scholarly journals A charge polarization model for the metal-specific activity of superoxide dismutases

2018 ◽  
Vol 20 (4) ◽  
pp. 2363-2372
Author(s):  
Anna Barwinska-Sendra ◽  
Arnaud Baslé ◽  
Kevin J. Waldron ◽  
Sun Un
Keyword(s):  
Specific Activity ◽  
Angular Position ◽  
Superoxide Dismutases ◽  
Polarization Model ◽  
Charge Polarization ◽  
A Charge

EPR shows that the angular position of the histidine-171 ligand likely plays an important role in metal-selective activities of Mn/FeSODs.

Photoinduced Homolytic Bond Cleavage of the Central Si–C Bond in Porphyrin Macrocycles Is a Charge Polarization Driven Process

2016 ◽  
Vol 120 (39) ◽  
pp. 7634-7640 ◽  
Author(s):  
Buddhadev Maiti ◽  
Arun K. Manna ◽  
Christopher McCleese ◽  
Tennyson L. Doane ◽  
Sudha Chakrapani ◽  
...  
Keyword(s):  
Bond Cleavage ◽  
Charge Polarization ◽  
A Charge ◽  
Homolytic Bond Cleavage ◽  
Porphyrin Macrocycles

Fine tuning of metal-specific activity in the Mn-like group of cambialistic superoxide dismutases

RSC Advances ◽  
2015 ◽  
Vol 5 (107) ◽  
pp. 87876-87887 ◽  
Author(s):  
Irene Russo Krauss ◽  
Antonello Merlino ◽  
Andrea Pica ◽  
Rosario Rullo ◽  
Alessandra Bertoni ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Streptococcus Mutans ◽  
Specific Activity ◽  
Streptococcus Thermophilus ◽  
Fine Tuning ◽  
Superoxide Dismutases ◽  
X Ray ◽  
Dependent Activity

Metal-dependent activity and X-ray structures of superoxide dismutase (SOD) fromStreptococcus mutansandStreptococcus thermophilussuggest that they are members of the Mn-like group of cambialistic SODs.

Deuterium-exchange Reactions with Substituted Aromatics. IV. The Poisoning Effect of Molecules Containing Nitrogen, Sulphur, or Arsenic

1963 ◽  
Vol 16 (4) ◽  
pp. 549 ◽  
Author(s):  
RA Ashby ◽  
JL Garnett
Keyword(s):  
Heavy Water ◽  
Aromatic Amines ◽  
Adsorption Mechanism ◽  
Specific Activity ◽  
High Specific Activity ◽  
Side Reactions ◽  
Exchange Reactions ◽  
Poisoning Effect ◽  
A Charge ◽  
Catalytic Exchange

The catalytic exchange properties of a number of organic compounds containing nitrogen, sulphur, or arsenic have been studied in the presence of benzene and heavy water. The results confirm a charge-transfer-no-bond adsorption mechanism previously proposed for the deuteration of aromatic polycyclic hydrocarbons. For aromatic nitrogen compounds an increase in ionization potential of substrate leads to an increase in deuterium incorporation and a decrease in catalyst poisoning. Some aromatic amines deuterate faster than expected by theory and this is attributed to rapid exchange of the amino hydrogens in heavy water with a consequential increase in D-H ratio at the catalyst; surface. Sulphur and arsenic, even in their saturated valency states, extensively poison benzene exchange as does triethylamine. p-Benzoquinone, 2,6-dichloroquinone, and NN-dimethyl benzylamine exhibit catalytic side reactions which poison benzene exchange. With tritium oxide, the technique is suitable for the synthesis of tritiated aromatic amines and heterocycles to high specific activity.

The Morphology of the Rat Kidney Following Folic Acid Administration

1970 ◽  
Vol 28 ◽  
pp. 200-201
Author(s):  
Aline Byrnes ◽  
Elsa E. Ramos ◽  
Minoru Suzuki ◽  
E.D. Mayfield
Keyword(s):  
Folic Acid ◽  
De Novo ◽  
Specific Activity ◽  
Rat Kidney ◽  
Present Report ◽  
Intracellular Localization ◽  
Male Rats ◽  
Renal Hypertrophy ◽  
Electron Microscopic ◽  
Biochemical Alterations

Renal hypertrophy was induced in 100 g male rats by the injection of 250 mg folic acid (FA) dissolved in 0.3 M NaHCO3/kg body weight (i.v.). Preliminary studies of the biochemical alterations in ribonucleic acid (RNA) metabolism of the renal tissue have been reported recently (1). They are: RNA content and concentration, orotic acid-c14 incorporation into RNA and acid soluble nucleotide pool, intracellular localization of the newly synthesized RNA, and the specific activity of enzymes of the de novo pyrimidine biosynthesis pathway. The present report describes the light and electron microscopic observations in these animals. For light microscopy, kidney slices were fixed in formalin, embedded, sectioned, and stained with H & E and PAS.

Four cytosolic-type CuZn-superoxide dismutases in germinating seeds of Pinus sylvestris

1994 ◽  
Vol 92 (3) ◽  
pp. 443-450 ◽  
Author(s):  
Steffen Streller ◽  
Stanislaw Karpinski ◽  
Jan-Erik Hallgren ◽  
Gunnar Wingsle
Keyword(s):  
Pinus Sylvestris ◽  
Superoxide Dismutases ◽  
Germinating Seeds

Assays for Phospholipid-Dependent Formation of Thrombin and Xa: A Potential Method for Quantifying Lupus Anticoagulant Activity

1991 ◽  
Vol 66 (04) ◽  
pp. 453-458 ◽  
Author(s):  
John T Brandt
Keyword(s):  
Specific Activity ◽  
Anticoagulant Activity ◽  
Factor Xa ◽  
Clinical Importance ◽  
Potential Method ◽  
Quantitative Expression ◽  
Increased Risk ◽  
Apparent Association

SummaryLupus anticoagulants (LAs) are antibodies which interfere with phospholipid-dependent procoagulant reactions. Their clinical importance is due to their apparent association with an increased risk of thrombo-embolic disease. To date there have been few assays for quantifying the specific activity of these antibodies in vitro and this has hampered attempts to purify and characterize these antibodies. Methods for determining phospholipid-dependent generation of thrombin and factor Xa are described. Isolated IgG fractions from 7 of 9 patients with LAs were found to reproducibly inhibit enzyme generation in these assay systems, permitting quantitative expression of inhibitor activity. Different patterns of inhibitory activity, based on the relative inhibition of thrombin and factor Xa generation, were found, further substantiating the known heterogeneity of these antibodies. These systems may prove helpful in further purification and characterization of LAs.

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