Continuous purification of active pharmaceutical ingredients utilizing polymer membrane surface wettability

2018 ◽  
Vol 54 (1) ◽  
pp. 70-73 ◽  
Author(s):  
Joseph Imbrogno ◽  
Luke Rogers ◽  
Dale A. Thomas ◽  
Klavs F. Jensen
Keyword(s):  
Phase Separation ◽  
Membrane Surface ◽  
Liquid Extraction ◽  
Polymer Membrane ◽  
Surface Wettability ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Liquid Liquid Extraction

Liquid–liquid extraction followed by dual membrane based phase separation in flow enables fully continuous purification of active pharmaceutical ingredients.

scholarly journals Powerful Concentration of Rhodium in Plating Wastewater Using Homogeneous Liquid–Liquid Extraction (HoLLE) and Study for Scale-up

2017 ◽  
Vol 7 (4) ◽  
pp. 44 ◽  
Author(s):  
Takeshi Kato ◽  
Shotaro Saito ◽  
Shigekatsu Oshite ◽  
Shukuro Igarashi
Keyword(s):  
Phase Separation ◽  
Liquid Phase ◽  
Aqueous Phase ◽  
Scale Up ◽  
Volume Ratio ◽  
Liquid Extraction ◽  
Optimum Conditions ◽  
Homogeneous Liquid ◽  
Liquid Liquid Extraction ◽  
Plating Wastewater

A powerful technique for the concentration of rhodium (Rh) in plating wastewater was developed. The technique entails complexing Rh with 1-(2-pyridylazo)-2-naphthol (PAN) followed by homogeneous liquid–liquid extraction (HoLLE) with Zonyl FSA. The optimum HoLLE conditions were determined as follows: [ethanol]T = 30.0 vol.%, pH = 4.00, and Rh:PAN = 1:5. Under these optimum conditions, 88.1% of Rh was extracted into the sedimented liquid phase. After phase separation, the volume ratio [aqueous phase (Va) /sedimented liquid phase (Vs)] of Va and Vs was 1000 (50 mL → 0.050 mL). We then applied the new method to wastewater generated by the plating industry. The phase separation was satisfactorily achieved when the volume was scaled up to 1000 mL of the actual wastewater; 84.7% of Rh was extracted into the sedimented liquid phase. After phase separation, Va/Vs was 588 (1000 mL - 1.70 mL).

Treatment of real oilfield produced water by liquid-liquid extraction and efficient phase separation in a mixer-settler based on phase inversion

2020 ◽  
pp. 127926
Author(s):  
Ana Caroline Klemz ◽  
Mayra Stéphanie Pascoal Damas ◽  
Silvio Edegar Weschenfelder ◽  
Sergio Yesid Gómez González ◽  
Leonardo dos Santos Pereira ◽  
...  
Keyword(s):  
Phase Separation ◽  
Phase Inversion ◽  
Produced Water ◽  
Liquid Extraction ◽  
Liquid Liquid Extraction ◽  
Oilfield Produced Water

scholarly journals Matrix-Induced Sugaring-Out: A Simple and Rapid Sample Preparation Method for the Determination of Neonicotinoid Pesticides in Honey

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2761 ◽  
Author(s):  
Wenbin Chen ◽  
Siyuan Wu ◽  
Jianing Zhang ◽  
Fengjie Yu ◽  
Jianbo Hou ◽  
...  
Keyword(s):  
Phase Separation ◽  
Sample Preparation ◽  
Preparation Method ◽  
Liquid Extraction ◽  
Subzero Temperature ◽  
Water Mixture ◽  
Sample Preparation Method ◽  
Liquid Liquid Extraction ◽  
Neonicotinoid Pesticides

In the present work, we developed a simple and rapid sample preparation method for the determination of neonicotinoid pesticides in honey based on the matrix-induced sugaring-out. Since there is a high concentration of sugars in the honey matrix, the honey samples were mixed directly with acetonitrile (ACN)-water mixture to trigger the phase separation. Analytes were extracted into the upper ACN phase without additional phase separation agents and injected into the HPLC system for the analysis. Parameters of this matrix-induced sugaring-out method were systematically investigated. The optimal protocol involves 2 g honey mixed with 4 mL ACN-water mixture (v/v, 60:40). In addition, this simple sample preparation method was compared with two other ACN-water-based homogenous liquid-liquid extraction methods, including salting-out assisted liquid-liquid extraction and subzero-temperature assisted liquid-liquid extraction. The present method was fully validated, the obtained limits of detection (LODs) and limits of quantification (LOQs) were from 21 to 27 and 70 to 90 μg/kg, respectively. Average recoveries at three spiked levels were in the range of 91.49% to 97.73%. Precision expressed as relative standard deviations (RSDs) in the inter-day and intra-day analysis were all lower than 5%. Finally, the developed method was applied for the analysis of eight honey samples, results showed that none of the target neonicotinoid residues were detected.

scholarly journals The Crystallization of Active Pharmaceutical Ingredients with Low Melting Points in the Presence of Liquid–Liquid Phase Separation

Crystals ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1326
Author(s):  
Wei Han Lin ◽  
Zai-Qun Yu ◽  
Pui Shan Chow ◽  
Reginald Beng Hee Tan
Keyword(s):  
Phase Separation ◽  
Liquid Phase ◽  
Hydroxypropyl Methylcellulose ◽  
Tween 80 ◽  
Liquid Phase Separation ◽  
Water Mixture ◽  
Active Pharmaceutical Ingredients ◽  
Melting Points ◽  
Pharmaceutical Ingredients ◽  
Liquid Liquid Phase Separation

Liquid–liquid phase separation (LLPS) during the crystallization of active pharmaceutical ingredients (APIs) often causes agglomeration and other quality issues in crystal products; thus, it should be avoided if possible. However, LLPS in the crystallization of APIs with low melting points cannot be circumvented in some cases due to yield considerations. The crystallization of ibuprofen in an ethanol/water mixture was studied to explore methods to reduce agglomeration in the presence of LLPS. It was found that unseeded crystallization produced agglomerates when LLPS took place. The two liquid phases resulting from LLPS underwent LLPS again when they were cooled separately, indicating the dynamic nature of LLPS. Seeding and seed ageing at a low supersaturation were very effective in mitigating agglomeration. The effects of two widely used surfactants, i.e., Tween 80 and hydroxypropyl methylcellulose (HPMC), on LLPS and crystallization were confirmed preliminarily. More work needs to be conducted to explore their usefulness in LLPS handling. The findings and techniques presented in this study may be applicable to the crystallization of other APIs with low melting points.

Liquid-liquid extraction in continuous flow systems without phase separation

1988 ◽  
Vol 60 (21) ◽  
pp. 2354-2357 ◽  
Author(s):  
Francisco. Canete ◽  
Angel. Rios ◽  
M. Dolores. Luque de Castro ◽  
Miguel. Valcarcel
Keyword(s):  
Phase Separation ◽  
Continuous Flow ◽  
Liquid Extraction ◽  
Liquid Liquid Extraction ◽  
Flow Systems
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