Carrier assisted electromembrane extraction based on nonionic lipophilic surfactants for the determination of basic drugs in urine samples

2017 ◽  
Vol 9 (38) ◽  
pp. 5659-5667 ◽  
Author(s):  
Zolfaghar Aladaghlo ◽  
Ali Reza Fakhari ◽  
Kobra Sadat Hasheminasab
Keyword(s):  
Capillary Electrophoresis ◽  
Urine Samples ◽  
Basic Drugs ◽  
Electromembrane Extraction

Herein, an efficient carrier assisted electromembrane extraction coupled with capillary electrophoresis has been proposed for the quantitation of basic drugs (pseudoephedrine and tramadol) in urine samples.

Hollow fiber supported liquid-phase microextraction combined with maltodextrin-modified capillary electrophoresis for the determination of citalopram enantiomers in urine samples

2015 ◽  
Vol 7 (5) ◽  
pp. 2012-2019 ◽  
Author(s):  
Jafar Abolhasani ◽  
Hamid Reza Jafariyan ◽  
Mohammad Mahdi khataei ◽  
Rahim Hosseinzadeh-khanmiri ◽  
Ebrahim Ghorbani-kalhor ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Liquid Phase ◽  
Hollow Fiber ◽  
Urine Samples ◽  
Simple Method ◽  
Liquid Phase Microextraction ◽  
Supported Liquid Phase

A simple method was developed for the separation and determination of citalopram enantiomers in urine samples.

Development of a fast capillary electrophoresis method for determination of creatinine in urine samples

2007 ◽  
Vol 1171 (1-2) ◽  
pp. 140-143 ◽  
Author(s):  
Ana Carolina O. Costa ◽  
José Luiz da Costa ◽  
Fernando G. Tonin ◽  
Marina F.M. Tavares ◽  
Gustavo Amadeu Micke
Keyword(s):  
Capillary Electrophoresis ◽  
Urine Samples ◽  
Capillary Electrophoresis Method ◽  
Electrophoresis Method

Sensitive Determination of Bromate in Water Samples by Capillary Electrophoresis Coupled with Electromembrane Extraction

2015 ◽  
Vol 9 (2) ◽  
pp. 393-400 ◽  
Author(s):  
Xiaoli Zhang ◽  
Lin Guo ◽  
Dongxue Zhang ◽  
Xinxin Ge ◽  
Jiannong Ye ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Water Samples ◽  
Electromembrane Extraction ◽  
Sensitive Determination

scholarly journals Determination of Sulpiride by Capillary Electrophoresis with End-Column Electrogenerated Chemiluminescence Detection

2002 ◽  
Vol 48 (7) ◽  
pp. 1049-1058 ◽  
Author(s):  
Jifeng Liu ◽  
Weidong Cao ◽  
Haibo Qiu ◽  
Xiuhua Sun ◽  
Xiurong Yang ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Human Plasma ◽  
Phosphate Buffer ◽  
Limit Of Detection ◽  
Extraction Procedure ◽  
Fused Silica ◽  
Urine Samples ◽  
Electrogenerated Chemiluminescence ◽  
Driving Voltage

Abstract Background: Capillary electrophoresis (CE) with tris(2,2′-bipyridyl)ruthenium(II) [Ru(bpy)32+]-electrogenerated chemiluminescence (ECL) detection is a promising method for clinical analysis. In this study, a method combining CE with Ru(bpy)32+ ECL (CE-ECL) detection that can be applied to amine-containing clinical species was developed, and the performance of CE-ECL as a quantitative method for determination of sulpiride in human plasma or urine was evaluated. Methods: Sulpiride was separated by capillary zone electrophoresis in uncoated fused-silica capillaries [50 cm × 25 μm (i.d.)] filled with phosphate buffer (pH 8.0) and a driving voltage of +15 kV, with end-column Ru(bpy)32+ ECL detection. A platinum disc electrode was used as working electrode. Sulpiride in human plasma or urine samples (100 μL) was extracted by a double-step liquid-liquid extraction procedure, dried under nitrogen at 35 °C in a water bath, and reconstituted with 100 μL of filtered water. The extraction solvent was ethyl acetate–dichloromethane (5:1 by volume). Results: Under optimum conditions (pH 8.0 phosphate buffer, injection for 6 s at 10 kV, and +1.2 V as detection potential), separation of sulpiride was accomplished within 4 min. The calibration curve was linear over a concentration range of 0.05–25.0 μmol/L, and the limit of detection was 2.9 × 10−8 mol/L for sulpiride. Intra- and interday CVs for ECL intensities were <6%. Extraction recoveries of sulpiride were 95.6–101% with CVs of 2.9–6.0%. The method was clinically validated for patient plasma and urine samples. Conclusions: CE combined with Ru(bpy)32+ ECL is reproducible, precise, selective, and enables the analysis of sulpiride in human plasma and urine. It thus is of value for rapid and efficient analysis of amine-containing analytes of clinical interest.

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