scholarly journals Effects of sorafenib and cisplatin on preneoplastic foci of altered hepatocytes in fetal turkey liver

2017 ◽  
Vol 6 (1) ◽  
pp. 54-62
Author(s):  
Bettina Kaestner ◽  
Karsten Spicher ◽  
Ulrich Jaehde ◽  
Harald Enzmann
Keyword(s):  
Cell Proliferation ◽  
Promotion Effect ◽  
Preneoplastic Foci ◽  
Foci Of Altered Hepatocytes

Foci of altered hepatocytes (FAH) were induced in fetal turkey liver (FTL) by diethyl nitrosamine. Sorafenib but not cisplatin enhanced the development of FAH by increasing cell proliferation. This is indicative of a potential promotion effect of sorafenib on hepatocarcinogenesis.

The Ras inhibitor farnesylthiosalicyclic acid (FTS) prevents nodule formation and development of preneoplastic foci of altered hepatocytes in rats

2009 ◽  
Vol 45 (11) ◽  
pp. 2050-2060 ◽  
Author(s):  
T. Schneider-Merck ◽  
I. Borbath ◽  
N. Charette ◽  
C. De Saeger ◽  
J. Abarca ◽  
...  
Keyword(s):  
Nodule Formation ◽  
Preneoplastic Foci ◽  
Foci Of Altered Hepatocytes

Preneoplastic foci of altered hepatocytes induced in rats by irradiation with α-particles of Thorotrast and neutrons

1994 ◽  
Vol 83 (1-2) ◽  
pp. 81-88 ◽  
Author(s):  
Steffi Ober ◽  
Heide Zerban ◽  
Andreas Spiethoff ◽  
Kurt Wegener ◽  
Michael Schwarz ◽  
...  
Keyword(s):  
Preneoplastic Foci ◽  
Foci Of Altered Hepatocytes ◽  
Α Particles

scholarly journals Cell proliferation and apoptosis in normal liver and preneoplastic foci.

1993 ◽  
Vol 101 (suppl 5) ◽  
pp. 87-90 ◽  
Author(s):  
R Schulte-Hermann ◽  
W Bursch ◽  
B Kraupp-Grasl ◽  
F Oberhammer ◽  
A Wagner ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Normal Liver ◽  
Proliferation And Apoptosis ◽  
Preneoplastic Foci

scholarly journals The promotion effect of anorectic drugs on aflatoxin B1-induced hepatic preneoplastic foci

1999 ◽  
Vol 20 (9) ◽  
pp. 1793-1799 ◽  
Author(s):  
Xu Lin ◽  
David A. Levitsky ◽  
John M. King ◽  
T. Colin Campbell
Keyword(s):  
Aflatoxin B1 ◽  
Promotion Effect ◽  
Anorectic Drugs ◽  
Preneoplastic Foci

Quercetin inhibited the proliferation and invasion of hepatoblastoma cells through facilitating SIRT6-medicated FZD4 silence

2021 ◽  
pp. 096032712110305
Author(s):  
T Liu ◽  
Z Li ◽  
F Tian
Keyword(s):  
Cell Proliferation ◽  
Tumor Growth ◽  
Cell Viability ◽  
Cell Apoptosis ◽  
Malignant Liver Tumor ◽  
Promotion Effect ◽  
Malignant Liver ◽  
Related Proteins ◽  
Proliferation And Invasion

Hepatoblastoma (HB) is a malignant liver tumor that occurs during childhood. The histone deacetylase SIRT6 functions as a tumor suppressor in diverse cancers. Quercetin, as activators and antioxidants of sirtuins, exhibits remarkable anticancer activity in many tumors. However, whether quercetin ameliorates HB is still unclear. In our study, we found that SIRT6 was downregulated in HB tissues and cell lines. Overexpression of SIRT6 observably suppressed cell proliferation and invasion, promoted cell apoptosis. Mechanistically, SIRT6 suppressed frizzled 4 (FZD4) transcription by deacetylating histone H3K9. Upregulation of SIRT6 reduced the protein levels of FZD4 and H3K9ac. Additionally, quercetin treatment could enhance the expression of SIRT6, repress FZD4 level, cell viability and invasion, and promote apoptosis. Overexpression of FZD4 signally reversed quercetin-treated the promotion effect on cell apoptosis, and the inhibition effects on FZD4 expression, cell viability, invasion and Wnt/β-catenin pathway related proteins. In addition, LiCl, an agonist of Wnt/β-catenin pathway, could recover the inhibition effects of quercetin on Wnt/β-catenin pathway related proteins, cell viability and invasion, and promotion effect on cell apoptosis. In vivo mouse xenograft tumor growth assay revealed that quercetin markedly suppressed tumor growth. In conclusion, these results demonstrated that the molecular mechanism of quercetin suppressing HB cell proliferation and invasion, promoting apoptosis was to promote the deacetylation of SIRT6 on FZD4 and inhibit the activation of Wnt/β-catenin pathway.

scholarly journals Cell Proliferation and Apoptosis in Normal Liver and Preneoplastic Foci

1993 ◽  
Vol 101 ◽  
pp. 87 ◽  
Author(s):  
Rolf Schulte-Hermann ◽  
Wilfried Bursch ◽  
Bettina Kraupp-Grasl ◽  
Franziska Oberhammer ◽  
Alexandra Wagner ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Normal Liver ◽  
Proliferation And Apoptosis ◽  
Preneoplastic Foci

Fibroblasts During Hypertrophic Scar Formation and Resolution

1973 ◽  
Vol 31 ◽  
pp. 428-429
Author(s):  
C. W. Kischer
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Cell Proliferation ◽  
Fine Structure ◽  
Metabolic Activity ◽  
Hypertrophic Scar ◽  
Normal Skin ◽  
Ground Substance ◽  
Hypertrophic Scars ◽  
Scanning Electron

The morphology of the fibroblasts changes markedly as the healing period from burn wounds progresses, through development of the hypertrophic scar, to resolution of the scar by a self-limiting process of maturation or therapeutic resolution. In addition, hypertrophic scars contain an increased cell proliferation largely made up of fibroblasts. This tremendous population of fibroblasts seems congruous with the abundance of collagen and ground substance. The fine structure of these cells should reflect some aspects of the metabolic activity necessary for production of the scar, and might presage the stage of maturation.A comparison of the fine structure of the fibroblasts from normal skin, different scar types, and granulation tissue has been made by transmission (TEM) and scanning electron microscopy (SEM).

The Effect of Androgen Depletion and Replacement on the Epithelium of the Seminal Vesicle of the Aging Rat

1975 ◽  
Vol 33 ◽  
pp. 590-591
Author(s):  
Venita F. Allison
Keyword(s):  
Cell Proliferation ◽  
Seminal Vesicle ◽  
Male Rats ◽  
Target Cells ◽  
Cell Regeneration ◽  
Secretory Function ◽  
Electron Microscopic ◽  
Aging Rat ◽  
Microscopic Studies ◽  
Androgen Depletion

In 1930, Moore, Hughes and Gallager reported that after castration seminal vesicle epithelial cell atrophy occurred and that cell regeneration could be achieved with daily injections of testis extract. Electron microscopic studies have confirmed those observations and have shown that testosterone injections restore the epithelium of the seminal vesicle in adult castrated male rats. Studies concerned with the metabolism of androgens point out that dihydrotestosterone stimulates cell proliferation and that other metabolites of testosterone probably influence secretory function in certain target cells.Although the influence of androgens on adult seminal vesicle epithelial cytology is well documented, little is known of the effect of androgen depletion and replacement on those cells in aging animals. The present study is concerned with the effect of castration and testosterone injection on the epithelium of the seminal vesicle of aging rats.

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