Reaction screening and optimization of continuous-flow atropine synthesis by preparative electrospray mass spectrometry

The Analyst ◽  
2017 ◽  
Vol 142 (15) ◽  
pp. 2836-2845 ◽  
Author(s):  
Caitlin E. Falcone ◽  
Zinia Jaman ◽  
Michael Wleklinski ◽  
Andy Koswara ◽  
David H. Thompson ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Continuous Flow ◽  
Electrospray Mass Spectrometry ◽  
Microfluidic System ◽  
Rapid Screening ◽  
Optimization Approach ◽  
Ms Analysis

Reaction mixtures are screened by droplet ES synthesis; optimum reagents and conditions as determined using MS analysis are then transferred to a microfluidic system. This rapid screening/optimization approach is applied to the synthesis of atropine.

Interaction of Palladium(II) and Platinum(II) Complexes with Microperoxidase-11 Studied by Electrospray Mass Spectrometry and MS/MS Analysis

2004 ◽  
Vol 43 (1) ◽  
pp. 290-296 ◽  
Author(s):  
Xiaojuan Sun ◽  
Chen Jin ◽  
Yuhua Mei ◽  
Gaosheng Yang ◽  
Zijian Guo ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Mass Spectrometry ◽  
Ms Analysis

scholarly journals A rapid screening, ‘combinatorial-type’ survey of the metalloligand chemistry of Pt2(PPh3)4(μ-S)2 using electrospray mass spectrometry

2001 ◽  
pp. 421-422 ◽  
Author(s):  
S.-W. Audi Fong ◽  
Jagadese J. Vittal ◽  
T. S. Andy Hor ◽  
William Henderson ◽  
Allen G. Oliver ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Mass Spectrometry ◽  
Rapid Screening ◽  
Combinatorial Type

Continuous-Flow, On-Line Monitoring of Biospecific Interactions Using Electrospray Mass Spectrometry

2001 ◽  
Vol 73 (16) ◽  
pp. 3816-3823 ◽  
Author(s):  
A. C. Hogenboom ◽  
A. R. de Boer ◽  
R. J. E. Derks ◽  
H. Irth
Keyword(s):  
Mass Spectrometry ◽  
Continuous Flow ◽  
Electrospray Mass Spectrometry ◽  
On Line ◽  
Biospecific Interactions

scholarly journals Simple Analytical Strategy for Screening Three Synthetic Cathinones (α-PVT, α-PVP, and MDPV) in Oral Fluids

Analytica ◽  
2022 ◽  
Vol 3 (1) ◽  
pp. 14-23
Author(s):  
André M. Segurado ◽  
Samir M. Ahmad ◽  
Nuno R. Neng ◽  
Margarida M. Maniés-Sequeira ◽  
Helena Gaspar ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Synthetic Cathinones ◽  
Rapid Screening ◽  
Biological Matrices ◽  
Analytical Methodology ◽  
Analytical Strategy ◽  
Oral Fluids ◽  
Ms Analysis ◽  
Analytical Approaches

Synthetic cathinones are analogue compounds of the plant based stimulant cathinone. Its use, abuse, and related consumption complications have steadily increased in the last years. For this reason, there is a need for innovative analytical approaches that enable its rapid screening in biological matrices (e.g., oral fluids). The present work proposes a new analytical methodology by combining bar adsorptive microextraction followed by microliquid desorption and gas chromatography coupled to mass spectrometry (BAµE-µLD/GC-MS) for screening three synthetic cathinones (α-PVP, α-PVT, and MDPV) in oral fluids. The optimization of the BAµE-µLD/GC-MS methodology was successfully applied for the analysis of the target compounds in oral fluids. The results show average recoveries between 43.1 and 52.3% for the three synthetic cathinones. Good selectivity was also noticed. The developed methodology presents itself as an alternative tool to screen these compounds in oral fluids. To the best of our knowledge, this is the first work that combines a microextraction sorption-based technique followed by GC-MS analysis for the screening of synthetic cathinones in oral fluids.

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