Dietary linoleic acid intake and blood inflammatory markers: a systematic review and meta-analysis of randomized controlled trials

2017 ◽  
Vol 8 (9) ◽  
pp. 3091-3103 ◽  
Author(s):  
Hang Su ◽  
Ruijie Liu ◽  
Ming Chang ◽  
Jianhua Huang ◽  
Xingguo Wang
Keyword(s):  
Systematic Review ◽  
Linoleic Acid ◽  
Inflammatory Markers ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Dietary Linoleic Acid ◽  
Acute Phase Reactants ◽  
Randomized Controlled ◽  
Acid Intake ◽  
Linoleic Acid Intake

This meta-analysis aims at investigating the effect of linoleic acid intake on inflammatory cytokines, acute phase reactants and adhesion molecules.

Effect of ginger (Zingiber officinale) on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials

Cytokine ◽  
2020 ◽  
Vol 135 ◽  
pp. 155224 ◽  
Author(s):  
Mojgan Morvaridzadeh ◽  
Siavash Fazelian ◽  
Shahram Agah ◽  
Maryam Khazdouz ◽  
Mehran Rahimlou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Inflammatory Markers ◽  
Meta Analysis ◽  
Zingiber Officinale ◽  
Controlled Trials ◽  
Randomized Controlled

An updated systematic review and dose-response meta-analysis of the randomized controlled trials on the effects of Alpha-Lipoic acid supplementation on inflammatory biomarkers

2021 ◽  
pp. 1-14
Author(s):  
Mahdi Vajdi ◽  
Mahsa Mahmoudi-Nezhad ◽  
Mahdieh Abbasalizad Farhangi
Keyword(s):  
Systematic Review ◽  
Lipoic Acid ◽  
Dose Response ◽  
Subgroup Analysis ◽  
Inflammatory Markers ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Alpha Lipoic Acid ◽  
Randomized Controlled ◽  
Tnf Α

Abstract. Data about the effects of alpha-lipoic acid (ALA) supplementation on inflammatory markers are inconsistent. This systematic review and dose-response meta-analysis of randomized controlled trials was performed to summarize the effects of ALA supplementation on inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in adults. A comprehensive literature search was conducted in the electronic databases of PubMed, Web of Science, ProQuest, Embase, and SCOPUS from inception to February 2020. Among all of the eligible studies, 20 articles were selected. The weighted mean differences (WMD) and 95% confidence intervals (CI) were calculated to evaluate the pooled effect size. Between-study heterogeneity was evaluated using Cochran’s Q test and I2. Subgroup analysis was done to evaluate the potential sources of heterogeneity. The dose-response relationship was evaluated using fractional polynomial modeling. Twenty eligible studies with a total sample size of 947 participants were included in the current meta-analysis. The findings of the meta-analysis showed that ALA supplementation significantly reduced CRP (WMD: −0.69 mg/L, 95% CI: −1.13, −0.26, P=0.002), IL-6 (WMD: −1.83 pg/ml, 95% CI: −2.90, −0.76, P=0.001), and TNF-α concentrations (WMD: −0.45 pg/ml, 95% CI: −0.85, −0.04, P=0.032). No evidence of departure from linearity was observed between dose and duration of the ALA supplementation on serum CRP, IL-6 and TNF-α concentration. In subgroup analysis, ALA dosage, baseline concentrations of the parameter, sample size, and gender were considered as possible sources of heterogeneity. In summary, ALA supplementation improves inflammatory markers without any evidence of non-linear association to dose or duration of the trial.

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