Divalent ions are potential permeating blockers of the non-selective NaK ion channel: combined QM and MD based investigations

2017 ◽  
Vol 19 (40) ◽  
pp. 27611-27622 ◽  
Author(s):  
Biswajit Sadhu ◽  
Mahesh Sundararajan ◽  
Tusar Bandyopadhyay
Keyword(s):  
Ion Channel ◽  
Metal Ions ◽  
Energy Barrier ◽  
Divalent Metal ◽  
Hydration Energy ◽  
Divalent Metal Ions ◽  
Divalent Ions ◽  
Site Selectivity

The interplay between the hydration energy barrier and optimum site-selectivity controls the permeation and blocking features of divalent metal ions.

Divalent metal ions modulated strong frustrated M(ii)–Fe(iii)3O (M = Fe, Mn, Mg) chains with metamagnetism only in a mixed valence iron complex

2015 ◽  
Vol 51 (83) ◽  
pp. 15336-15339 ◽  
Author(s):  
Qi-Long Wu ◽  
Song-De Han ◽  
Qing-Lun Wang ◽  
Jiong-Peng Zhao ◽  
Feng Ma ◽  
...  
Keyword(s):  
Metal Ions ◽  
Mixed Valence ◽  
Magnetic Behaviour ◽  
Iron Complex ◽  
Divalent Metal ◽  
Heterometallic Complexes ◽  
Divalent Metal Ions ◽  
Divalent Ions ◽  
Mixed Valence Complex

Using divalent ions to link the frustrated Fe(iii)3O units two isostructural chains were generated with distinct magnetic behaviour: frustrations and metamagnetism in mixed valence complex, but magnetic frustrations in heterometallic complexes.

EFFECT OF ACETATE, CITRATE, AND DIVALENT METAL IONS ON UTILIZATION OF SODIUM CASEINATE BY LACTIC STREPTOCOCCI

1957 ◽  
Vol 3 (3) ◽  
pp. 411-417 ◽  
Author(s):  
I. J. McDonald
Keyword(s):  
Metal Ions ◽  
Nitrogen Source ◽  
Sodium Acetate ◽  
Sodium Citrate ◽  
Sodium Caseinate ◽  
Divalent Metal ◽  
Ethylene Diamine ◽  
Divalent Metal Ions ◽  
Divalent Ions ◽  
Diamine Tetraacetate

Growth of caseinate utilizing lactic streptococci in media with sodium caseinate as the nitrogen source was retarded by sodium acetate (40 mg./ml.) and by sodium citrate (10 mg./ml.). The inhibition caused by citrate was relieved by calcium or magnesium while that caused by acetate was relieved by calcium. In media with acid hydrolyzed casein as the nitrogen source, growth was inhibited in the presence of sodium citrate (10 mg./ml.) or disodium ethylene diamine tetraacetate (0.004 mg./ml.) but this inhibition was overcome by the addition of either calcium or magnesium. It appears, therefore, that these divalent ions were not required merely for activation of proteases produced by the organisms.

scholarly journals The permeability of endplate channels to monovalent and divalent metal cations.

1980 ◽  
Vol 75 (5) ◽  
pp. 493-510 ◽  
Author(s):  
D J Adams ◽  
T M Dwyer ◽  
B Hille
Keyword(s):  
Metal Ions ◽  
Surface Potential ◽  
Alkali Metals ◽  
External Solution ◽  
Transition Metal Ions ◽  
Divalent Metal ◽  
Divalent Metal Ions ◽  
Divalent Ions ◽  
Apparent Permeability ◽  
Negative Surface

The relative permeability of endplate channels to monovalent and divalent metal ions was determined from reversal potentials. Thallium is the most permeant ion with a permeability ratio relative to Na+ of 2.5. The selectivity among alkali metals is weak with a sequence, Cs+ greater than Rb+ greater than K+ greater than Na+ greater than Li+, and permeability ratios of 1.4, 1.3, 1.1, 1.0, and 0.9. The selectivity among divalent ions is also weak, with a sequence for alkaline earths of Mg++ greater than Ca++ greater than Ba++ greater than Sr++. The transition metal ions Mn++, Co++, Ni++, Zn++, and Cd++ are also permeant. Permeability ratios for divalent ions decreased as the concentration of divalent ion was increased in a manner consistent with the negative surface potential theory of Lewis (1979 J. Physiol. (Lond.). 286: 417--445). With 20 mM XCl2 and 85.5 mM glucosamine.HCl in the external solution, the apparent permeability ratios for the alkaline earth cations (X++) are in the range 0.18--0.25. Alkali metal ions see the endplate channel as a water-filled, neutral pore without high-field-strength sites inside. Their permeability sequence is the same as their aqueous mobility sequence. Divalent ions, however, have a permeability sequence almost opposite from their mobility sequence and must experience some interaction with groups in the channel. In addition, the concentrations of monovalent and divalent ions are increased near the channel mouth by a weak negative surface potential.

Interaction of divalent metal ions with the NADP+-malic enzyme from maize leaves

1991 ◽  
Vol 81 (4) ◽  
pp. 462-466 ◽  
Author(s):  
Maria Fabiana Drincovich ◽  
Alberto A. Iglesias ◽  
Carlos S. Andreo
Keyword(s):  
Metal Ions ◽  
Malic Enzyme ◽  
Divalent Metal ◽  
Divalent Metal Ions ◽  
Maize Leaves

scholarly journals Regulation of divalent metal ions to the aggregation and membrane damage of human islet amyloid polypeptide oligomers

RSC Advances ◽  
2021 ◽  
Vol 11 (21) ◽  
pp. 12815-12825
Author(s):  
Yajie Wang ◽  
Feihong Meng ◽  
Tong Lu ◽  
Chunyun Wang ◽  
Fei Li
Keyword(s):  
Metal Ions ◽  
Metal Binding ◽  
Membrane Damage ◽  
Islet Amyloid Polypeptide ◽  
Divalent Metal ◽  
Human Islet ◽  
Divalent Metal Ions ◽  
Islet Amyloid ◽  
Induced Membrane ◽  
Human Islet Amyloid Polypeptide

Their is a counteraction between a decrease in the disruptive ability of metal-associated oligomer species and an increase in the quantity of oligomers promoted by the metal binding in the activity of hIAPP induced membrane damage.

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