scholarly journals Metal complexes for multimodal imaging of misfolded protein-related diseases

2017 ◽  
Vol 46 (42) ◽  
pp. 14461-14474 ◽  
Author(s):  
S. Lacerda ◽  
J.-F. Morfin ◽  
C. F. G. C. Geraldes ◽  
É. Tóth
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Metal Complexes ◽  
Cerebral Amyloid Angiopathy ◽  
Type Ii Diabetes ◽  
Multimodal Imaging ◽  
Amyloid Angiopathy ◽  
Misfolded Protein ◽  
Type Ii ◽  
Cerebral Amyloid ◽  
Lateral Sclerosis

Aggregation of misfolded proteins and progressive polymerization of otherwise soluble proteins is a common hallmark of several highly debilitating and increasingly prevalent diseases, including amyotrophic lateral sclerosis, cerebral amyloid angiopathy, type II diabetes and Parkinson's, Huntington's and Alzheimer's diseases.

Type II diabetes mellitus and the incidence of amyotrophic lateral sclerosis

2019 ◽  
Vol 266 (9) ◽  
pp. 2233-2243 ◽  
Author(s):  
Ching-Piao Tsai ◽  
Johnny Kuang-Wu Lee ◽  
Charles Tzu-Chi Lee
Keyword(s):  
Diabetes Mellitus ◽  
Amyotrophic Lateral Sclerosis ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Lateral Sclerosis

Type II diabetes mellitus and amyotrophic lateral sclerosis: genetic overlap, causality, and mediation

2021 ◽  
Author(s):  
Haimiao Chen ◽  
Jinhui Zhang ◽  
Ting Wang ◽  
Shuo Zhang ◽  
Qingwei Lai ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Mediation Analysis ◽  
Type Ii Diabetes ◽  
Disease Risk ◽  
Mediation Effect ◽  
Type Ii ◽  
Obesity Class ◽  
Mediating Role ◽  
Lateral Sclerosis

Abstract Objective To disentangle the nature of the inverse relationship between type II diabetes (T2D) mellitus and amyotrophic lateral sclerosis (ALS). Methods Depending on summary statistics of T2D (n=898,130) and ALS (n=80,610), we estimated the genetic correlation between them and prioritized pleiotropic genes through a multiple-tissue eQTL weighted integrative analysis and the ccFDR method. We implemented Mendelian randomization (MR) analyses to evaluate the causal relationship between the two diseases. A mediation analysis was performed to assess the mediating role of T2D in the pathway from T2D-related glycemic/anthropometric traits to ALS. Results We found supportive evidence of common genetic foundation between T2D and ALS (rg=-0.223, p=0.004), and identified eight pleiotropic genes (ccFDR<0.10). The MR analysis confirmed that T2D exhibited a neuroprotective effect on ALS, leading to an approximately 5% (95% confidence intervals 0~9.6%, p=0.038) reduction in disease risk. In contrast, no substantial evidence was observed that supported the causal influence of ALS on T2D. The mediation analysis revealed T2D can also serve as an active mediator for several glycemic/anthropometric traits, including high-density lipoprotein cholesterol, overweight, body mass index, obesity class 1, obesity class 2, with the mediation effect estimated to be 0.024, -0.022, -0.041, -0.016, and -0.012, respectively. Conclusion We provided new evidence supporting the observed inverse link between T2D and ALS, and revealed that shared genetic component and causal association commonly drove such relationship. We also demonstrated the mediating role of T2D standing in the pathway from T2D-related glycemic/anthropometric traits to ALS.

EVALUATION OF THE UNITED KINGDOM NATIONAL EXTERNAL QUALITY ASSESSMENT SERVICE 2008 (UK NEQAS 2008) GUIDELINES FOR THE DIAGNOSIS OF SUBARACHNOID HEMORRHAGE USING SPECTROPHOTOMETRIC XANTHOCHROMIA: A RETROSPECTIVE STUDY

2009 ◽  
Vol 32 (6S) ◽  
pp. 5
Author(s):  
A Gangloff ◽  
L Nadeau
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cerebral Amyloid Angiopathy ◽  
Viral Encephalitis ◽  
Objective Evaluation ◽  
Final Diagnosis ◽  
Amyloid Angiopathy ◽  
The United Kingdom ◽  
Cerebral Amyloid ◽  
The One ◽  
The Uk

Objective: Evaluation of the UK NEQAS 2008 guidelines for the interpretation of spectrophotometric xanthochromia. Method: A search of the laboratory database for all the xanthochromia test results between May 1st 2008 and May 1st 2009 was performed. Medical charts were reviewed for patients of Hôpital de l’Enfant-Jésus (HEJ) that had at least one detectable pigment (bilirubin, oxyhemoglobin, or methemoglobin). Xanthochromia results obtained with 4 different criteria (Chalmers original, Modified Chalmers, Duiser and UK NEQAS 2008) were compared. Results: We reviewed 41 medical charts (2 patients with duplicate lumbar punctures (LP) for a total of 43 LP). For these 41 patients there were 11 positive xanthochromia results, 5 of which were in concordance with a final diagnosis of subarachnoid hemorrhage (SAH). The diagnosis of the 6 other positive xanthochromia results were as follow: meningeal spread of a lymphoma, cerebral amyloid angiopathy, exertional headache, viral encephalitis with a possibility of petechiaes on the cerebral CT and second LP. Interpretation (negative/positive) of 40/43 LP was identical for the 4 methods. 2 LP were positive with Duiser and UK NEQAS 2008 but negative with Chalmers approaches (final diagnosis: SAH and cerebral amyloid angiopathy). 1 LP was positive only by the Duiser method (viral encephalitis). Conclusions: UK NEQAS 2008 guidelines identified all SAH but are sensitive to traumatic and pathologic meningeal lesions. Except for a case of viral encephalitis with a suspicion of cerebral petechiaes on CT, UK NEQAS 2008 gave xanthochromia results similar to the one in use at HEJ (Duiser). Chalmers original and Modified Chalmers methods missed one of the five SAH.

Cerebral Amyloid Angiopathy in Combination with Paroxysmal Atrial Fibrillation

2020 ◽  
Vol 25 (4) ◽  
pp. 31-37
Author(s):  
A. A. Kornilova ◽  
O. V. Lagoda ◽  
M. M. Tanashyan
Keyword(s):  
Atrial Fibrillation ◽  
Cerebral Amyloid Angiopathy ◽  
Paroxysmal Atrial Fibrillation ◽  
Past History ◽  
Laboratory Data ◽  
Clinical Manifestations ◽  
Cerebral Haemorrhage ◽  
Exclusion Criterion ◽  
Amyloid Angiopathy ◽  
Cerebral Amyloid

The present article addresses the definition of cerebral amyloid angiopathy (CAA) and its symptoms based on the analysis of the medical case; the issues of diagnosis and treatment of this pathology are discussed. The Boston criteria, which became the basis for diagnosis, study of clinical manifestations and progression of CAA and approaches to its therapy, are presented. Methods and modes of neuroimaging, including magnetic resonance imaging (MRI), which verify micro cerebral haemorrhage, are described. At the same time, the role and significance of cardiac arrhythmias in the genesis of ischemic stroke are discussed, and scales for assessing the risk of its occurrence are presented. The observation of the neurological, somatic, neuroimaging, neuropsychological status of a 62-year-old patient confirms quite rare combination of probable CAA, paroxysmal atrial fibrillation and repeated hemorrhagic functional apoplexy (FA). The relevance of the case described, is a complex clinical dilemma based on mutually exclusive recommendations for the pharmacological correction of such conditions. It is emphasized that in many multicenter clinical studies on the effectiveness of antithrombotic medication (antiaggregants, anticoagulants) in the treatment and prevention of ischaemic functional apoplexy , an important exclusion criterion is a hemorrhagic stroke in past history (including the multiple changes in haemostasis indicators). Taking into account the obtained clinical and laboratory data in the dynamics, the tactics of treating the described patient were determined. The results of studies related to the treatment of comorbid pathology that should become the subject of the development of a personalized algorithm for managing patients in each specific case, are discussed.

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