Chromatographic and mass spectrometry analysis of wheat flour prolamins, the causative compounds of celiac disease

2017 ◽  
Vol 8 (8) ◽  
pp. 2712-2721 ◽  
Author(s):  
M. R. Perez-Gregorio ◽  
R. Días ◽  
N. Mateus ◽  
V. de Freitas
Keyword(s):  
Mass Spectrometry ◽  
Immune Response ◽  
Celiac Disease ◽  
Wheat Flour ◽  
Adaptive Immune Response ◽  
Mass Spectrometry Analysis ◽  
Spectrometry Analysis ◽  
Adaptive Immune ◽  
Gluten Peptides

Immunogenic gluten peptides trigger Celiac Disease (CD), an adaptive immune response in genetically predisposed individuals.

scholarly journals Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response

2022 ◽  
Vol 12 ◽  
Author(s):  
Elisa Pesce ◽  
Nicola Manfrini ◽  
Chiara Cordiglieri ◽  
Spartaco Santi ◽  
Alessandra Bandera ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Mass Spectrometry ◽  
Immune Response ◽  
Immune System ◽  
Adaptive Immune Response ◽  
Active Role ◽  
Extracellular Vesicle ◽  
Pathological State ◽  
Cell Responses ◽  
Adaptive Immune

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by beta-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has rapidly spread across the globe starting from February 2020. It is well established that during viral infection, extracellular vesicles become delivery/presenting vectors of viral material. However, studies regarding extracellular vesicle function in COVID-19 pathology are still scanty. Here, we performed a comparative study on exosomes recovered from the plasma of either MILD or SEVERE COVID-19 patients. We show that although both types of vesicles efficiently display SARS-CoV-2 spike-derived peptides and carry immunomodulatory molecules, only those of MILD patients are capable of efficiently regulating antigen-specific CD4+ T-cell responses. Accordingly, by mass spectrometry, we show that the proteome of exosomes of MILD patients correlates with a proper functioning of the immune system, while that of SEVERE patients is associated with increased and chronic inflammation. Overall, we show that exosomes recovered from the plasma of COVID-19 patients possess SARS-CoV-2-derived protein material, have an active role in enhancing the immune response, and possess a cargo that reflects the pathological state of patients in the acute phase of the disease.

The adaptive immune response in celiac disease

2012 ◽  
Vol 34 (4) ◽  
pp. 523-540 ◽  
Author(s):  
Shuo-Wang Qiao ◽  
Rasmus Iversen ◽  
Melinda Ráki ◽  
Ludvig M. Sollid
Keyword(s):  
Immune Response ◽  
Celiac Disease ◽  
Adaptive Immune Response ◽  
Adaptive Immune

Mass spectrometry analysis of gliadins in celiac disease

2007 ◽  
Vol 42 (12) ◽  
pp. 1531-1548 ◽  
Author(s):  
Pasquale Ferranti ◽  
Gianfranco Mamone ◽  
Gianluca Picariello ◽  
Francesco Addeo
Keyword(s):  
Mass Spectrometry ◽  
Celiac Disease ◽  
Mass Spectrometry Analysis ◽  
Spectrometry Analysis
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