The study of the pseudo-polyrotaxane architecture as a route for mild surface functionalization by click chemistry of poly(ε-caprolactone)-based electrospun fibers

2017 ◽  
Vol 5 (11) ◽  
pp. 2181-2189 ◽  
Author(s):  
M. Oster ◽  
G. Schlatter ◽  
S. Gallet ◽  
R. Baati ◽  
E. Pollet ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Surface Functionalization ◽  
Biomedical Applications ◽  
Copper Catalysts ◽  
Electrospun Fibers

PCL fibers with pseudopolyrotaxanes at their surface are functionalized with bicyclononyne clickable groups making possible an easy bioconjugation in water and without copper catalysts for biomedical applications.

scholarly journals Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2896
Author(s):  
Sara Ferraris ◽  
Silvia Spriano ◽  
Alessandro Calogero Scalia ◽  
Andrea Cochis ◽  
Lia Rimondini ◽  
...  
Keyword(s):  
Surface Modification ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Electrospun Fibers ◽  
Natural Polymers ◽  
Polymeric Fibers ◽  
Biological Phenomena ◽  
Proper Design ◽  
Synthetic And Natural Polymers ◽  
Selection Of

Electrospinning is gaining increasing interest in the biomedical field as an eco-friendly and economic technique for production of random and oriented polymeric fibers. The aim of this review was to give an overview of electrospinning potentialities in the production of fibers for biomedical applications with a focus on the possibility to combine biomechanical and topographical stimuli. In fact, selection of the polymer and the eventual surface modification of the fibers allow selection of the proper chemical/biological signal to be administered to the cells. Moreover, a proper design of fiber orientation, dimension, and topography can give the opportunity to drive cell growth also from a spatial standpoint. At this purpose, the review contains a first introduction on potentialities of electrospinning for the obtainment of random and oriented fibers both with synthetic and natural polymers. The biological phenomena which can be guided and promoted by fibers composition and topography are in depth investigated and discussed in the second section of the paper. Finally, the recent strategies developed in the scientific community for the realization of electrospun fibers and for their surface modification for biomedical application are presented and discussed in the last section.

Surface Modification of Ti-30Ta Alloy by Electrospun PCL Deposition

2016 ◽  
Vol 869 ◽  
pp. 930-934
Author(s):  
Cristiane Mayumi Wada ◽  
André Luiz Reis Rangel ◽  
Marisa Aparecida de Souza ◽  
Rosemeire dos Santos Almeida ◽  
Marcos Akira D’Ávila ◽  
...  
Keyword(s):  
Contact Angle ◽  
Plasma Treatment ◽  
Biomedical Applications ◽  
Plasma Reactor ◽  
Melting Furnace ◽  
Argon Atmosphere ◽  
Electrospun Fibers ◽  
X Rays ◽  
Arc Melting ◽  
Hydrophilic Behavior

In this study, PCL electrospun fibers were deposited on the Ti-30Ta alloy for change the surface properties. Experimental Ti-30Ta alloy was obtained by melting titanium and tantalum in arc melting furnace with argon atmosphere. Ingots were homogenized and bars with 10 mm of diameter were obtained in rotative swagging. PCL fibers were deposited on disks of the alloy by electrospinning. Plasma treatment was carried out for change PCL electrospun superficial energy by using stainless steel plasma reactor. Samples were immersed in mineralization solution for apatite growth. Surfaces were evaluated by using SEM, X-rays diffraction and contact angle. Samples exhibited hydrophilic behavior after plasma treatment and mineralization. Results are very interesting for biomedical applications.

scholarly journals Electrospun Azido-PCL Nanofibers for Enhanced Surface Functionalization by Click Chemistry

2012 ◽  
Vol 4 (12) ◽  
pp. 6499-6504 ◽  
Author(s):  
Anica Lancuški ◽  
Sébastien Fort ◽  
Frédéric Bossard
Keyword(s):  
Click Chemistry ◽  
Surface Functionalization ◽  
Enhanced Surface

Site-Specific Surface Functionalization via Microchannel Cantilever Spotting (µCS): Comparison between Azide-Alkyne and Thiol-Alkyne Click Chemistry Reactions

Small ◽  
2018 ◽  
Vol 14 (21) ◽  
pp. 1800131 ◽  
Author(s):  
Seyed Mohammad Mahdi Dadfar ◽  
Sylwia Sekula-Neuner ◽  
Uwe Bog ◽  
Vanessa Trouillet ◽  
Michael Hirtz
Keyword(s):  
Specific Surface ◽  
Click Chemistry ◽  
Surface Functionalization ◽  
Site Specific

Dendrimer Synthesis and Functionalization by Click Chemistry for Biomedical Applications

2009 ◽  
pp. 177-193 ◽  
Author(s):  
Daniel Q. McNerny ◽  
Douglas G. Mullen ◽  
Istvan J. Majoros ◽  
Mark M. Banaszak Holl ◽  
James R. Baker
Keyword(s):  
Click Chemistry ◽  
Biomedical Applications

Understanding drug release from PCL/gelatin electrospun blends

2016 ◽  
Vol 31 (6) ◽  
pp. 933-949 ◽  
Author(s):  
Hrishikesh R Munj ◽  
John J Lannutti ◽  
David L Tomasko
Keyword(s):  
Drug Release ◽  
Biomedical Applications ◽  
Drug Loading ◽  
Release Mechanism ◽  
Electrospun Fibers ◽  
Electrospun Scaffolds ◽  
Bioactive Properties ◽  
Complex Process ◽  
Rhodamine B Dye ◽  
Polymer Erosion

Electrospinning is one of the efficient processes to fabricate polymeric fibrous scaffolds for several biomedical applications. Several studies have published to demonstrate drug release from electrospun scaffolds. Blends of natural and synthetic electrospun fibers provide excellent platform to combine mechanical and bioactive properties. Drug release from polymer blends is a complex process. Drug release from polymer can be dominated by one or more of following mechanisms: polymer erosion, relaxation, and degradation. In this study, electrospun polycaprolactone (PCL)–gelatin blends are investigated to understand release mechanism of Rhodamine B dye. Also, this article summarizes the effect of high-pressure carbon dioxide on drug loading and release from PCL–gelatin fibers. Results indicate that release media diffusion is a dominant mechanism for PCL–gelatin electrospun fibers. Thickness of electrospun mat becomes critical for blends with gelatin. As gelatin is highly soluble in water and has tendency of gelation, it affects diffusion of release media in and out of scaffold. This article is a key step forward in understanding release from electrospun blends.

scholarly journals Electrochemical Multiplexing: Control over Surface Functionalization by Combining a Redox-Sensitive Alkyne Protection Group with “Click”-Chemistry

2019 ◽  
Vol 6 (5) ◽  
pp. 1801917 ◽  
Author(s):  
Manuel Hellstern ◽  
Markus Gantenbein ◽  
Loïc Le Pleux ◽  
Gabriel Puebla-Hellmann ◽  
Emanuel Lörtscher ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Surface Functionalization
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