A simple functional carbon nanotube fiber for in vivo monitoring of NO in a rat brain following cerebral ischemia

The Analyst ◽  
2017 ◽  
Vol 142 (9) ◽  
pp. 1452-1458 ◽  
Author(s):  
Li Liu ◽  
Limin Zhang ◽  
Zhihui Dai ◽  
Yang Tian
Keyword(s):  
Carbon Nanotube ◽  
Cerebral Ischemia ◽  
Rat Brain ◽  
Electrochemical Biosensor ◽  
In Vivo Monitoring ◽  
Carbon Nanotube Fiber

A simple ratiometric electrochemical biosensor for NO monitoring in rat brain following cerebral ischemia was developed based on a carbon nanotube fiber modified with hemin.

A Two-Channel Ratiometric Electrochemical Biosensor for In Vivo Monitoring of Copper Ions in a Rat Brain Using Gold Truncated Octahedral Microcages

2013 ◽  
Vol 125 (31) ◽  
pp. 8287-8291 ◽  
Author(s):  
Xiaolan Chai ◽  
Xinguang Zhou ◽  
Anwei Zhu ◽  
Limin Zhang ◽  
Yao Qin ◽  
...  
Keyword(s):  
Rat Brain ◽  
Electrochemical Biosensor ◽  
Copper Ions ◽  
In Vivo Monitoring

Low-Fouling Nanoporous Conductive Polymer-Coated Microelectrode for In Vivo Monitoring of Dopamine in the Rat Brain

2019 ◽  
Vol 91 (16) ◽  
pp. 10786-10791 ◽  
Author(s):  
Taotao Feng ◽  
Wenliang Ji ◽  
Qiao Tang ◽  
Huan Wei ◽  
Shuai Zhang ◽  
...  
Keyword(s):  
Rat Brain ◽  
Conductive Polymer ◽  
In Vivo Monitoring

scholarly journals In Vivo Microdialysis of Endogenous and 13C-labeled TCA Metabolites in Rat Brain: Reversible and Persistent Effects of Mitochondrial Inhibition and Transient Cerebral Ischemia

Metabolites ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 204 ◽  
Author(s):  
Jesper F. Havelund ◽  
Kevin H. Nygaard ◽  
Troels H. Nielsen ◽  
Carl-Henrik Nordström ◽  
Frantz R. Poulsen ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Mitochondrial Dysfunction ◽  
Rat Brain ◽  
De Novo ◽  
Tricarboxylic Acid Cycle ◽  
Experimental Models ◽  
Transient Cerebral Ischemia ◽  
Metabolic Disturbances ◽  
Metabolic Marker

Cerebral micro-dialysis allows continuous sampling of extracellular metabolites, including glucose, lactate and pyruvate. Transient ischemic events cause a rapid drop in glucose and a rise in lactate levels. Following such events, the lactate/pyruvate (L/P) ratio may remain elevated for a prolonged period of time. In neurointensive care clinics, this ratio is considered a metabolic marker of ischemia and/or mitochondrial dysfunction. Here we propose a novel, sensitive microdialysis liquid chromatography-mass spectrometry (LC-MS) approach to monitor mitochondrial dysfunction in living brain using perfusion with 13C-labeled succinate and analysis of 13C-labeled tricarboxylic acid cycle (TCA) intermediates. This approach was evaluated in rat brain using malonate-perfusion (10–50 mM) and endothelin-1 (ET-1)-induced transient cerebral ischemia. In the malonate model, the expected changes upon inhibition of succinate dehydrogenase (SDH) were observed, i.e., an increase in endogenous succinate and decreases in fumaric acid and malic acid. The inhibition was further elaborated by incorporation of 13C into specific TCA intermediates from 13C-labeled succinate. In the ET-1 model, increases in non-labeled TCA metabolites (reflecting release of intracellular compounds) and decreases in 13C-labeled TCA metabolites (reflecting inhibition of de novo synthesis) were observed. The analysis of 13C incorporation provides further layers of information to identify metabolic disturbances in experimental models and neuro-intensive care patients.

In Vivo Monitoring of Oxygen in Rat Brain by Carbon Fiber Microelectrode Modified with Antifouling Nanoporous Membrane

2019 ◽  
Vol 91 (5) ◽  
pp. 3645-3651 ◽  
Author(s):  
Lin Zhou ◽  
Hanfeng Hou ◽  
Huan Wei ◽  
Lina Yao ◽  
Lei Sun ◽  
...  
Keyword(s):  
Carbon Fiber ◽  
Rat Brain ◽  
Nanoporous Membrane ◽  
In Vivo Monitoring ◽  
Carbon Fiber Microelectrode

scholarly journals In Vivo Monitoring of Inflammation After Cardiac and Cerebral Ischemia by Fluorine Magnetic Resonance Imaging

Circulation ◽  
2008 ◽  
Vol 118 (2) ◽  
pp. 140-148 ◽  
Author(s):  
Ulrich Flögel ◽  
Zhaoping Ding ◽  
Hendrik Hardung ◽  
Sebastian Jander ◽  
Gaby Reichmann ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cerebral Ischemia ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
In Vivo Monitoring ◽  
Fluorine Magnetic Resonance Imaging
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