Ion mobility derived collision cross section as an additional measure to support the rapid analysis of abused drugs and toxic compounds using electrospray ion mobility time-of-flight mass spectrometry

2018 ◽  
Vol 10 (7) ◽  
pp. 749-756 ◽  
Author(s):  
Ru Lian ◽  
Fang Zhang ◽  
Yurong Zhang ◽  
Zhongping Wu ◽  
Haiying Ye ◽  
...  
Keyword(s):  
Cross Section ◽  
Ion Mobility ◽  
Collision Cross Section ◽  
Analytical Techniques ◽  
Rapid Analysis ◽  
Rapid Screening ◽  
Additional Measure ◽  
Toxic Compounds ◽  
Flight Mass Spectrometry ◽  
Abused Drugs

Despite recent advances in analytical techniques, high-throughput and rapid screening of abused drugs and toxic compounds is imperative.

scholarly journals Ion Mobility-Derived Collision Cross Section As an Additional Measure for Lipid Fingerprinting and Identification

2014 ◽  
Vol 87 (2) ◽  
pp. 1137-1144 ◽  
Author(s):  
Giuseppe Paglia ◽  
Peggi Angel ◽  
Jonathan P. Williams ◽  
Keith Richardson ◽  
Hernando J. Olivos ◽  
...  
Keyword(s):  
Cross Section ◽  
Ion Mobility ◽  
Collision Cross Section ◽  
Additional Measure

scholarly journals Differentiation of Polyamide 6, 6.6, and 12 Contaminations in Polyolefin-Recyclates Using HPLC Coupled to Drift-Tube Ion- Mobility Quadrupole Time-of-Flight Mass Spectrometry

Polymers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2032
Author(s):  
Andrea Schweighuber ◽  
Jörg Fischer ◽  
Wolfgang Buchberger
Keyword(s):  
Cross Section ◽  
Ion Mobility ◽  
Drift Tube ◽  
Collision Cross Section ◽  
Polyamide 6 ◽  
Flight Mass Spectrometry ◽  
Marker Compounds ◽  
A Current

Recycling is a current hot topic with a focus especially on plastics. The quality of such plastic recyclates is of utmost importance for further processing because impurities lead to a reduction thereof. Contaminations originating from other polymers are highly problematic due to their immiscibility with the recyclate, leading to possible product failures. Therefore, methods for the determination of polymer impurities in recyclates should be investigated. In this paper, an approach for the identification of three different polyamide grades (polyamide 6, 6.6, and 12) is presented, applicable for the analysis of polyolefin-recyclates. An HPLC equipped with a drift-tube ion-mobility QTOF-MS was used for the identification and differentiation of compounds originating from the polyamides, which were then used as markers. These marker compounds are specific for each type and can be identified by their corresponding value of the collision cross section (CCS). After a simple sample preparation, all three types of polyamides were identified within one measurement. In particular, the problematic differentiation of polyamide 6 and 6.6 was easily made possible.

scholarly journals Recommendations for Reporting Ion Mobility Mass Spectrometry Measurements

2018 ◽  
Author(s):  
Valerie Gabelica ◽  
Alexandre A. Shvartsburg ◽  
Carlos Afonso ◽  
Perdita E. Barran ◽  
Justin L. P. Benesch ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Cross Section ◽  
Ion Mobility ◽  
Collision Cross Section ◽  
Ion Mobility Mass Spectrometry ◽  
Gas Temperature ◽  
Mobility Data ◽  
Community Effort ◽  
Primary Standards ◽  
Definition Of

Here we present a guide on ion mobility mass spectrometry experiments, which covers both linear and nonlinear methods: what is measured, how the measurements are done, and how to report the results, including the uncertainties on mobility and collision cross section values. The guide aims to clarify some possibly confusing concepts, and the reporting recommendations should help researchers, authors and reviewers to contribute comprehensive reports, so that the ion mobility data can be reused more confidently. Starting from the concept of the definition of the measurand, we emphasize that (i) mobility values (K0) depend intrinsically on ion structure, the nature of the bath gas, temperature, and E/N, (ii) ion mobility does not measure surfaces directly, but collision cross section (CCS) values are derived from mobility values using a physical model, (iii) methods relying on calibration are empirical (and thus may provide method-dependent results) only if the gas nature, temperature or E/N cannot match those of the primary method. Our analysis highlights the urgency of a community effort towards establishing primary standards and reference materials for ion mobility, and provides recommendations to do so. <br><br><br>

Rapid resolution of carbohydrate isomers via multi-site derivatization ion mobility-mass spectrometry

The Analyst ◽  
2018 ◽  
Vol 143 (4) ◽  
pp. 949-955 ◽  
Author(s):  
Li Li ◽  
Kristin R. McKenna ◽  
Zhao Li ◽  
Mahipal Yadav ◽  
Ramanarayanan Krishnamurthy ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Cross Section ◽  
Ion Mobility ◽  
Collision Cross Section ◽  
Ion Mobility Mass Spectrometry ◽  
Rapid Resolution

Identifying small sugar isomers can be challenging by ion mobility-mass spectrometry (IM-MS) alone due to their small collision cross section differences.

Collision Cross Section (CCS) Database: An Additional Measure to Characterize Steroids

2018 ◽  
Vol 90 (7) ◽  
pp. 4616-4625 ◽  
Author(s):  
Maykel Hernández-Mesa ◽  
Bruno Le Bizec ◽  
Fabrice Monteau ◽  
Ana M. García-Campaña ◽  
Gaud Dervilly-Pinel
Keyword(s):  
Cross Section ◽  
Collision Cross Section ◽  
Additional Measure

scholarly journals Assessing Collision Cross Section Calibration Strategies for Traveling Wave-Based Ion Mobility Separations in Structures for Lossless Ion Manipulations

2020 ◽  
Vol 92 (22) ◽  
pp. 14976-14982
Author(s):  
Ailin Li ◽  
Christopher R. Conant ◽  
Xueyun Zheng ◽  
Kent J. Bloodsworth ◽  
Daniel J. Orton ◽  
...  
Keyword(s):  
Cross Section ◽  
Ion Mobility ◽  
Traveling Wave ◽  
Collision Cross Section
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