Role of intrinsic hydrogen bonds in the assembly of perylene imide derivatives in solution and at the liquid–solid interface

2017 ◽  
Vol 19 (34) ◽  
pp. 23007-23014 ◽  
Author(s):  
Zongxia Guo ◽  
Kun Wang ◽  
Ping Yu ◽  
Shengyue Zhang ◽  
Kai Sun ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Hydrogen Bonds ◽  
Bond Formation ◽  
Supramolecular Assembly ◽  
Hydrogen Bond Formation ◽  
Solid Interface ◽  
The Impact

The impact of hydrogen bond formation on the supramolecular assembly of two perylene imide-based derivatives was systematically investigated.

Role of geometrical prodan structures in the determination of possible centers of hydrogen bond formation

2008 ◽  
Vol 51 (1) ◽  
pp. 10-17 ◽  
Author(s):  
O. M. Zharkova ◽  
Yu. P. Morozova ◽  
A. A. Lukashevskaya ◽  
V. Ya. Artyukhov ◽  
B. V. Korolev
Keyword(s):  
Hydrogen Bond ◽  
Bond Formation ◽  
Hydrogen Bond Formation

pH-dependent fusion of didodecyl phosphate vesicles: role of hydrogen-bond formation and membrane fluidity

1988 ◽  
Vol 92 (15) ◽  
pp. 4416-4420 ◽  
Author(s):  
Leo A. M. Rupert ◽  
Jan F. L. Van Breemen ◽  
Dick Hoekstra ◽  
Jan B. F. N. Engberts
Keyword(s):  
Hydrogen Bond ◽  
Membrane Fluidity ◽  
Bond Formation ◽  
Hydrogen Bond Formation ◽  
Ph Dependent

1H -NMRInvestigations on the Hydrogen Bond Formation between the Tranquilizers Diazepam and Nitrazepam and Some Nucleobases

1978 ◽  
Vol 33 (11-12) ◽  
pp. 870-875 ◽  
Author(s):  
Hans-Helmut Paul ◽  
Helmut Sapper ◽  
Wolfgang Lohmann
Keyword(s):  
Hydrogen Bond ◽  
Hydrogen Bonds ◽  
Binding Sites ◽  
Spectroscopic Data ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Bond Formation ◽  
Resonance Spectroscopy ◽  
Hydrogen Bond Formation ◽  
Dimer Model

The formation of hydrogen bonds between the minor tranquilizers diazepam and nitrazepam and a few nucleobases was studied in deuterochloroform solution by means of proton magnetic resonance spectroscopy. The thermodynamic and spectroscopic data of the associations were evaluated on the basis of a dimer model, using the concentration dependent shifts of the protons involved in hydrogen bonds. The interactions of nitrazepam (ΔH0= -10 to -21 k J/mol; ΔG250 - 0.2 to -7.4 kJ/mol) were found to be stronger than those of diazepam (ΔH0 = - 10 to - 13 kJ/mol; ΔG250 = 6.0 to 6.4 k j/mol). The various binding sites of the benzodiazepines for hydrogen bonds are discussed.

scholarly journals Polarisable Hydrogen Bond Formation and Ionic Interactions in Model Phospholipid Polar Head Molecules

1973 ◽  
Vol 28 (5-6) ◽  
pp. 323-330 ◽  
Author(s):  
Georg Papakostidis ◽  
Georg Zundel
Keyword(s):  
Hydrogen Bond ◽  
Hydrogen Bonds ◽  
Phosphoric Acid ◽  
Bond Formation ◽  
Ion Pairs ◽  
Water Soluble ◽  
Ionic Interactions ◽  
Hydrogen Bond Formation ◽  
Continuous Absorption ◽  
Phosphate Groups

The serine phosphoric acid P-methylester (SPM) and the ethanol-amine phosphoric acid P-methylester (EPM) were synthesized as water soluble models for the functional groups of the corresponding phospholipids. Investigations were made of the aqueous solutions of these molecules as a function of deprotonation and protonation. An intramolecular, easily polarisable hydrogen bond occurs in the zwitterion of the SPM. The solutions of different salts of SPM were studied as well as the influence of counter ion pairs. Counterion pairs hardly influence these bonds. At about 50% deprotonation extremely easily polarisable intermolecular bonds form. At about 100% deprotonation of the zwitterion the hydrogen bonds observed are affected by the presence of CO2. The above is indicated by changes of the bands of the carboxylic and phosphate groups, and in particular by a continuous absorption in the infrared spectrum. During protonation of the EPM easily polarisable intermolecular POH+ ... OP hydrogen bonds form at first, but as protonation increases the solutions become acidic, that is, H5O2+ groupings form.

The impact of accessible surface on hydrogen bond formation

CrystEngComm ◽  
2010 ◽  
Vol 12 (8) ◽  
pp. 2485 ◽  
Author(s):  
Peter A. Wood ◽  
Peter T. A. Galek
Keyword(s):  
Hydrogen Bond ◽  
Bond Formation ◽  
Hydrogen Bond Formation ◽  
Accessible Surface ◽  
The Impact

scholarly journals Microscopic Structural Features of Water in Aqueous-Reline Mixture of Varying Composition

2020 ◽  
Author(s):  
Soham Sarkar ◽  
Atanu Maity ◽  
Rajarshi Chakrabarti
Keyword(s):  
Hydrogen Bond ◽  
Hydrogen Bonds ◽  
Choline Chloride ◽  
Bond Formation ◽  
Orientational Order ◽  
Water Structure ◽  
Structural Features ◽  
Water Molecules ◽  
Hydrogen Bond Formation ◽  
Hydrogen Bonded

Reline, a mixture of urea and choline chloride in 2:1 molar ratio, is one of the most frequently used deep eutectic solvents. Pure reline and its aqueous solution have large scale industrial use. Owing to the presence of active hydrogen bond formation sites, urea and choline cation can disrupt the hydrogen-bonded network in water. However, a quantitative understanding of the microscopic structural features of water in the presence of reline is still lacking. We use extensive all-atom molecular dynamics simulations to elucidate the effect of the gradual addition of co-solvents on microscopic arrangements of water molecules. We consider four aqueous solutions of reline, between the wt% 26.3 to 91.4. A disruption of the local hydrogen-bonded water structure is observed on inclusion of urea and choline chloride. The extent of deviation of water structure from tetrahedrality is quantified using the orientational order parameter. Our analyses show a monotonic increase in structural disorder as the co-solvents are added. Increment in the values are observed when highly electro-negative hetero-atoms like Nitrogen, Oxygen of urea and choline cations are counted as the partners of the central water molecules. Further insights are drawn from the characterization of the hydrogen-bonded network of the water and we observe gradual rupturing of water-water hydrogen bonds and its subsequent replacement by the water-urea hydrogen bonds. A negligible contribution from the hydrogen bonds between water and bulky choline cation has also been found. Considering all the constituents as the hydrogen bond partner we calculate the possibility of successful hydrogen bond formation with a central water molecule. This gives a clear picture of the underlying mechanism of water replacement by urea.

scholarly journals A frequent, GxxxG-mediated, transmembrane association motif is optimized for the formation of interhelical Cα–H hydrogen bonds

2014 ◽  
Vol 111 (10) ◽  
pp. E888-E895 ◽  
Author(s):  
Benjamin K. Mueller ◽  
Sabareesh Subramaniam ◽  
Alessandro Senes
Keyword(s):  
Hydrogen Bond ◽  
Hydrogen Bonds ◽  
Bond Formation ◽  
Geometric Analysis ◽  
Prediction Method ◽  
Causal Link ◽  
Conformational Space ◽  
Hydrogen Bond Formation ◽  
Frequent Motif ◽  
Single Region

Carbon hydrogen bonds between Cα–H donors and carbonyl acceptors are frequently observed between transmembrane helices (Cα–H···O=C). Networks of these interactions occur often at helix−helix interfaces mediated by GxxxG and similar patterns. Cα–H hydrogen bonds have been hypothesized to be important in membrane protein folding and association, but evidence that they are major determinants of helix association is still lacking. Here we present a comprehensive geometric analysis of homodimeric helices that demonstrates the existence of a single region in conformational space with high propensity for Cα–H···O=C hydrogen bond formation. This region corresponds to the most frequent motif for parallel dimers, GASright, whose best-known example is glycophorin A. The finding suggests a causal link between the high frequency of occurrence of GASright and its propensity for carbon hydrogen bond formation. Investigation of the sequence dependency of the motif determined that Gly residues are required at specific positions where only Gly can act as a donor with its “side chain” Hα. Gly also reduces the steric barrier for non-Gly amino acids at other positions to act as Cα donors, promoting the formation of cooperative hydrogen bonding networks. These findings offer a structural rationale for the occurrence of GxxxG patterns at the GASright interface. The analysis identified the conformational space and the sequence requirement of Cα–H···O=C mediated motifs; we took advantage of these results to develop a structural prediction method. The resulting program, CATM, predicts ab initio the known high-resolution structures of homodimeric GASright motifs at near-atomic level.

Large perturbations of long-range nJ(1H,1H) and nJ(1H,19F) by the intramolecular hydrogen bonds in 2-mercaptobenzaldehyde, salicylaldehyde, and some derivatives. Reference structures for intramolecular hydrogen bonds

1993 ◽  
Vol 71 (7) ◽  
pp. 960-967 ◽  
Author(s):  
Ted Schaefer ◽  
Rudy Sebastian ◽  
David M. McKinnon ◽  
Perry W. Spevack ◽  
Kerry J. Cox ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Hydrogen Bonds ◽  
Long Range ◽  
Bond Formation ◽  
Coupling Constants ◽  
Hydrogen Bond Formation ◽  
Intramolecular Hydrogen Bonds ◽  
Large Perturbation ◽  
Intramolecular Hydrogen ◽  
Hydrogen Bonded

Precise 1H nuclear magnetic resonance spectral parameters are reported for salicyladehyde and its 3-fluoro and 5-fluoro derivatives in nonpolar solutions. Such data are also given for the 2-mercapto, 2-methylthio, and 2-methoxy derivatives of benzaldehyde. Comparison of the long-range coupling constants in the various compounds and their conformers shows a large perturbation of their magnitudes by hydrogen bond formation. For the salicylaldehyde system, the perturbation is particularly large for couplings involving the aldehyde proton and protons or fluorine nuclei placed ortho to the hydroxyl group. For example, 5Jt (F, CHO) is reduced by about 50%. The perturbation, as expected, is much smaller for coupling constants of nuclei remote from the site of the hydrogen bond. In 2-mercaptobenzaldehyde the long-range coupling constants are also sensitive to hydrogen bond formation, those involving the sulfhydryl proton markedly so compared to the hydroxyl proton in salicylaldehyde. The strength of the [Formula: see text] bond is discussed. It is argued that the reference conformer for the mercapto compound in such a discussion is less easily defined than for salicylaldehyde because [Formula: see text] are similar to [Formula: see text] energies. The experimental data for the CCl4 solutions imply a free energy of formation of the [Formula: see text] bond of 4.8(5) kJ/mol at 300 K. Molecular orbital computations on the four planar conformers of each salicylaldehyde and 2-mercaptobenzaldehyde with the 6-31 G**(5D) basis are reported. For salicylaldehyde, the [Formula: see text] arrangement is taken as the reference conformer, with a computed energy of 25.7 kJ/mol relative to the hydrogen-bonded structure. For 2-mercaptobenzaldehyde, the [Formula: see text] and [Formula: see text] conformers are calculated to be isoenergetic, at 5.1 kJ/mol relative to the hydrogen-bonded conformer. Hence either arrangement serves as a reference structure in computations of the strength of the hydrogen bond. The computations are consistent with the experimental results for solutions of the molecules under discussion. An appendix gives the computed geometries of the eight planar conformers, as well as some atomic charges, allowing a rationalization of the relative energies of the conformers.

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