Self-assembled core–polyethylene glycol–lipid shell nanoparticles demonstrate high stability in shear flow

2017 ◽  
Vol 19 (20) ◽  
pp. 13294-13306 ◽  
Author(s):  
Zhiqiang Shen ◽  
Huilin Ye ◽  
Martin Kröger ◽  
Ying Li

Core–polyethylene glycol–lipid shell (CPLS) nanoparticles demonstrate higher stability and less deformation in shear flow, in comparison with lipid vesicles.

2021 ◽  
Author(s):  
Vedagopuram Sreekanth ◽  
Sanjay Pal ◽  
Sandeep Kumar ◽  
Varsha Komalla ◽  
Poonam Yadav ◽  
...  

Herein, we present the engineering of a supramolecular nanomicellar system that is composed of self-assembled units of PEGylated lithocholic acid (LCA)-Docetaxel (DTX) conjugate (LCA-DTX-PEG). We tethered a short polyethylene glycol...


2019 ◽  
Vol 101 ◽  
pp. 448-463 ◽  
Author(s):  
Piyush Kumar Gupta ◽  
Sreenath Pappuru ◽  
Santosh Gupta ◽  
Bamadeb Patra ◽  
Debashis Chakraborty ◽  
...  

Materials ◽  
2018 ◽  
Vol 11 (10) ◽  
pp. 1787 ◽  
Author(s):  
Mengda Xu ◽  
Jie Liu ◽  
Xiankui Xu ◽  
Shanhu Liu ◽  
František Peterka ◽  
...  

Silver nanoparticles synthesized with polymers as coating agents is an effective method to overcome their poor stability and aggregation in solution. Silver-polyethylene glycol (Ag-PEG) nanoparticles were synthesized with the thiol-functionalized polyethylene glycol (SH-PEA) as the coating, reducing and stabilizing agent. The UV irradiation time, polymer and silver nitrate concentration for the synthesis were investigated. The concentration of silver nitrate had significant effect on the morphology of Ag-PEG nanoparticles. When increasing the concentration of silver nitrate, SEM and TEM images showed that Ag-PEG nanoparticles changed from Janus to multi-core shell structure. Meanwhile, pure silver particles in the two hybrid nanoparticles presented spherical shape and had the similar size of 15 nm. The antibacterial activities and cytotoxicity of the two structural Ag-PEG nanoparticles were investigated to understand colloid morphology effect on the properties of AgNPs. The results of antibacterial activities showed that the two structural Ag-PEG nanoparticles exhibited strong antibacterial activities against Staphylococcus aureus, Escherichia coli and Bacillus subtilis. The Janus nanoparticles had larger minimal inhibitory concentration (MIC) and minimum bacterial concentration (MBC) values than the multi-core shell counterparts. The results of cytotoxicity showed the Janus Ag-PEG nanoparticles had lower toxicity than the multi-core shell nanoparticles.


2012 ◽  
Author(s):  
Qianqian Geng ◽  
Zhenyi Chen ◽  
Na Chen ◽  
Shupeng Liu ◽  
Chen Qian ◽  
...  

Biomaterials ◽  
2004 ◽  
Vol 25 (18) ◽  
pp. 4297-4308 ◽  
Author(s):  
Cheng-Shu Chaw ◽  
Kar-Wai Chooi ◽  
Xue-Ming Liu ◽  
Cherng-wen Tan ◽  
Lin Wang ◽  
...  

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