An electrochemiluminescence assay for sensitive detection of methyltransferase activity in different cancer cells by hybridization chain reaction coupled with a G-quadruplex/hemin DNAzyme biosensing strategy

The Analyst ◽  
2017 ◽  
Vol 142 (11) ◽  
pp. 2013-2019 ◽  
Author(s):  
Hui Zhang ◽  
Zhihui Guo ◽  
Huilei Dong ◽  
Hongfei Chen ◽  
Chenxin Cai
Keyword(s):  
Cancer Cells ◽  
Sensitive Detection ◽  
Hybridization Chain Reaction ◽  
Methyltransferase Activity ◽  
Chain Reaction ◽  
G Quadruplex

A sensitive electrochemiluminescence assay coupled HCR with a G-quadruplex/hemin DNAzyme was fabricated for the detection of DNMT1 activity in cancer cells.

Highly sensitive detection of cancer cells via split aptamer mediated proximity-induced hybridization chain reaction

Talanta ◽  
2021 ◽  
Vol 223 ◽  
pp. 121724
Author(s):  
Lie Li ◽  
Huishan Jiang ◽  
Xiangxian Meng ◽  
Xiaohong Wen ◽  
Qiuping Guo ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Sensitive Detection ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

Lab in a tube: a fast-assembled colorimetric sensor for highly sensitive detection of oligonucleotides based on a hybridization chain reaction

RSC Advances ◽  
2015 ◽  
Vol 5 (55) ◽  
pp. 44714-44721 ◽  
Author(s):  
Siqi Zhang ◽  
Kun Wang ◽  
Zhenyu Li ◽  
Zhongmin Feng ◽  
Ting Sun
Keyword(s):  
Complex Formation ◽  
Dna Sequence ◽  
Self Assembly ◽  
The Self ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Highly Sensitive ◽  
G Quadruplex ◽  
Colored Product ◽  
Highly Sensitive Detection

Upon adding THBV, the self-assembly of THBV with H1 allows the rest of the DNA sequence of H1 to accelerate H1–H2 complex formation. The G-quadruplex at the end of the H1–H2 complex could catalyze TMB into a colored product.

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