Blood clot initiation by mesoporous silica nanoparticles: dependence on pore size or particle size?

2016 ◽  
Vol 4 (44) ◽  
pp. 7146-7154 ◽  
Author(s):  
Zihao Chen ◽  
Fan Li ◽  
Changjun Liu ◽  
Jing Guan ◽  
Xiao Hu ◽  
...  
Keyword(s):  
Particle Size ◽  
Mesoporous Silica ◽  
Pore Size ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Blood Clot

The hemostatic efficiency of mesoporous silica nanoparticles depends on pore size more than particle size, and biocompatibility is more related to particle size.

Mesoporous Silica Nanoparticles with Controllable Pore Size: Preparation and Drug Release

2013 ◽  
Vol 774-776 ◽  
pp. 536-539
Author(s):  
Yang Wang ◽  
Yan Shan ◽  
Ke Zheng Chen ◽  
Lian Gao
Keyword(s):  
Electron Microscopy ◽  
Particle Size ◽  
Mesoporous Silica ◽  
Pore Size ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Mesoporous Silica Nanoparticles ◽  
High Specific Surface Area ◽  
Transmission Electron ◽  
Uniform Particle Size

Mesoporous silica nanoparticles (MSNs), with controllable pore size at wider range (2-13 nm) and particle size about 100 nm, have been successfully prepared using different templates. N2 adsorptiondesorption isotherms, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to characterize the material. The results showed that the MSNs have high specific surface area, controllable pore-size and the pore volume, and uniform particle size. Their drug delivery properties were investigated. It was found that the amount of loading DOX is increased with surface area, and the multi-release experiments showed that they had a sustained-release property; MSNs with larger pore size had the larger amount of DOX.

scholarly journals Effects of pore size on in vitro and in vivo anticancer efficacies of mesoporous silica nanoparticles

RSC Advances ◽  
2018 ◽  
Vol 8 (43) ◽  
pp. 24633-24640 ◽  
Author(s):  
Jie Li ◽  
Suqin Shen ◽  
Fei Kong ◽  
Ting Jiang ◽  
Cui Tang ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Pore Size ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Pore Sizes

MSN with suitable pore sizes achieved an outstanding performance for in vitro and in vivo antitumor efficacies.

scholarly journals Controlling Particle Size and Structural Properties of Mesoporous Silica Nanoparticles Using the Taguchi Method

2011 ◽  
Vol 115 (27) ◽  
pp. 13158-13165 ◽  
Author(s):  
Ya-Dong Chiang ◽  
Hong-Yuan Lian ◽  
Sin-Yen Leo ◽  
Shy-Guey Wang ◽  
Yusuke Yamauchi ◽  
...  
Keyword(s):  
Particle Size ◽  
Mesoporous Silica ◽  
Taguchi Method ◽  
Silica Nanoparticles ◽  
Structural Properties ◽  
Mesoporous Silica Nanoparticles

scholarly journals Size Effect of Mesoporous Silica Nanoparticles on Pesticide Loading, Release, and Delivery in Cucumber Plants

2021 ◽  
Vol 11 (2) ◽  
pp. 575
Author(s):  
Yongbing Xu ◽  
Chunli Xu ◽  
Qiliang Huang ◽  
Lidong Cao ◽  
Feifei Teng ◽  
...  
Keyword(s):  
Particle Size ◽  
Mesoporous Silica ◽  
Size Effect ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Research Work ◽  
Control Release ◽  
Carbon Quantum Dots ◽  
Particle Sizes ◽  
Effective Utilization

Mesoporous silica nanoparticles (MSN) are widely used as pesticide carriers to enhance their effective utilization, since it can promote the solubility and absorption of pesticides by plants. For plants, the particle size of pesticides influences their absorption and efficacy. Herein, is our research work of the size effect of MSN on the loading, release, and delivery behavior of pyraoxystrobin (Pyr) in cucumber plants. The well-ordered Pyr-loaded carbon quantum dots-MSN (Pyr@M) with sizes of 15, 100, and 200 nm were prepared. A comparative study among different particle sizes of Pyr@M was carried out on the aspects of control release performance, loading content, uptake, and transportation performance in cucumber plants. It was found that the loading content increased as the particle size increased. The nanoparticles as carriers increased the solubility of insoluble Pyr, but the nanoparticle size had no clear difference impact on the release rate. The efficiency of the cellular uptake strongly depended on the particle size. The smaller the MSN size, the easier it was to be absorbed and transmitted by cucumber plants. Compared to the free Pyr, the upward transportation rate of Pyr from Pyr@M in plant increased by 3.5 times. These findings provide new theoretical basis to design the MSN pesticide delivery system.

scholarly journals Surface functionality density regulated in situ reduction of nanosilver on hierarchial wrinkled mesoporous silica nanoparticles and their antibacterial activity

RSC Advances ◽  
2018 ◽  
Vol 8 (35) ◽  
pp. 19420-19425 ◽  
Author(s):  
Xuejuan Wan ◽  
Lisi Wu ◽  
Hang Pei ◽  
Haoqi Ke ◽  
Guanghui Yang ◽  
...  
Keyword(s):  
Particle Size ◽  
Antibacterial Activity ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Antibacterial Properties ◽  
In Situ Reduction ◽  
Surface Functionality

Nanosilver with diverse particle size was attached onto hierarchical WMS, and the resulted samples showed excellent antibacterial properties.

scholarly journals DESIGN AND DEVELOPMENT OF LULICONAZOLE LOADED MESOPOROUS SILICA NANOPARTICLES AS HYDROGEL FOR MYCOTIC DISEASES

2021 ◽  
Vol 10 (4) ◽  
pp. 3148-3153
Author(s):  
Aachal Anil Gosavi
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
High Surface Area ◽  
Specific Area ◽  
Water Soluble ◽  
Drug Dissolution

The aim of the present work was to design and synthesize of mesoporous silica nanoparticles as topical hydrogel formulation for inclusion of poorly water soluble antifungal drug like Luliconazole as a drug delivery platform. The SBA-15 was prepared to evaluate its application as a carrier for Luliconazole drug delivery. Its molecular size was suitable for incorporation in to the mesoporous of the SBA-15 materials. The SBA-15 was characterized by FTIR, UV analysis, Particle size, Transmission electron microscopy. The Synthesized Mesoporous silica i.e. SBA-15 was of mean particle size of 15 nm and specific area 283.763m2/g respectively. The results revealed that prepared mesoporous silica have small particle size, high surface area, and enhanced drug dissolution rate. The results obtained showed that Luliconazole was loaded with great efficiency into the SBA-15 which leads to enhanced diffusion of drug. Luliconazole hydrogel formulations improved medication permeation across the skin appropriate polymer was used to produce the formulation (Carbopol 934p and HPMC). The physiochemical parameters of all the established luliconazole formulations were assessed, including gel appearance, pH, viscosity, spreadability, globule size, Zeta potential, and drug content. Many of the above parameters yielded positive outcomes but F1 and F3 batch results was were unacceptable ranges. It can be assumed that the formulation F1 and F3 resulted in improved spreadability, stability, and homogeneity, as well as a stronger drug release analysis.

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