scholarly journals Paraquat disrupts the anti-inflammatory action of cortisol in human macrophages in vitro: therapeutic implications for paraquat intoxications

2017 ◽  
Vol 6 (2) ◽  
pp. 232-241 ◽  
Author(s):  
Gesiele Veríssimo ◽  
Aalt Bast ◽  
Antje R. Weseler
Keyword(s):  
Inflammatory Response ◽  
Human Macrophages ◽  
Therapeutic Implications ◽  
Anti Inflammatory ◽  
Inflammatory Action

The herbicide paraquate (1,1′-dimethyl-4,4′-bipyridinium dichloride) induces an inflammatory response in human macrophages which cannot be attenuated by cortisol.

scholarly journals Dangguijakyak-San Protects against 1-Methyl-4-phenyl-1,2,3,6,-tetrahydropyridine-Induced Neuronal Damage via Anti-Inflammatory Action

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Deok-Sang Hwang ◽  
Hyo Geun Kim ◽  
Jun-Bock Jang ◽  
Myung Sook Oh
Keyword(s):  
Neuronal Damage ◽  
Cell Damage ◽  
Substantia Nigra Pars Compacta ◽  
Inflammatory Factors ◽  
Dopaminergic Cell ◽  
Therapeutic Implications ◽  
Anti Inflammatory ◽  
Inflammatory Action

Dangguijakyak-san (DJS), a famous traditional Korean multiherbal medicine, has been used to treat gynecological and neuro-associated disease. Recent studies demonstrated that DJS has multiple bioactivities including neuroprotection. In the present study, we were to investigate the effect of DJS and its mechanism in anin vitroandin vivomodel of Parkinson’s disease (PD). In primary mesencephalic culture system, DJS attenuated the dopaminergic cell damage induced by 1-methyl-4-phenylpyridine toxicity, and it inhibited production of inflammatory factors such as tumor necrosis factorα(TNF-α), nitric oxide (NO), and activation of microglial cells. Then, we confirmed the effect of DJS in a mouse PD model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In the pole test, DJS at 50 mg/kg/day for 5 days showed increase of motor activity showing shortened time to turn and locomotor activity compared with the MPTP only treated mice. In addition, DJS significantly protected nigrostriatal dopaminergic neuron from MPTP stress. Moreover, DJS showed inhibition of gliosis in the substantia nigra pars compacta. These results have therapeutic implications for DJS in the treatment of PD via anti-inflammatory effects.

scholarly journals Triticum vulgare extract exerts an anti-inflammatory action in two in vitro models of inflammation in microglial cells

PLoS ONE ◽  
2018 ◽  
Vol 13 (6) ◽  
pp. e0197493 ◽  
Author(s):  
Luca Sanguigno ◽  
Antonella Casamassa ◽  
Niccola Funel ◽  
Massimiliano Minale ◽  
Rodolfo Riccio ◽  
...  
Keyword(s):  
In Vitro Models ◽  
Microglial Cells ◽  
Triticum Vulgare ◽  
Anti Inflammatory ◽  
Inflammatory Action

scholarly journals An Ethanolic Extract of Boehmeria caudata Aerial Parts Displays Anti-inflammatory and Anti-tumor Activities

2020 ◽  
Vol 7 (01) ◽  
pp. e17-e25 ◽  
Author(s):  
Paula Pereira de Paiva ◽  
Fabiana Regina Nonato ◽  
Ana Lúcia Tasca Gois Ruiz ◽  
Ilza Maria de Oliveira Sousa ◽  
Rafael Rosolen Teixeira Zafred ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Ethanolic Extract ◽  
Experimental Models ◽  
New Drugs ◽  
Antiproliferative Effects ◽  
Aerial Parts ◽  
Anti Inflammatory ◽  
Inflammatory Action ◽  
Effective Source

AbstractThe tumor microenvironment presents several therapeutic targets, with inflammation being one of them. In search of new drugs, plants have shown to be an effective source of potent anti-inflammatory and anticancer agents. This study aimed to evaluate the antitumoral and inflammatory activities of Boehmeria caudata aerial parts extract. Bioguided in vitro antiproliferative screening showed that phenanthroquinolizidine obtained from the aerial B. caudata ethanolic extract had a straight relationship with activity. Moreover, the orally administered ethanolic extract reduced Ehrlich solid tumor growth and displayed an anti-inflammatory effect in both evaluated experimental models (carrageenan-induced paw edema and croton oil-induced ear edema). These results suggest that the antitumor activity of the ethanolic extract could be explained by antiproliferative effects associated with anti-inflammatory action.

In vitro anti-inflammatory properties of Smilax campestris aqueous extract in human macrophages, and characterization of its flavonoid profile

2020 ◽  
Vol 247 ◽  
pp. 112282 ◽  
Author(s):  
Luciana S. Salaverry ◽  
Andrea C. Parrado ◽  
Franco M. Mangone ◽  
Cecilia B. Dobrecky ◽  
Sabrina A. Flor ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Human Macrophages ◽  
Anti Inflammatory

scholarly journals Platelet‐rich fibrin elicits an anti‐inflammatory response in macrophages in vitro

2019 ◽  
Vol 91 (2) ◽  
pp. 244-252 ◽  
Author(s):  
Jila Nasirzade ◽  
Zahra Kargarpour ◽  
Sadegh Hasannia ◽  
Franz Josef Strauss ◽  
Reinhard Gruber
Keyword(s):  
Inflammatory Response ◽  
Platelet Rich Fibrin ◽  
Anti Inflammatory

In-vitro and in-vivo anti-inflammatory action of the ethanol extract ofTrachelospermi caulis

2007 ◽  
Vol 59 (1) ◽  
pp. 123-130 ◽  
Author(s):  
Mu Hong Lee ◽  
Jeong Min Lee ◽  
Sung Hoon Jun ◽  
Chul Gyu Ha ◽  
Seung-Ha Lee ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Anti Inflammatory ◽  
Inflammatory Action

scholarly journals Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Yiyi Jin ◽  
Jianchang Qian ◽  
Xin Ju ◽  
Xiaodong Bao ◽  
Li Li ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Inflammatory Response ◽  
Nuclear Translocation ◽  
Tissue Injury ◽  
Kidney Injury ◽  
Peritoneal Macrophages ◽  
Anti Inflammatory

Inflammation is a key factor in the pathogenesis of ALI. Therefore, suppression of inflammatory response could be a potential strategy to treat LPS-induced lung injury. Osthole, a natural coumarin extract, has been reported to protect against acute kidney injury through an anti-inflammatory mechanism, but its effect on ALI is poorly understood. In this study, we investigated whether osthole ameliorates inflammatory sepsis-related ALI. Results from in vitro studies indicated that osthole treatment inhibited the LPS-induced inflammatory response in mouse peritoneal macrophages through blocking the nuclear translocation of NF-κB. Consistently, the in vivo studies indicated that osthole significantly prolonged the survival of septic mice which was accompanied by inflammation suppression. In the ALI mouse model, osthole effectively inhibited the development of lung tissue injury, leukocytic recruitment, and cytokine productions, which was associated with inhibition of NF-κB nuclear translocation. These findings provide evidence that osthole was a potent inhibitor of NF-κB and inflammatory injury and suggest that it could be a promising anti-inflammatory agent for therapy of septic shock and acute lung injury.

scholarly journals Synthesis, Molecular Docking and Biological Properties of Novel Thiazolo[4,5-b]pyridine Derivatives

2020 ◽  
Vol 67 (4) ◽  
pp. 1035-1043
Author(s):  
Taras I. Chaban ◽  
Yulia E. Matiichuk ◽  
Olga Ya. Shyyka ◽  
Ihor G. Chaban ◽  
Volodymyr V. Ogurtsov ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Antioxidant Properties ◽  
Biological Properties ◽  
Pharmacological Profile ◽  
Scavenging Effect ◽  
Rat Paw Edema ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Inflammatory Action

The synthesis, anti-inflammatory and antioxidant properties of novel 5-hydroxy-7-methyl-3H-thiazolo[4,5-b]pyridin-2-one derivatives were discussed. Fused thiazolo[4,5-b]pyridin-2-ones were synthesized and modified at the N3, C5 and C6 positions of the main core in order to obtain the compounds with a satisfactory pharmacological profile. The synthesized compounds were preselected via molecular docking for further testing of their anti-inflammatory activity in vitro. Evaluation of novel compounds over the carageenin induced rat paw edema revealed strong anti-inflammatory action of some compounds including (thiazolo[4,5-b]pyridin-3(2H)-yl) propanenitrile (5) and thiazolo[4,5-b]pyridin-3(2H)-yl) propanoic acid (6) even exceeding the standard – Ibuprofen. The antioxidant activity of the synthesized compounds was measured in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.

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