Palladium-catalyzed benzofuran and indole synthesis by multiple C–H functionalizations

2017 ◽  
Vol 53 (49) ◽  
pp. 6544-6556 ◽  
Author(s):  
Soumitra Agasti ◽  
Aniruddha Dey ◽  
Debabrata Maiti
Keyword(s):  
Natural Products ◽  
Heterocyclic Compounds ◽  
Intensive Research ◽  
The Core ◽  
Palladium Catalyzed ◽  
Indole Synthesis

Heterocyclic compounds are commonly found in the core structures of several pharmaceuticals, natural products, and agrochemicals, thus spurring intensive research for conducting their synthesis in a mild and simpler way.

Recent Advances in Directed sp2 C-H Functionalization Towards Synthesis of N-Heterocycles and O-Heterocycles

2021 ◽  
Author(s):  
Bhargav Desai ◽  
Monak Patel ◽  
Bharat Z Dholakiya ◽  
Sujoy Rana ◽  
Togati Naveen
Keyword(s):  
Natural Products ◽  
Heterocyclic Compounds ◽  
The Core ◽  
Recent Advances

Heterocyclic compounds are widely present in the core structures of several natural products, pharmaceuticals and agrochemicals thus great efforts have been ascribed for their synthesis in a mild and simpler...

Oxazole-Based Compounds As Anticancer Agents

2020 ◽  
Vol 26 (41) ◽  
pp. 7337-7371 ◽  
Author(s):  
Maria A. Chiacchio ◽  
Giuseppe Lanza ◽  
Ugo Chiacchio ◽  
Salvatore V. Giofrè ◽  
Roberto Romeo ◽  
...  
Keyword(s):  
Cancer Research ◽  
Drug Discovery ◽  
Anticancer Agents ◽  
Heterocyclic Compounds ◽  
Chemical Diversity ◽  
Biologically Active ◽  
New Drugs ◽  
The Core ◽  
Anti Cancer ◽  
Biologically Active Derivatives

: Heterocyclic compounds represent a significant target for anti-cancer research and drug discovery, due to their structural and chemical diversity. Oxazoles, with oxygen and nitrogen atoms present in the core structure, enable various types of interactions with different enzymes and receptors, favoring the discovery of new drugs. Aim of this review is to describe the most recent reports on the use of oxazole-based compounds in anticancer research, with reference to the newly discovered iso/oxazole-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. The corresponding dehydrogenated derivatives, i.e. iso/oxazolines and iso/oxazolidines, are also reported.

Formal Total Syntheses of Crocacin A-D

2005 ◽  
Vol 70 (10) ◽  
pp. 1696-1708 ◽  
Author(s):  
Magnus Besev ◽  
Christof Brehm ◽  
Alois Fürstner
Keyword(s):  
Natural Products ◽  
Aldol Reaction ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Total Syntheses ◽  
Cross Coupling Reactions ◽  
Palladium Catalyzed ◽  
The Common ◽  
Selective Addition

A concise route to the common polyketide fragment5of crocacin A-D (1-4) is presented which has previously been converted into all members of this fungicidal and cytotoxic family of dipeptidic natural products by various means. Our synthesis features asyn-selective titanium aldol reaction controlled by a valinol-derived auxiliary, a zinc-mediated, palladium-catalyzedanti-selective addition of propargyl mesylate10to the chiral aldehyde9, as well as a comparison of palladium-catalyzed Stille and Suzuki cross-coupling reactions for the formation of the diene moiety of the target.

scholarly journals Palladium-Catalyzed Coupling Reactions on Functionalized 2-Trifluoromethyl-4-chromenone Scaffolds: Synthesis of Highly Functionalized Trifluoromethyl Heterocycles

Synthesis ◽  
2018 ◽  
Vol 51 (06) ◽  
pp. 1342-1352 ◽  
Author(s):  
Javier Izquierdo ◽  
Atul Jain ◽  
Sarki Abdulkadir ◽  
Gary Schiltz
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Biological Activities ◽  
Structural Complexity ◽  
Biologically Active ◽  
Coupling Reactions ◽  
Trifluoromethyl Group ◽  
Palladium Catalyzed ◽  
Active Natural

The chromenone core is an ubiquitous group in biologically active natural products and has been extensively used in organic synthesis. Fluorine-derived compounds, including those with a trifluoromethyl group (CF3), have shown enhanced biological activities in numerous pharmaceuticals compared with their non-fluorinated analogues. 2-Trifluoromethylchromenones can be readily functionalized at the 8- and 7-positions, providing chromenones cores of high structural complexity, which are excellent precursors for numerous trifluoromethyl heterocycles.

scholarly journals Preparation of Cyclic Peptide Alkaloids Containing Functionalized Tryptophan Residues

2006 ◽  
Vol 1 (10) ◽  
pp. 1934578X0600101
Author(s):  
Alexander K. L. Yuen ◽  
Craig A. Hutton
Keyword(s):  
Natural Products ◽  
Cyclic Peptide ◽  
The Novel ◽  
Diazonamide A ◽  
The Core ◽  
Tryptophan Residues ◽  
Novel Methods

This review covers the synthesis of various cyclic peptide natural products possessing highly functionalized tryptophan residues, focusing on the examples of diazonamide A, the TMC-95 compounds, the celogentin/moroidin family and the complestatin/chloropeptin system. Recent efforts toward the preparation of these modified-tryptophan-containing peptides will be outlined, focusing primarily on the novel methods for the assembly of the highly functionalized indole/tryptophan moieties at the core of these structures.

Research Progress of N-Alkylation of Alcohol and Amine by "Hydrogen Reaction"

2021 ◽  
Vol 871 ◽  
pp. 312-317
Author(s):  
Si Min Feng ◽  
Qing Liu
Keyword(s):  
Natural Products ◽  
Heterocyclic Compounds ◽  
Amino Alcohols ◽  
New Method ◽  
Research Progress ◽  
Primary Alcohols ◽  
Ammonia Gas ◽  
Fine Chemical ◽  
Chemical Products ◽  
Amine Compounds

Amine compounds are widely found in natural products, pharmaceuticals and fine chemical products. Therefore, it is of great significance to develop methods for synthesizing amine compounds. Therefore, in recent years, a new method of synthesizing amines has been developed, namely "hydrogen borrowing reaction". This article reviews the alkylation of primary alcohols and amines, the cyclization of amino alcohols to form N-heterocyclic compounds, the reaction of diols and amines to form N-heterocyclic compounds, the reaction of alcohols and sulfonamides, and the reaction of alcohols and amines containing N heteroatoms , Alcohol and ammonia gas and ammonia to produce amine by hydrogen reaction research progress.

scholarly journals Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp2)–H activation and C(sp3)–H amination

2019 ◽  
Vol 15 ◽  
pp. 571-576 ◽  
Author(s):  
Liangliang Song ◽  
Guilong Tian ◽  
Johan Van der Eycken ◽  
Erik V Van der Eycken
Keyword(s):  
Natural Products ◽  
Functional Group ◽  
The Core

A rhodium(III)-catalyzed intramolecular oxidative annulation of O-substituted N-hydroxyacrylamides for the construction of indolizinones via sequential C(sp2)–H activation and C(sp3)–H amination has been developed. This approach shows excellent functional-group tolerance. The synthesized scaffold forms the core of many natural products with pharmacological relevance.

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