyclooxygenase-2 as well as aortic intercellular adhesion molecule expressions along with diminished expressions of antioxidative enzymes, such as hepatic glutathione reductase (GR), aortic GR and glutathione peroxidase (p < 0.05). Administration of both flavones down-regulated expressions of inflammatory mediators and adhesion molecules as well as up-regulated expressions of antioxidative enzymes (p < 0.05). These data were in accordance with the histopathological observations which were analyzed by hematoxylin and eosin (H&E) stain and immunohistochemistry. In a comparison of both agents, luteolin more potently attenuated inflammation and oxidative stress than luteolin-7-O-glucoside. These results exhibit that luteolin and luteolin-7-O-glycoside ameliorated atherogenic processes through the regulation of inflammation and oxidative stress in ApoE knockout mice with hyperhomocysteinemia. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government of MOE (No 201704340001).

Coronary flow and oxidative stress during local anaphylactic reaction in isolated mice heart: the role of nitric oxide (NO)

2015 ◽  
Vol 412 (1-2) ◽  
pp. 221-227
Author(s):  
Vesna Milicic ◽  
Vladimir Zivkovic ◽  
Nevena Jeremic ◽  
Nebojsa Arsenijevic ◽  
Dragan Djuric ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Anaphylactic Reaction ◽  
Coronary Flow ◽  
And Oxidative Stress

scholarly journals Low body mass index is a risk factor forimpaired endothelium-dependent vasodilation in humans: role of nitric oxide and oxidative stress

2003 ◽  
Vol 42 (2) ◽  
pp. 256-263 ◽  
Author(s):  
Yukihito Higashi ◽  
Shota Sasaki ◽  
Keigo Nakagawa ◽  
Masashi Kimura ◽  
Kensuke Noma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Body Mass Index ◽  
Risk Factor ◽  
Body Mass ◽  
Low Body Mass Index ◽  
And Oxidative Stress

scholarly journals Review of polymorphisms, associated with cardiovascular diseases

2021 ◽  
pp. 333-338
Author(s):  
A. A. Akopyan ◽  
I. D. Strazhesko ◽  
O. N. Tkacheva ◽  
A. P. Yesakova ◽  
I. A. Orlova
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Cardiovascular Diseases ◽  
Chronic Inflammation ◽  
Gene Polymorphisms ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
System Activation ◽  
And Oxidative Stress

In this research we examined studies of gene polymorphisms, associated with cardiovascular diseases through renin-angiotensin-aldosterone system activation (AGT с.521С>Т, AСE Ins>Del), nitric oxide decline (NOS3 с.894G>T), chronic inflammation (TNF -238G>A, MMP9 -1562С>T) and oxidative stress (CYBA c.214Т>С).

scholarly journals Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: Possible therapeutic targets?

2013 ◽  
Vol 140 (3) ◽  
pp. 239-257 ◽  
Author(s):  
Luc Rochette ◽  
Julie Lorin ◽  
Marianne Zeller ◽  
Jean-Claude Guilland ◽  
Luc Lorgis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Cardiovascular Diseases ◽  
Nitric Oxide Synthase ◽  
Therapeutic Targets ◽  
Oxide Synthase ◽  
And Oxidative Stress
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