Deducing disulfide patterns of cysteine-rich proteins using signature fragments produced by top-down mass spectrometry

The Analyst ◽  
2018 ◽  
Vol 143 (4) ◽  
pp. 817-823 ◽  
Author(s):  
Xiuxiu Zhao ◽  
Yue Shen ◽  
Wenjun Tong ◽  
Guanbo Wang ◽  
David D. Y. Chen
Keyword(s):  
Mass Spectrometry ◽  
Top Down ◽  
Fragment Ions ◽  
Disulfide Cleavage ◽  
Top Down Mass Spectrometry

With improved deconvolution and fragment identification strategies, we use the patterns of specific modifications of fragment ions resulted from disulfide cleavage in top-down mass spectrometry to deduce the complex disulfide patterns of cysteine-rich proteins.

TopPIC Gateway: A Web Gateway for Top-Down Mass Spectrometry Data Interpretation

2020 ◽  
Author(s):  
In Kwon Choi ◽  
Eroma Abeysinghe ◽  
Eric Coulter ◽  
Suresh Marru ◽  
Marlon Pierce ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Data Interpretation ◽  
Mass Spectrometry Data ◽  
Top Down ◽  
Top Down Mass Spectrometry

Top-down mass spectrometry

2008 ◽  
Vol 5 (1) ◽  
pp. 24-24 ◽  
Author(s):  
Allison Doerr
Keyword(s):  
Mass Spectrometry ◽  
Top Down ◽  
Top Down Mass Spectrometry

scholarly journals Quantifying Positional Isomers (QPI) by Top-Down Mass Spectrometry

2021 ◽  
Vol 20 ◽  
pp. 100070
Author(s):  
Andrea M. Brunner ◽  
Philip Lössl ◽  
Paul P. Geurink ◽  
Huib Ovaa ◽  
P. Albanese ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Positional Isomers ◽  
Top Down ◽  
Top Down Mass Spectrometry

Extensive Characterization of the Human Salivary Basic Proline-Rich Protein Family by Top-Down Mass Spectrometry

2018 ◽  
Vol 17 (9) ◽  
pp. 3292-3307 ◽  
Author(s):  
Alessandra Padiglia ◽  
Roberto Orrù ◽  
Mozhgan Boroumand ◽  
Alessandra Olianas ◽  
Barbara Manconi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Protein Family ◽  
Top Down ◽  
Proline Rich Protein ◽  
Top Down Mass Spectrometry

Top-Down Mass Spectrometry for Trace Level Quantification of Staphylococcal Enterotoxin A Variants

2021 ◽  
Author(s):  
Donatien Lefebvre ◽  
François Fenaille ◽  
Déborah Merda ◽  
Kevin Blanco-Valle ◽  
Cécile Feraudet-Tarisse ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin A ◽  
Top Down ◽  
Trace Level ◽  
Top Down Mass Spectrometry

scholarly journals Evaluation of top-down mass spectrometry and ion-mobility spectroscopy as a means of mapping protein-binding motifs within heparin chains

The Analyst ◽  
2020 ◽  
Vol 145 (8) ◽  
pp. 3090-3099 ◽  
Author(s):  
Yunlong Zhao ◽  
Igor A. Kaltashov
Keyword(s):  
Mass Spectrometry ◽  
Protein Binding ◽  
Ion Mobility ◽  
Structural Elements ◽  
Client Protein ◽  
Top Down ◽  
Binding Motifs ◽  
Ion Mobility Spectroscopy ◽  
High Degree ◽  
Top Down Mass Spectrometry

Identifying structural elements within glycosaminoglycans that enable their interaction with a specific client protein remains a challenging task due to the high degree of both intra- and inter-chain heterogeneity exhibited by this polysaccharide.

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