Tripartite polyionic complex (PIC) micelles as non-viral vectors for mesenchymal stem cell siRNA transfection

2017 ◽  
Vol 5 (9) ◽  
pp. 1910-1921 ◽  
Author(s):  
Sophie Raisin ◽  
Marie Morille ◽  
Claire Bony ◽  
Danièle Noël ◽  
Jean-Marie Devoisselle ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Viral Vectors ◽  
Sirna Transfection ◽  
Down Regulation ◽  
Polyionic Complex

In this study, we demonstrate that PIC micelles readily form at physiological pH in the presence of siRNA and disassemble at a pH close to that of endosomes. Internalization of the micelles in primary MSC results in the down-regulation of Runx2.

Macrophages enhance mesenchymal stem cell osteogenesis via down-regulation of reactive oxygen species

2020 ◽  
Vol 94 ◽  
pp. 103297 ◽  
Author(s):  
Meng-lin Luo ◽  
Yang Jiao ◽  
Wen-ping Gong ◽  
Yan Li ◽  
Li-na Niu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Down Regulation
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