Immobilization of catalytic virus-like particles in a flow reactor

2017 ◽  
Vol 53 (54) ◽  
pp. 7632-7634 ◽  
Author(s):  
A. Liu ◽  
L. Yang ◽  
C. H.-H. Traulsen ◽  
J. J. L. M. Cornelissen
Keyword(s):  
High Efficiency ◽  
Flow Reactor ◽  
Virus Like Particles ◽  
Protein Cages ◽  
Microfluidic Reactor

A functional microfluidic reactor is constructed by the immobilization of gold containing virus-based protein cages that catalyze the reduction of nitro-arenes with high efficiency.

scholarly journals Continuous-Flow Photocatalytic Microfluidic-Reactor for the Treatment of Aqueous Contaminants, Simplicity, and Complexity: A Mini-Review

Symmetry ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1325
Author(s):  
Zhongwei Gao ◽  
Changqing Pan ◽  
Chang-Ho Choi ◽  
Chih-Hung Chang
Keyword(s):  
Continuous Flow ◽  
Lower Energy ◽  
High Efficiency ◽  
Diffusion Length ◽  
Physical Adsorption ◽  
Chemical Oxidation ◽  
Microfluidic Reactor ◽  
Global Issue ◽  
The Individual ◽  
Aqueous Contaminants

Water pollution is a growing global issue; there are many approaches to treating wastewater, including chemical coagulation, physical adsorption, and chemical oxidation. The photocatalysis process has provided a solution for removing pollutants from wastewater, where the pair of the photoelectron and hole works through an asymmetric way to degrade the contaminants under UV irradiation. This method offers an alternative route for treating the pollutant with a lower energy cost, high efficiency, and fewer byproducts. A continuous-flow microfluidic reactor has a channel size from tens to thousands of micrometers, providing uniform irradiation and short diffusion length. It can enhance the conversion efficiency of photocatalysis due to the simple spatial symmetry inside the microreactor channel and among the individual channels. In addition, the bandgap of TiO2, ZnO, or other photocatalyst nanoparticles with symmetric crystal structure can be modified through doping or embedding. In this mini-review, a review of the reported continuous-flow photocatalytic microfluidic reactor is discussed from the perspective of both microreactor design and material engineering.

scholarly journals Efficient trans-Encapsidation of Hepatitis C Virus RNAs into Infectious Virus-Like Particles

2008 ◽  
Vol 82 (14) ◽  
pp. 7034-7046 ◽  
Author(s):  
Eike Steinmann ◽  
Christiane Brohm ◽  
Stephanie Kallis ◽  
Ralf Bartenschlager ◽  
Thomas Pietschmann
Keyword(s):  
Tissue Culture ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
High Efficiency ◽  
Infectious Virus ◽  
Buoyant Density ◽  
Target Cells ◽  
Packaging Cell Line ◽  
Virus Like Particles ◽  
Rna Elements

ABSTRACT Recently, complete replication of hepatitis C virus (HCV) in tissue culture was established using the JFH1 isolate. To analyze determinants of HCV genome packaging and virion assembly, we developed a system that supports particle production based on trans-packaging of subgenomic viral RNAs. Using JFH1 helper viruses, we show that subgenomic JFH1 replicons lacking the entire core to NS2 coding region are efficiently encapsidated into infectious virus-like particles. Similarly, chimeric helper viruses with heterologous structural proteins trans-package subgenomic JFH1 replicons. Like authentic cell culture-produced HCV (HCVcc) particles, these trans-complemented HCV particles (HCVTCP) penetrate target cells in a CD81 receptor-dependent fashion. Since HCVTCP production was limited by competition between the helper and subgenomic RNA and to avoid contamination of HCVTCP stocks with helper viruses, we created HCV packaging cells. These cells encapsidate various HCV replicons with high efficiency, reaching infectivity titers up to 106 tissue culture infectious doses 50 per milliliter. The produced particles display a buoyant density comparable to HCVcc particles and can be propagated in the packaging cell line but support only a single-round infection in naïve cells. Together, this work demonstrates that subgenomic HCV replicons are assembly competent, thus excluding cis-acting RNA elements in the core-to-NS2 genomic region essential for RNA packaging. The experimental system described here should be helpful to decipher the mechanisms of HCV assembly and to identify RNA elements and viral proteins involved in particle formation. Similar to other vector systems of plus-strand RNA viruses, HCVTCP may prove valuable for gene delivery or vaccination approaches.

scholarly journals Development and numerical modelling of a novel UV/H2O2 rotating flow reactor for water treatment

2021 ◽  
Author(s):  
Minghan Luo ◽  
Wenjie Xu ◽  
Taeseop Jeong
Keyword(s):  
Numerical Modelling ◽  
Uv Irradiation ◽  
High Efficiency ◽  
Flow Reactor ◽  
Reaction Rates ◽  
Photochemical Reactions ◽  
Rotating Flow ◽  
Flow Mode ◽  
Oh Radicals ◽  
Wide Range

Abstract The ultraviolet photochemical degradation process is widely applied in wastewater treatment due to its low cost, high efficiency and sustainability. In this study, a novel rotating flow reactor was developed for UV-initiated photochemical reactions. The reactor was run in a continuous flow mode, and the tangential installation of the inlet and outlet on the annular reactor improved reaction rates. Numerical modelling, which combined solute transport, radiation transfer and photochemical kinetic degradation processes, was conducted to evaluate improvement compared to current reactor designs. Methylene Blue (MB) decomposition efficiency from the modelling results and the experimental data agreed well with each other. The model results showed that a rotational motion of fluid was well developed inside the designed reactor for a wide range of inflow rates; the generation of ·OH radicals significantly depended on UV irradiation dose, and thus the degradation ratio of MB showed a strong correlation with the UV irradiation distribution. In addition, the comprehensive numerical modelling showed promising potential for the simulation of UV/H2O2 processes in rotating flow reactors.

scholarly journals Ring-Opening of Epoxides with Amines for Synthesis of β-Amino Alcohols in a Continuous-Flow Biocatalysis System

Catalysts ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1419
Author(s):  
Li-Hua Du ◽  
Miao Xue ◽  
Meng-Jie Yang ◽  
Yue Pan ◽  
Ling-Yan Zheng ◽  
...  
Keyword(s):  
Continuous Flow ◽  
High Efficiency ◽  
Flow Reactor ◽  
Low Cost ◽  
Amino Alcohols ◽  
Thermomyces Lanuginosus ◽  
Synthetic Approach ◽  
Promising Alternative ◽  
Alcohol Synthesis ◽  
Ring Opening Of Epoxides

An efficient method for the preparation of β-amino alcohols catalyzed by lipase TL IM from Thermomyces lanuginosus in a continuous-flow reactor was developed. The eco-friendly biocatalyst combined with continuous-flow reaction technology displayed high efficiency in the synthesis of β-amino alcohols. The benign reaction conditions (35 °C) and short residence time (20 min), together with the use of low cost and readily available starting materials, make this synthetic approach a promising alternative to current β-amino alcohol synthesis.

scholarly journals A catalytic chiral gel microfluidic reactor assembled via dynamic covalent chemistry

2015 ◽  
Vol 6 (4) ◽  
pp. 2292-2296 ◽  
Author(s):  
Haoliang Liu ◽  
Juan Feng ◽  
Jianyong Zhang ◽  
Philip W. Miller ◽  
Liuping Chen ◽  
...  
Keyword(s):  
Flow Reactor ◽  
Dynamic Covalent Chemistry ◽  
Microfluidic Reactor ◽  
Microfluidic Flow ◽  
Asymmetric Catalyst

A novel dynamic covalent gel strategy is reported to immobilize an asymmetric catalyst within the channels of a microfluidic flow reactor.

scholarly journals An Optimized Cr(VI)-Removal System Using Sn-based Reducing Adsorbents

Water ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2477 ◽  
Author(s):  
George Papadopoulos ◽  
Theopoula Asimakidou ◽  
Dimitrios Karfaridis ◽  
Ioannis Kellartzis ◽  
George Vourlias ◽  
...  
Keyword(s):  
Drinking Water ◽  
High Efficiency ◽  
Flow Reactor ◽  
Synthesis Method ◽  
Free Water ◽  
Complete Removal ◽  
Polluted Water ◽  
Tin Chloride ◽  
Point Of Use ◽  
Test Operation

Despite significant risks to human health due to elevated Cr(VI) concentrations in drinking water, a selective adsorbent capable of purifying water before consumption is still not commercially available. This work introduces an integrated household water filtration setup, for point-of-use applications, loaded with a tin-based Cr(VI)-oriented adsorbent that was tested under various contact times, pH values and Cr(VI) concentrations. The adsorbent comprises a chloride-substituted stannous oxy-hydroxide with a structure resembling that of the mineral abhurite. It demonstrated high reducing capacity that triggered the formation of insoluble Cr(III) hydroxides and the complete removal of Cr(VI) in considerably high volumes of polluted water. Test operation of the filtration system verified its ability to produce Cr(VI)-free water in compliance with the impending drinking water regulation, even for extreme initial concentrations (1000 μg/L). Apart from its high efficiency, the potential of the studied material is enhanced by its minimal-cost synthesis method carried out in a continuous-flow reactor by tin chloride precipitation under acidic conditions.

ChemInform Abstract: High-Efficiency Aminocarbonylation by Introducing CO to a Pressurized Continuous Flow Reactor.

ChemInform ◽  
2008 ◽  
Vol 39 (34) ◽  
Author(s):  
Csaba Csajagi ◽  
Bernadett Borcsek ◽  
Krisztian Niesz ◽  
Ildiko Kovacs ◽  
Zsolt Szekelyhidi ◽  
...  
Keyword(s):  
Continuous Flow ◽  
High Efficiency ◽  
Flow Reactor ◽  
Continuous Flow Reactor
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