Dimerization and conformation-related free energy landscapes of dye-tagged amyloid-β12–28linked to FRET experiments

The free energy landscapes of Aβ-peptide dimer models under different prototype conditions support the hypothesis that the gas-phase action-FRET measurement after electrospray ionization operates under non-equilibrium conditions, with a memory of the solution conditions – even for the dimer of this relatively short peptide.