The design of synthetic superoxide dismutase mimetics: seven-coordinate water soluble manganese(ii) and iron(ii) complexes and their superoxide dismutase-like activity studies

2017 ◽  
Vol 46 (41) ◽  
pp. 14186-14191 ◽  
Author(s):  
Ovender Singh ◽  
Nidhi Tyagi ◽  
Marilyn M. Olmstead ◽  
Kaushik Ghosh
Keyword(s):  
Superoxide Dismutase ◽  
Water Soluble ◽  
Superoxide Dismutase Mimetics ◽  
Pentadentate Ligand

Manganese(ii) and iron(ii) complexes derived from a pentadentate ligand have been characterized and these were utilized for superoxide dismutase-like activity studies.

Neuroprotection against hypoxia-ischemia in neonatal rat brain by novel superoxide dismutase mimetics

2003 ◽  
Vol 346 (1-2) ◽  
pp. 41-44 ◽  
Author(s):  
Katsuyoshi Shimizu ◽  
Nishadi Rajapakse ◽  
Takashi Horiguchi ◽  
R.Mark Payne ◽  
David W. Busija
Keyword(s):  
Superoxide Dismutase ◽  
Rat Brain ◽  
Neonatal Rat ◽  
Hypoxia Ischemia ◽  
Superoxide Dismutase Mimetics ◽  
Neonatal Rat Brain

Comparison of the effects of the superoxide dismutase mimetics EUK-134 and tempol on paraquat-induced nephrotoxicity

2007 ◽  
Vol 43 (4) ◽  
pp. 528-534 ◽  
Author(s):  
Mohamed Samai ◽  
Martyn A. Sharpe ◽  
Paul R. Gard ◽  
Prabal K. Chatterjee
Keyword(s):  
Superoxide Dismutase ◽  
Superoxide Dismutase Mimetics

scholarly journals The activity of superoxide-dismutase in animal cell culture CHO-K1 after treatment with fullerenol and mytomicine C

2009 ◽  
Vol 63 (3) ◽  
pp. 143-149 ◽  
Author(s):  
Visnja Bogdanovic ◽  
Marija Slavic ◽  
Jasminka Mrdjanovic ◽  
Slavica Solajic ◽  
Aleksandar Djordjevic
Keyword(s):  
Superoxide Dismutase ◽  
Mammalian Cells ◽  
Animal Cell ◽  
Water Soluble ◽  
Cytotoxic Agents ◽  
Antioxidant Defenses ◽  
Free Radical Scavengers ◽  
Sod Activity

Eukaryotic cell survives in predominantly reduced conditions. Homeostasis of cellular redox system is an imperative of cell surviving and its normal metabolism. ROS are well recognized for playing a dual role as both deleterious and beneficial species, since they can be either harmful or beneficial to living systems. These species are mutagenic compounds known to lead to DNA damage, favor cell transformation, and contribute to the development of a variety of malignant diseases. All the effects of oxidants are influenced by the cellular antioxidant defenses. This multilayer system consists of low molecular weight components and several antioxidant enzymes. Superoxide dismutases (SODs) are the only enzymes dismuting superoxide radicals. Mitomycin C, a cross-linking agent, demonstrated genotoxicity in all in vitro and in vivo test systems in mammalian cells and animals. Water-soluble fullerenes are well known as cytotoxic agents for many cell lines in vitro. At the other side, fullerenols are good free radical scavengers and antioxidants both in vitro and in vivo. This paper investigates the effects of fullerenol on survival and fullerenol/ /mytomicine (MMC) treatment on superoxide-dismutase (SOD) activity in CHO-K1 cells. Samples were treated 3 and 24 h with fullerenol (C60(OH)24) at concentration range 0.01-0.5 mg/mL and survival was monitored with dye exclusion test (DET). The activity of total SOD was estimated in samples treated with chosen concentrations of fullerenol and MMC (0.5 and 0.1 mg/mL) after 3 and 24 h of cell incubation. Increasing of C60(OH)24 concentration leads to decreasing of percent of surviving cells 3 and 24 h after incubation. The activity of total SOD enhanced with higher concentration of fullerenol, while decreased in the highest concentration at both experimental points. In samples treated with MMC, as well as in samples treated with fullerenol (0.0625 mg/mL) + MMC was noticed boost in total SOD activity in comparison with controls. Treatment with fullerenol decreased SOD activity in rest of samples treated with MMC. Decreased activity of superoxide-dismutase in almost all samples treated with fullerenol and MMC might be contributed to antioxidative properties of fullerenol. Increased enzyme level at concentration of 0.0625 mg/mL may be due to its prooxidative activity.

scholarly journals Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics

Autophagy ◽  
2019 ◽  
Vol 16 (2) ◽  
pp. 289-312 ◽  
Author(s):  
Annadurai Thangaraj ◽  
Palsamy Periyasamy ◽  
Ming-Lei Guo ◽  
Ernest T. Chivero ◽  
Shannon Callen ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Microglial Activation ◽  
Mitochondrial Damage ◽  
Superoxide Dismutase Mimetics

scholarly journals Effects of superoxide dismutase mimetics on the activity of nitric oxide in rat aorta

1999 ◽  
Vol 127 (5) ◽  
pp. 1159-1164 ◽  
Author(s):  
Andrew MacKenzie ◽  
Silvia Filippini ◽  
William Martin
Keyword(s):  
Nitric Oxide ◽  
Superoxide Dismutase ◽  
Rat Aorta ◽  
Superoxide Dismutase Mimetics

Selective cell death by water-soluble Fe-porphyrins with superoxide dismutase (SOD) activity

2002 ◽  
Vol 91 (2) ◽  
pp. 349-355 ◽  
Author(s):  
Nobuyoshi Kasugai ◽  
Toru Murase ◽  
Toshiyuki Ohse ◽  
Shoji Nagaoka ◽  
Hiroyoshi Kawakami ◽  
...  
Keyword(s):  
Cell Death ◽  
Superoxide Dismutase ◽  
Water Soluble ◽  
Sod Activity

scholarly journals Superoxide radical induces sclerotial differentiation in filamentous phytopathogenic fungi: a superoxide dismutase mimetics study

Microbiology ◽  
2010 ◽  
Vol 156 (3) ◽  
pp. 960-966 ◽  
Author(s):  
Ioannis Papapostolou ◽  
Christos D. Georgiou
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Sclerotinia Sclerotiorum ◽  
Superoxide Radical ◽  
Sclerotium Rolfsii ◽  
Phytopathogenic Fungi ◽  
Indirect Indicator ◽  
Superoxide Dismutase Mimetics ◽  
Sclerotial Differentiation

This study shows that the superoxide radical (O2 •−), a direct indicator of oxidative stress, is involved in the differentiation of the phytopathogenic filamentous fungi Rhizoctonia solani, Sclerotinia sclerotiorum, Sclerotium rolfsii and Sclerotinia minor, shown by using superoxide dismutase (SOD) mimetics to decrease their sclerotial differentiation. The production rate of O2 •− and SOD levels in these fungi, as expected, were significantly lowered by the SOD mimetics, with concomitant decrease of the indirect indicator of oxidative stress, lipid peroxidation.

Superoxide dismutase mimetics. Part 2: synthesis and structure–Activity relationship of glyoxylate- and glyoxamide-Derived metalloporphyrins

2003 ◽  
Vol 11 (13) ◽  
pp. 2695-2707 ◽  
Author(s):  
Michael P Trova ◽  
Polivina Jolicia F Gauuan ◽  
Anthony D Pechulis ◽  
Stephen M Bubb ◽  
Stephen B Bocckino ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of ◽  
Superoxide Dismutase Mimetics
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