Aptamer-modified selenium nanoparticles for dark-field microscopy imaging of nucleolin

2017 ◽  
Vol 53 (97) ◽  
pp. 13047-13050 ◽  
Author(s):  
Meng Li Liu ◽  
Hong Yan Zou ◽  
Chun Mei Li ◽  
Rong Sheng Li ◽  
Cheng Zhi Huang
Keyword(s):  
Light Scattering ◽  
Cancer Cells ◽  
Water Solubility ◽  
Dark Field ◽  
Selenium Nanoparticles ◽  
Microscopy Imaging ◽  
Dark Field Microscopy ◽  
First Time

Selenium nanoparticles with good water solubility and excellent biocompatibility are used for the first time as a light-scattering nanoprobe with aptamer modification to image nucleolin-overexpressing cancer cells through dark-field microscopy.

A galvanic exchange process visualized on single silver nanoparticles via dark-field microscopy imaging

Nanoscale ◽  
2018 ◽  
Vol 10 (26) ◽  
pp. 12805-12812 ◽  
Author(s):  
Jun Zhou ◽  
Tong Yang ◽  
Wei He ◽  
Zi Yu Pan ◽  
Cheng Zhi Huang
Keyword(s):  
Silver Nanoparticles ◽  
Light Scattering ◽  
Reaction Kinetics ◽  
Removal Rate ◽  
Exchange Process ◽  
Dark Field ◽  
Gold Deposition ◽  
Microscopy Imaging ◽  
Dark Field Microscopy ◽  
Kinetics Of

A galvanic exchange (GE) process was visually monitored in real-time using light scattering dark-field microscopy imaging, through which the reaction kinetics of the GE process was visualized and the silver removal rate and gold deposition rate on single nanoparticles were revealed.

Real-time monitoring of oxidative etching on single Ag nanocubes via light-scattering dark-field microscopy imaging

Nanoscale ◽  
2015 ◽  
Vol 7 (37) ◽  
pp. 15209-15213 ◽  
Author(s):  
Yi Wang ◽  
Hong Yan Zou ◽  
Cheng Zhi Huang
Keyword(s):  
Light Scattering ◽  
Real Time ◽  
Dark Field ◽  
Real Time Monitoring ◽  
Microscopy Imaging ◽  
Real Time Mode ◽  
Oxidative Etching ◽  
Dark Field Microscopy

Oxidative etching on single Ag nanocubes was monitored in real-time mode through light-scattering dark-field microscopy imaging.

Analytical methods based on the light-scattering of plasmonic nanoparticles at the single particle level with dark-field microscopy imaging

The Analyst ◽  
2017 ◽  
Vol 142 (2) ◽  
pp. 248-256 ◽  
Author(s):  
Tian Li ◽  
Xi Wu ◽  
Feng Liu ◽  
Na Li
Keyword(s):  
Light Scattering ◽  
Single Particle ◽  
Analytical Methods ◽  
Imaging Technique ◽  
Dark Field ◽  
Plasmonic Nanoparticles ◽  
Microscopy Imaging ◽  
Single Particle Level ◽  
Dark Field Microscopy ◽  
Particle Level

This minireview summarizes analytical methods based on the light-scattering of gold nanoparticles with the dark-field microscopy imaging technique at the single particle level.

Color resolution improvement of the dark-field microscopy imaging of single light scattering plasmonic nanoprobes for microRNA visual detection

Nanoscale ◽  
2017 ◽  
Vol 9 (13) ◽  
pp. 4593-4600 ◽  
Author(s):  
Jun Zhou ◽  
Peng Fei Gao ◽  
Hong Zhi Zhang ◽  
Gang Lei ◽  
Lin Ling Zheng ◽  
...  
Keyword(s):  
Light Scattering ◽  
Visual Detection ◽  
Dark Field ◽  
Microscopy Imaging ◽  
Dark Field Microscopy ◽  
Resolution Improvement

A dark-field light scattering platform for real-time monitoring of the erosion of microparticles by Co2+

The Analyst ◽  
2014 ◽  
Vol 139 (11) ◽  
pp. 2783-2787 ◽  
Author(s):  
Hui Yang ◽  
Yue Liu ◽  
Peng Fei Gao ◽  
Jian Wang ◽  
Cheng Zhi Huang
Keyword(s):  
Light Scattering ◽  
Real Time ◽  
Slight Modification ◽  
Dark Field ◽  
Real Time Monitoring ◽  
Microscopy Imaging ◽  
The Real ◽  
Dark Field Microscopy

Poly(p-phenylenediamine) (PpPD) microparticles were prepared by the reported methods with slight modification, and then used for the real-time monitoring the erosion reaction between PpPD microparticles and Co2+ with a dark-field microscopy imaging (iDFM) technique.

scholarly journals A Novel Approach of Targeted Immunotherapy against Adenocarcinoma Cells with Nanoparticles Modified by CD16 and MUC1 Aptamers

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Lianyuan Yu ◽  
Yan Hu ◽  
Jinhong Duan ◽  
Xian-Da Yang
Keyword(s):  
Nk Cells ◽  
Cancer Cells ◽  
Dark Field ◽  
Negative Control ◽  
Mucin 1 ◽  
Novel Approach ◽  
Adenocarcinoma Cells ◽  
Dark Field Microscopy ◽  
Average Size ◽  
Nk Cytotoxicity

Mucin 1 (MUC1) is a potentially important target of cancer therapy, being a glycoprotein that is overexpressed on cell surface of many types of adenocarcinomas, including breast, ovarian, colon, lung, and prostatic cancers. Several MUC1-targeted drug delivery systems have been developed and reported, but mobilizing natural killer cells (NK) to fight against MUC1-positive tumor has not been attempted. In this study, we introduced a novel amphipathic nanoparticle (NP) for enhancing the NK cytotoxicity to MUC1-positive cancer cells. The amphipathic NP had CD16 and MUC1 aptamers on its surface and was designed to bind with both the CD16-positive NK cells and the MUC1-positive tumor cells and pull the two types of cells close to each other. The fabricated amphipathic NP had an average size of 574 nm. The aptamers’ conjugation with the NP was confirmed by DNA hybridization experiments. Dark-field microscopy revealed that the amphipathic NP could recruit more NK cells to the vicinity of MUC1-positive cancer cells. Additionally, the amphipathic NP significantly enhanced the NK cytotoxicity to MUC1-positive cancer cellsp<0.01, but not that to the MUC1-negative control cells. The results suggest that NK cells may potentially be mobilized to selectively fight against MUC1-positive cancer cells.

Precision improvement in dark-field microscopy imaging by using gold nanoparticles as an internal reference: a combined theoretical and experimental study

Nanoscale ◽  
2016 ◽  
Vol 8 (16) ◽  
pp. 8729-8736 ◽  
Author(s):  
Jun Ma ◽  
Yue Liu ◽  
Peng Fei Gao ◽  
Hong Yan Zou ◽  
Cheng Zhi Huang
Keyword(s):  
Experimental Study ◽  
Gold Nanoparticles ◽  
Measurement Errors ◽  
Dark Field ◽  
Internal Reference ◽  
Microscopy Imaging ◽  
Microscopic Imaging ◽  
Dark Field Microscopy

The internal reference (IR) was introduced to dark-field microscopic imaging (iDFM) technique to reduce the large unavoidable measurement errors, and improved precision of the acquired signals has been obtained.

Observation of time-dependent single-particle light scattering from gold nanorods and nanospheres by using unpolarized dark-field microscopy

2006 ◽  
Author(s):  
Vladimir A. Bogatyrev ◽  
Lev A. Dykman ◽  
Anna V. Alekseeva ◽  
Boris N. Khlebtsov ◽  
Anna P. Novikova ◽  
...  
Keyword(s):  
Light Scattering ◽  
Gold Nanorods ◽  
Single Particle ◽  
Dark Field ◽  
Time Dependent ◽  
Dark Field Microscopy
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