Consumption of a single serving of red raspberries per day reduces metabolic syndrome parameters in high-fat fed mice

2017 ◽  
Vol 8 (11) ◽  
pp. 4081-4088 ◽  
Author(s):  
T. Luo ◽  
O. Miranda-Garcia ◽  
G. Sasaki ◽  
N. F. Shay
Keyword(s):  
Metabolic Syndrome ◽  
Mouse Model ◽  
High Fat Diet ◽  
High Fat ◽  
Daily Serving

Intake of one daily serving of raspberry ameliorates the symptoms of metabolic syndrome in a high fat diet fed C57BL/6J mouse model.

PBI-4050 reduces liver damage and fibrosis in a high-fat diet mouse model of obesity and metabolic syndrome

2017 ◽  
Vol 66 (1) ◽  
pp. S165
Author(s):  
B. Grouix ◽  
F. Sarra-Bournet ◽  
M. Tremblay ◽  
A. Felton ◽  
P. Laurin ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Mouse Model ◽  
Liver Damage ◽  
High Fat Diet ◽  
High Fat

PBI-4547 Improves Glucose Metabolism and Insulin Resistance, and Reduces Liver Damage in a High-Fat Diet Mouse Model of Obesity and Metabolic Syndrome

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1858-P
Author(s):  
MARTIN LEDUC ◽  
BRIGITTE GROUIX ◽  
MIKAËL TREMBLAY ◽  
LIETTE GERVAIS ◽  
FRANÇOIS SARRA-BOURNET ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Glucose Metabolism ◽  
Mouse Model ◽  
Liver Damage ◽  
High Fat Diet ◽  
High Fat

scholarly journals Intermittent restraint-induced sympathetic activation attenuates hepatic steatosis and inflammation in a high-fat diet-fed mouse model

2019 ◽  
Vol 317 (6) ◽  
pp. G811-G823
Author(s):  
Sung Bae Lee ◽  
Hyeong Geug Kim ◽  
Jin Seok Lee ◽  
Won Yong Kim ◽  
Myong Min Lee ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Mouse Model ◽  
High Fat Diet ◽  
Restraint Stress ◽  
Sympathetic Activation ◽  
Severe Stress ◽  
High Fat ◽  
Stress Group

Nonalcoholic fatty liver disease (NAFLD) is very prevalent worldwide and is associated with insulin resistance and metabolic syndrome. Stress is a physiological and biological response to maintain homeostasis of the body against stressors while severe stress response is an important contributor to various illnesses, including metabolic syndrome and brain disorders. We have evaluated the effects of intermittent restraint stress on NAFLD in a high-fat diet (HFD)-fed mouse model. C57/BL6 mice had free access to a 60% HFD for 8 wk, with or without intermittent restraint stress (3 h) conducted three times a week. HFD administration increased fat accumulation in liver tissues. Unlike the stressed standard diet group, the levels of hepatic total cholesterol and triglycerides were significantly ameliorated in the HFD with stress group compared with the HFD alone group. These beneficial results were in accordance with serum levels of liver enzymes (aspartate transaminase, alanine transaminase) and hepatic levels of TNF-α and oxidative stress parameters (reactive oxygen species, nitric oxide, and malondialdehyde). The intermittent restraint stress significantly attenuated the HFD-derived alterations in serum insulin levels, hepatic protein kinase B activity, and gene expression, especially related to lipogenesis. This intermittent restraint stress also elevated the serum epinephrine concentration and activated the adrenergic receptor β2 or β3 in livers or white adipose tissue (WAT). Activation of energy expenditure markers (uncoupling protein 1, peroxisome proliferator-activated receptor-γ coactivator-1α) in brown adipose tissue and the browning of WAT were also observed in the HFD with stress group. Taken together, our findings showed the beneficial effects of sympathetic activation by intermittent restraint stress on HFD-induced hepatic steatosis and partial inflammation. NEW & NOTEWORTHY In modern society, stress is a part of daily life, and a certain level of stress is inevitable to most of the general population. Uncontrolled severe stress is obviously harmful; however, certain kind/level of stress could be beneficial on lipid metabolism via sympathetic activation. Our data suggest that a sympathetic activation by intermittent restraint stress could play a positive role in maintaining the balance of hepatic lipid metabolism, especially under high-fat diet conditions.

scholarly journals High-fat diet feeding affects osteoarthritis progression in a surgical mouse model with aspects of metabolic syndrome

2016 ◽  
Vol 24 ◽  
pp. S375
Author(s):  
A. Kozijn ◽  
F. van den Ham ◽  
S. Ravipati ◽  
P. Pousini ◽  
D. Barrett ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Mouse Model ◽  
High Fat Diet ◽  
High Fat ◽  
Osteoarthritis Progression

scholarly journals A Mouse Model of Metabolic Syndrome: Insulin Resistance, Fatty Liver and Non-Alcoholic Fatty Pancreas Disease (NAFPD) in C57BL/6 Mice Fed a High Fat Diet

2010 ◽  
Vol 46 (3) ◽  
pp. 212-223 ◽  
Author(s):  
Julio C. Fraulob ◽  
Rebeca Ogg-Diamantino ◽  
Caroline Fernandes-Santos ◽  
Marcia Barbosa Aguila ◽  
Carlos A. Mandarim-de-Lacerda
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Mouse Model ◽  
Fatty Liver ◽  
High Fat Diet ◽  
High Fat ◽  
Pancreas Disease ◽  
Fatty Pancreas

Sex differences in response to a high fat diet in an Alzheimer’s Disease mouse model

2018 ◽  
Author(s):  
Alejandra Freire Fernández-Regatillo ◽  
María L. de Ceballos ◽  
Jesús Argente ◽  
Sonia Díaz Pacheco ◽  
Clara González Martínez
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sex Differences ◽  
Mouse Model ◽  
High Fat Diet ◽  
High Fat
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