Comprehensive evaluation of the cytotoxicity of CdSe/ZnS quantum dots in Phanerochaete chrysosporium by cellular uptake and oxidative stress

2017 ◽  
Vol 4 (10) ◽  
pp. 2018-2029 ◽  
Author(s):  
Liang Hu ◽  
Jia Wan ◽  
Guangming Zeng ◽  
Anwei Chen ◽  
Guiqiu Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Quantum Dots ◽  
Phanerochaete Chrysosporium ◽  
Cellular Uptake ◽  
Comprehensive Evaluation ◽  
Physiological Responses ◽  
And Oxidative Stress

The cellular uptake of QDs and the induced physiological responses in an organism are investigated.

scholarly journals Astrocyte-Targeted Transporter-Utilizing Derivatives of Ferulic Acid Can Have Multifunctional Effects Ameliorating Inflammation and Oxidative Stress in the Brain

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Ahmed Montaser ◽  
Johanna Huttunen ◽  
Sherihan Abdelhamid Ibrahim ◽  
Kristiina M. Huttunen
Keyword(s):  
Oxidative Stress ◽  
Ferulic Acid ◽  
Cellular Uptake ◽  
Parent Drug ◽  
Beneficial Effects ◽  
Multifunctional Compounds ◽  
Low Concentrations ◽  
Amyloid Accumulation ◽  
The Brain ◽  
And Oxidative Stress

Ferulic acid (FA) is a natural phenolic antioxidant, which can exert also several other beneficial effects to combat neuroinflammation and neurodegenerative diseases, such as Alzheimer’s disease. One of these properties is the inhibition of several enzymes and factors, such as β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1), cyclooxygenases (COXs), lipoxygenases (LOXs), mammalian (or mechanistic) target for rapamycin (mTOR), and transcription factor NF-κB. We have previously synthesized three L-type amino acid transporter 1- (LAT1-) utilizing FA-derivatives with the aim to develop brain-targeted prodrugs of FA. In the present study, the cellular uptake and bioavailability of these FA-derivatives were evaluated in mouse primary astrocytic cell cultures together with their inhibitory effects towards BACE1, COX/LOX, mTOR, NF-κB, acetylcholinesterase (AChE), and oxidative stress. According to the results, all three FA-derivatives were taken up 200–600 times more effectively at 10 μM concentration into the astrocytes than FA, with one derivative having a high intracellular bioavailability (Kp,uu), particularly at low concentrations. Moreover, all of the derivatives were able to inhibit BACE1, COX/LOX, AChE, and oxidative stress measured as decreased cellular lipid peroxidation. Furthermore, one of the derivatives modified the total mTOR amount. Therefore, these derivatives have the potential to act as multifunctional compounds preventing β-amyloid accumulation as well as combating inflammation and reducing oxidative stress in the brain. Thus, this study shows that converting a parent drug into a transporter-utilizing derivative not only may increase its brain and cellular uptake, and bioavailability but can also broaden the spectrum of pharmacological effects elicited by the derivative.

scholarly journals The molecular mechanisms associated with the physiological responses to inflammation and oxidative stress in cardiovascular diseases

2020 ◽  
Vol 12 (4) ◽  
pp. 947-968 ◽  
Author(s):  
Saltanat Zhazykbayeva ◽  
Steffen Pabel ◽  
Andreas Mügge ◽  
Samuel Sossalla ◽  
Nazha Hamdani
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Diseases ◽  
Molecular Mechanisms ◽  
Physiological Responses ◽  
And Oxidative Stress

Cadmium selenide (CdSe) quantum dots cause genotoxicity and oxidative stress in Allium cepa plants

2021 ◽  
Vol 865 ◽  
pp. 503338
Author(s):  
Ritesh Banerjee ◽  
Priya Goswami ◽  
Manoswini Chakrabarti ◽  
Debolina Chakraborty ◽  
Amitava Mukherjee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Quantum Dots ◽  
Cadmium Selenide ◽  
Allium Cepa ◽  
Cdse Quantum Dots ◽  
And Oxidative Stress

scholarly journals Preterm birth and oxidative stress: Effects of acute physical exercise and hypoxia physiological responses

Redox Biology ◽  
2018 ◽  
Vol 17 ◽  
pp. 315-322 ◽  
Author(s):  
Agnès Martin ◽  
Camille Faes ◽  
Tadej Debevec ◽  
Chantal Rytz ◽  
Grégoire Millet ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Preterm Birth ◽  
Physical Exercise ◽  
Physiological Responses ◽  
Stress Effects ◽  
Acute Physical Exercise ◽  
And Oxidative Stress
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