scholarly journals Diastereoselective synthesis of novel heterocyclic scaffolds through tandem Petasis 3-component/intramolecular Diels–Alder and ROM–RCM reactions

2017 ◽  
Vol 53 (68) ◽  
pp. 9410-9413 ◽  
Author(s):  
Mette Ishoey ◽  
Rico G. Petersen ◽  
Michael Å. Petersen ◽  
Peng Wu ◽  
Mads H. Clausen ◽  
...  
Keyword(s):  
Heterocyclic Compound ◽  
Diels Alder ◽  
Diastereoselective Synthesis ◽  
Compound Libraries

Complexity-generating tandem Petasis 3-component/intramolecular Diels–Alder and ROM–RCM reactions for the diastereoselective synthesis of sp3-rich heterocyclic compound libraries are presented.

Synthetic Strategies to Access Heteroatomic Spirocentres Embedded in Natural Products

Synthesis ◽  
2021 ◽  
Author(s):  
Michael P. Badart ◽  
Bill C. Hawkins
Keyword(s):  
Natural Products ◽  
Heterocyclic Compound ◽  
Chemical Space ◽  
Three Dimensional ◽  
Coupling Reactions ◽  
Conjugate Additions ◽  
Biological Targets ◽  
Compound Libraries ◽  
The Common ◽  
Significant Attention

AbstractThe spirocyclic motif is abundant in natural products and provides an ideal three-dimensional template to interact with biological targets. With significant attention historically expended on the synthesis of flat-heterocyclic compound libraries, methods to access the less-explored three-dimensional medicinal-chemical space will continue to increase in demand. Herein, we highlight by reaction class the common strategies used to construct the spirocyclic centres embedded in a series of well-studied natural products.1 Introduction2 Cycloadditions3 Palladium-Catalysed Coupling Reactions4 Conjugate Additions5 Imines, Aminals, and Hemiaminal Ethers6 Mannich-Type Reactions7 Oxidative Dearomatisation8 Alkylation9 Organometallic Additions10 Conclusions

Uncatalyzed diastereoselective synthesis of alkyliminofurochromone-derived benzylmalononitriles via a three-component cascade reaction: competition between Diels–Alder cycloaddition and Michael addition

2021 ◽  
Author(s):  
Mohammad Bagher Teimouri ◽  
Zahra Mokhtare ◽  
Hamid Reza Khavasi
Keyword(s):  
Michael Addition ◽  
Heterocyclic Ring ◽  
Cascade Reaction ◽  
Diels Alder ◽  
Chemical Bonds ◽  
Diastereoselective Synthesis ◽  
Atom Economy ◽  
One Pot

Three new chemical bonds and three stereogenic centres and one heterocyclic ring were assembled stereoselectively in a convenient high atom-economy one-pot operation.

scholarly journals Diastereoselective synthesis of novel spiro indanone fused pyrano[3,2-c]chromene derivatives following hetero-Diels–Alder reaction andin vitroanticancer studies

RSC Advances ◽  
2018 ◽  
Vol 8 (30) ◽  
pp. 16802-16814 ◽  
Author(s):  
Pravati Panda ◽  
Sabita Nayak ◽  
Susanta Ku. Sahoo ◽  
Seetaram Mohapatra ◽  
Deepika Nayak ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Alder Reaction ◽  
Diels Alder ◽  
Diastereoselective Synthesis ◽  
Diels Alder Reaction

Synthesis of novel spiro indanone fused pyrano[3,2-c]chromene derivatives following hetero-Diels–Alder reaction has been demonstrated and evaluated for theirin vitroanticancer activity.

Diastereoselective synthesis of unsaturated vicinal amino alcohols via Diels-Alder reactions of N-sulfinyl dienophiles

1984 ◽  
Vol 106 (25) ◽  
pp. 7861-7867 ◽  
Author(s):  
Ravi S. Garigipati ◽  
Alan J. Freyer ◽  
Robert R. Whittle ◽  
Steven M. Weinreb
Keyword(s):  
Amino Alcohols ◽  
Diels Alder ◽  
Diastereoselective Synthesis
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