Improving the relevance and efficiency of human exposure assessments within the process of regulatory risk assessment

2018 ◽  
Vol 20 (1) ◽  
pp. 12-19 ◽  
Author(s):  
Chris Money
Keyword(s):  
Risk Assessment ◽  
Exposure Assessment ◽  
Information Acquisition ◽  
Human Exposure ◽  
Assessment Process ◽  
Human Exposure Assessment ◽  
Regulatory Risk Assessment

The article explores how tiered and targeted information acquisition can improve the effectiveness of the human exposure assessment process.

Human Exposure Assessment II: Quantifying and Reducing the Uncertainties

1992 ◽  
Vol 8 (5) ◽  
pp. 321-342 ◽  
Author(s):  
Gary K. Whitmyre ◽  
Jeffrey H. Driver ◽  
Michael E. Ginevan ◽  
Robert G. Tardiff ◽  
Scott R. Baker
Keyword(s):  
Exposure Assessment ◽  
Human Exposure ◽  
Absorbed Dose ◽  
Assessment Process ◽  
Alternative Methods ◽  
Bivariate Analysis ◽  
Activity Data ◽  
Time Activity ◽  
Exposed Individual ◽  
Human Exposure Assessment

Alternative methods of human exposure assessment that reduce and/or allow quantification of the uncertainties associated with exposure estimates are surveyed and illustrated. These alternative approaches include (1) use of more appropriate exposure parameter default values rather than values that result in extreme exposure estimates; (2) incorporation of time-activity data to better define appropriate exposure duration values; (3) the use of reasonable exposure scenarios rather than the traditional Maximally Exposed Individual (MEI) approach; (4) the use of stochastic approaches such as Monte Carlo-based and information analysis-based methods; (5) use of bivariate analysis to identify the extent to which interdependencies between different exposure parameters affect the distribution of exposure estimates; (6) use of less-than-lifetime exposure and risk assessment; and (7) incorporation of physiological considerations relevant to absorbed dose estimation, including route-specific impacts, use of improved absorption factors, and application of pharmacokinetic models. Other ways to improve the exposure assessment process, including assuring statistical equivalency in comparing different exposure estimates and incorporation of sensitive subpopulation considerations are also discussed, as are key research needs.

Intra-urban variability of air pollution in Windsor, Ontario—Measurement and modeling for human exposure assessment

2008 ◽  
Vol 106 (1) ◽  
pp. 7-16 ◽  
Author(s):  
Amanda J. Wheeler ◽  
Marc Smith-Doiron ◽  
Xiaohong Xu ◽  
Nicolas L. Gilbert ◽  
Jeffrey R. Brook
Keyword(s):  
Air Pollution ◽  
Exposure Assessment ◽  
Human Exposure ◽  
Human Exposure Assessment

Occurrence of alternative flame retardants in indoor dust from New Zealand: Indoor sources and human exposure assessment

Chemosphere ◽  
2012 ◽  
Vol 88 (11) ◽  
pp. 1276-1282 ◽  
Author(s):  
Nadeem Ali ◽  
Alin C. Dirtu ◽  
Nele Van den Eede ◽  
Emma Goosey ◽  
Stuart Harrad ◽  
...  
Keyword(s):  
New Zealand ◽  
Exposure Assessment ◽  
Human Exposure ◽  
Flame Retardants ◽  
Indoor Dust ◽  
Indoor Sources ◽  
Human Exposure Assessment
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