scholarly journals CO-Induced apoptotic death of colorectal cancer cells by a luminescent photoCORM grafted on biocompatible carboxymethyl chitosan

2017 ◽  
Vol 53 (40) ◽  
pp. 5519-5522 ◽  
Author(s):  
Indranil Chakraborty ◽  
Jorge Jimenez ◽  
P. K. Mascharak
Keyword(s):  
Colorectal Cancer ◽  
Composite Material ◽  
Cancer Cells ◽  
Colorectal Adenocarcinoma ◽  
Carboxymethyl Chitosan ◽  
Caspase Activation ◽  
Apoptotic Death ◽  
Adenocarcinoma Cells ◽  
Colorectal Cancer Cells

A luminescent and Re(i) photoCORM has been grafted on biocompatible carboxymethyl chitosan (CMC). The composite material ReCMC promotes CO-induced apoptotic death of human colorectal adenocarcinoma cells through caspase activation under the control of light.

scholarly journals Wnt7a Promotes the Occurrence and Development of Colorectal Adenocarcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Congcong Li ◽  
Xiaowei Dou ◽  
Jiahuan Sun ◽  
Min Xie ◽  
Hongli Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Colorectal Adenocarcinoma ◽  
Immunohistochemical Method ◽  
Regeneration Ability ◽  
Colorectal Mucosa ◽  
Colorectal Cancer Cells ◽  
Cloning Assay ◽  
Proliferation Ability

ObjectiveThe expression of Wnt7a in colorectal cancer tissues and cell lines was analyzed, and the effect of Wnt7a on the proliferation of colorectal cancer cells was studied, so as to confirm the relationship between Wnt7a and the occurrence and development of colorectal cancer.Methods(1) Immunohistochemical method was used to compare the expression of Wnt7a in different tissues and its relationship with the clinicopathology of colorectal adenocarcinoma. (2) The expression levels of Wnt7a in colorectal cancer cell lines HT-29 and HCT 116 were detected by qRT-PCR. (3) The down-regulated Wnt7A expression vector was constructed, and the down-regulated Wnt7A expression cell line was established. The regeneration ability of cancer cells was detected by stem cell ball formation assay, and the influence of plate cloning assay on the proliferation ability of colorectal cancer cells was detected.Results(1) The positive rates of Wnt7a in normal colorectal mucosa, colorectal adenoma and colorectal adenocarcinoma tissues gradually increased,Wnt7a are closely related to the degree of colorectal adenocarcinoma differentiation, lymph node metastasis and Duke stage. (2) The expression level of Wnt7a in colorectal cancer cells was higher than that in normal colorectal epithelial cells. (3) The down-regulation of Wnt7A reduced the proliferation ability of colorectal cancer cells.ConclusionsWnt7a promotes the occurrence and development of colorectal adenocarcinoma.

scholarly journals Soluble VEGF receptor 1 (sFLT1) induces non-apoptotic death in ovarian and colorectal cancer cells

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Tatsuya Miyake ◽  
Keiichi Kumasawa ◽  
Noriko Sato ◽  
Tsuyoshi Takiuchi ◽  
Hitomi Nakamura ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Vegf Receptor ◽  
Apoptotic Death ◽  
Colorectal Cancer Cells
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