On the turn-inducing properties of asparagine: the structuring role of the amide side chain, from isolated model peptides to crystallized proteins

2018 ◽  
Vol 20 (5) ◽  
pp. 3411-3423 ◽  
Author(s):  
S. Habka ◽  
W. Y. Sohn ◽  
V. Vaquero-Vara ◽  
M. Géléoc ◽  
B. Tardivel ◽  
...  
Keyword(s):  
Gas Phase ◽  
Laser Spectroscopy ◽  
Protein Structures ◽  
Side Chain ◽  
Amide Side Chain ◽  
Model Peptides

The anchoring properties of an asparagine (Asn) residue to its local backbone environment in turn model peptides is characterized using gas phase laser spectroscopy and compared to crystallized protein structures.

Unifying the microscopic picture of His-containing turns: from gas phase model peptides to crystallized proteins

2017 ◽  
Vol 19 (26) ◽  
pp. 17128-17142 ◽  
Author(s):  
Woon Yong Sohn ◽  
Sana Habka ◽  
Eric Gloaguen ◽  
Michel Mons
Keyword(s):  
Gas Phase ◽  
Main Chain ◽  
Protein Structures ◽  
Phase Model ◽  
Side Chain ◽  
Central Position ◽  
Microscopic Picture ◽  
Model Peptides

The presence in crystallized proteins of a local anchoring between the side chain of a His residue, located in the central position of a γ- or β-turn, and its local main chain environment, is assessed by the comparison of protein structures with relevant isolated model peptides.

scholarly journals Role of Side Chain Size in the Formation of Secondary Structures in Model Peptides

2015 ◽  
Vol 108 (2) ◽  
pp. 519a
Author(s):  
Farbod Mahmoudinobar ◽  
Cristiano L. Dias ◽  
Ronen Zangi
Keyword(s):  
Secondary Structures ◽  
Side Chain ◽  
Model Peptides

An intraresidue H-bonding motif in selenocysteine and cysteine, revealed by gas phase laser spectroscopy and quantum chemistry calculations

2020 ◽  
Vol 22 (36) ◽  
pp. 20409-20420 ◽  
Author(s):  
Gildas Goldsztejn ◽  
Venkateswara Rao Mundlapati ◽  
Jérémy Donon ◽  
Benjamin Tardivel ◽  
Eric Gloaguen ◽  
...  
Keyword(s):  
Quantum Chemistry ◽  
Gas Phase ◽  
Laser Spectroscopy ◽  
Side Chain ◽  
Quantum Chemistry Calculations ◽  
Bonding Properties

Models of protein chains containing a seleno-cysteine (Sec) residue have been investigated by gas phase laser spectroscopy in order to document the effect of the H-bonding properties of the SeH group in the folding of the Sec side chain, by comparison with recent data on Ser- and Cys-containing sequences.

scholarly journals The role of flexibility and molecular shape in the crystallization of proteins by surface mutagenesis

2015 ◽  
Vol 71 (2) ◽  
pp. 157-162 ◽  
Author(s):  
Yancho D. Devedjiev
Keyword(s):  
Protein Crystallization ◽  
Protein Structures ◽  
Physicochemical Characteristics ◽  
Molecular Shape ◽  
Side Chain ◽  
Static Disorder ◽  
Relative Contribution ◽  
Crystal Contacts ◽  
Essential Prerequisite

Proteins are dynamic systems and interact with their environment. The analysis of crystal contacts in the most accurately determined protein structures (d< 1.5 Å) reveals that in contrast to current views, static disorder and high side-chain entropy are common in the crystal contact area. These observations challenge the validity of the theory that presumes that the occurrence of well ordered patches of side chains at the surface is an essential prerequisite for a successful crystallization event. The present paper provides evidence in support of the approach for understanding protein crystallization as a process dependent on multiple factors, each with its relative contribution, rather than a phenomenon driven by a few dominant physicochemical characteristics. The role of the molecular shape as a factor in the crystallization of proteins by surface mutagenesis is discussed.

Role of side-chain interactions on the formation ofα-helices in model peptides

2015 ◽  
Vol 91 (3) ◽  
Author(s):  
Farbod Mahmoudinobar ◽  
Cristiano L. Dias ◽  
Ronen Zangi
Keyword(s):  
Side Chain ◽  
Model Peptides

Gas-phase proton-transport self-catalysed isomerisation of glutamine radical cation: The important role of the side-chain

2007 ◽  
Vol 118 (3) ◽  
pp. 589-595 ◽  
Author(s):  
Adrià Gil ◽  
Sílvia Simon ◽  
Mariona Sodupe ◽  
Juan Bertran
Keyword(s):  
Gas Phase ◽  
Radical Cation ◽  
Proton Transport ◽  
Side Chain

Gas Phase Formation of a 310-Helix in a Three-Residue Peptide Chain:  Role of Side Chain-Backbone Interactions as Evidenced by IR−UV Double Resonance Experiments

2005 ◽  
Vol 127 (34) ◽  
pp. 11900-11901 ◽  
Author(s):  
Wutharath Chin ◽  
François Piuzzi ◽  
Jean-Pierre Dognon ◽  
Iliana Dimicoli ◽  
Benjamin Tardivel ◽  
...  
Keyword(s):  
Gas Phase ◽  
Phase Formation ◽  
Double Resonance ◽  
Peptide Chain ◽  
Side Chain ◽  
310 Helix
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