scholarly journals Highly active group 11 metal complexes with α-hydrazidophosphonate ligands

2017 ◽  
Vol 46 (40) ◽  
pp. 13745-13755 ◽  
Author(s):  
Daniel Salvador-Gil ◽  
Lourdes Ortego ◽  
Raquel P. Herrera ◽  
Isabel Marzo ◽  
M. Concepción Gimeno
Keyword(s):  
Metal Complexes ◽  
Cytotoxic Activity ◽  
Lung Carcinoma ◽  
Copper Complexes ◽  
Carcinoma Cell ◽  
Highly Active ◽  
Carcinoma Cell Lines ◽  
Metal Atoms ◽  
A549 Lung Carcinoma Cell ◽  
A549 Lung

Unprecedented α-hydrazidophosphonate group 11 metal complexes have been prepared, with various coordination modes of ligands to metal atoms. They present an excellent cytotoxic activity in HeLa (cervical carcinoma) and A549 (lung carcinoma) cell lines, with IC50values among the lowest found in silver or copper complexes.

The role of nitric oxide in paraquat-induced cytotoxicity in the human A549 lung carcinoma cell line

2001 ◽  
Vol 34 (2) ◽  
pp. 193-202 ◽  
Author(s):  
Masafumi Tomita ◽  
Toshiko Okuyama ◽  
Tetsuya Ishikawa ◽  
Kazuo Hidaka ◽  
Tsutomu Nohno
Keyword(s):  
Nitric Oxide ◽  
Cell Line ◽  
Lung Carcinoma ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Lung Carcinoma Cell Line ◽  
A549 Lung Carcinoma Cell ◽  
Human A549 ◽  
A549 Lung

scholarly journals Synthesis of CEG-AgNPs as a Promising MMPs/COX-2/Bcl-2 Signaling Pathway Modulator in BaP-Induced Lung Carcinoma

2022 ◽  
Vol 34 (2) ◽  
pp. 289-296
Author(s):  
Ahmed A. Emara ◽  
Ahmed M. Darwesh ◽  
Mohamed A. Mostafa ◽  
Ahmed A. Ahmed ◽  
Khaled W. Rashad ◽  
...  
Keyword(s):  
Gene Expression ◽  
Anticancer Activity ◽  
Cell Line ◽  
Lung Carcinoma ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Lung Carcinoma Cell Line ◽  
A549 Lung Carcinoma Cell ◽  
Cox 2 ◽  
A549 Lung

Cucurbitacins are a class of highly oxidized tetracyclic triterpenoids. It’s hydrophobic properties and poor solubility in water, polymeric micellar systems exhibited improved antitumor efficacy because of a better solubilization and targeting after local and/or systemic administration. The aim of the present work was to evaluate the anticancer activity of CEG-AgNPs against benzo[a]pyren (BaP)-induced lung carcinoma. CEG-AgNPs was prepared, characterized and evaluated for its cytotoxic activity against A549 lung carcinoma cell line. Also, the anticancer activity of CEG-AgNPs (70.25 mg/kg) against BaP-induced lung carcinoma was evaluated in vivo, using 30 adult mice for 43 days. IC50 of CEG-AgNPs against A549 lung carcinoma cell line were approximately 94.47 μg/mL. Administration of BaP (50 mg/kg b.w.) to mice induced lung carcinoma with a significant increase in lung MMP-2, MMP-9, MMP-12, MDA, IL-6 and NF-κB as well as significant decreased in lung CAT, GPx and GSH level. Also, treatment with BaP produced significant increase in lung VEGF-C, COX-2 and Bcl-2 gene expression as compared to control group. Daily oral administration of CEG-AgNPs to mice treated with BaP showed a significant protection against-induced increase in lung MMP-2, MMP-9, MMP-12, MDA, IL-6 and NF-κB levels. The treatment also resulted in a significant increase in lung CAT, GPx and GSH level. In addition, the CEG-AgNPs could inhibit lung VEGF-C, COX-2 and Bcl-2 gene expression as compared to BaP treated mice. The histological and MRI examination showed that a significant normalization has been observed through in CEG-AgNPs treated mice. The biochemical, histological and MRI results showed that CEG-AgNPs have potent anticancer activity against BaP-induced lung carcinoma through modulating multiple cellular behaviours and signaling pathways leading to the suppression of adaptive immune responses.

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