Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anions

2016 ◽  
Vol 4 (44) ◽  
pp. 7092-7100 ◽  
Author(s):  
Tonya D. Andreeva ◽  
Hanna Hartmann ◽  
Stefka G. Taneva ◽  
Rumen Krastev
Keyword(s):  
Mechanical Properties ◽  
Physicochemical Properties ◽  
Polyelectrolyte Multilayers ◽  
Growth Morphology ◽  
Natural Polysaccharide ◽  
Hofmeister Anions

Herein the optimization of the physicochemical properties and surface biocompatibility of polyelectrolyte multilayers of the natural, biocompatible and biodegradable, linear polysaccharides hyaluronan and chitosan by Hofmeister anions was systematically investigated.

scholarly journals Is Dialdehyde Chitosan a Good Substance to Modify Physicochemical Properties of Biopolymeric Materials?

2021 ◽  
Vol 22 (7) ◽  
pp. 3391
Author(s):  
Sylwia Grabska-Zielińska ◽  
Alina Sionkowska ◽  
Ewa Olewnik-Kruszkowska ◽  
Katarzyna Reczyńska ◽  
Elżbieta Pamuła
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Physicochemical Properties ◽  
Silk Fibroin ◽  
Three Dimensional ◽  
Microscopy Imaging ◽  
Maximum Deformation ◽  
One Step ◽  
Chitosan Blends ◽  
Fourier Transfer Infrared Spectroscopy

The aim of this work was to compare physicochemical properties of three dimensional scaffolds based on silk fibroin, collagen and chitosan blends, cross-linked with dialdehyde starch (DAS) and dialdehyde chitosan (DAC). DAS was commercially available, while DAC was obtained by one-step synthesis. Structure and physicochemical properties of the materials were characterized using Fourier transfer infrared spectroscopy with attenuated total reflectance device (FTIR-ATR), swelling behavior and water content measurements, porosity and density observations, scanning electron microscopy imaging (SEM), mechanical properties evaluation and thermogravimetric analysis. Metabolic activity with AlamarBlue assay and live/dead fluorescence staining were performed to evaluate the cytocompatibility of the obtained materials with MG-63 osteoblast-like cells. The results showed that the properties of the scaffolds based on silk fibroin, collagen and chitosan can be modified by chemical cross-linking with DAS and DAC. It was found that DAS and DAC have different influence on the properties of biopolymeric scaffolds. Materials cross-linked with DAS were characterized by higher swelling ability (~4000% for DAS cross-linked materials; ~2500% for DAC cross-linked materials), they had lower density (Coll/CTS/30SF scaffold cross-linked with DAS: 21.8 ± 2.4 g/cm3; cross-linked with DAC: 14.6 ± 0.7 g/cm3) and lower mechanical properties (maximum deformation for DAC cross-linked scaffolds was about 69%; for DAS cross-linked scaffolds it was in the range of 12.67 ± 1.51% and 19.83 ± 1.30%) in comparison to materials cross-linked with DAC. Additionally, scaffolds cross-linked with DAS exhibited higher biocompatibility than those cross-linked with DAC. However, the obtained results showed that both types of scaffolds can provide the support required in regenerative medicine and tissue engineering. The scaffolds presented in the present work can be potentially used in bone tissue engineering to facilitate healing of small bone defects.

Feasible strategies to promote the sensing performances of spinel MCo2O4 (M = Ni, Fe, Mn, Cu and Zn) based electrochemical sensors: A review

2021 ◽  
Author(s):  
Josué M. Gonçalves ◽  
Diego Pessoa Rocha ◽  
Murillo N.T. Silva ◽  
Paulo Roberto Martins ◽  
Edson Nossol ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Physicochemical Properties ◽  
Electrochemical Sensors ◽  
Combined Effects ◽  
Cu And Zn

Spinel MCo2O4 (M = Ni, Fe, Mn, Cu and Zn) demonstrates excellent physicochemical properties due to combined effects of M2+ and Co2+ cations. Their inimitable optical, electronic, and mechanical properties...

scholarly journals Enhancing the mechanical properties and cytocompatibility of magnesium potassium phosphate cement by incorporating oxygen-carboxymethyl chitosan

2020 ◽  
Author(s):  
Changtian Gong ◽  
Shuo Fang ◽  
Kezhou Xia ◽  
Jingteng Chen ◽  
Liangyu Guo ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Compressive Strength ◽  
Physicochemical Properties ◽  
Bone Cement ◽  
Ph Value ◽  
Setting Time ◽  
Potassium Phosphate ◽  
Carboxymethyl Chitosan ◽  
Bioactive Substances ◽  
Magnesium Potassium Phosphate Cement

Abstract Incorporating bioactive substances into synthetic bioceramic scaffolds is challenging. In this work, oxygen-carboxymethyl chitosan (O-CMC), a natural biopolymer that is nontoxic, biodegradable and biocompatible, was introduced into magnesium potassium phosphate cement (K-struvite) to enhance its mechanical properties and cytocompatibility. This study aimed to develop O-CMC/magnesium potassium phosphate composite bone cement (OMPC), thereby combining the optimum bioactivity of O-CMC with the extraordinary self-setting properties and mechanical intensity of the K-struvite. Our results indicated that O-CMC incorporation increased the compressive strength and setting time of K-struvite and decreased its porosity and pH value. Furthermore, OMPC scaffolds remarkably improved the proliferation, adhesion and osteogenesis related differentiation of MC3T3-E1 cells. Therefore, O-CMC introduced suitable physicochemical properties to K-struvite and enhanced its cytocompatibility for use in bone regeneration.

scholarly journals Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods

2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Cheng Zhang ◽  
Romain Grossier ◽  
Nadine Candoni ◽  
Stéphane Veesler
Keyword(s):  
Mechanical Properties ◽  
Physicochemical Properties ◽  
Ease Of Use ◽  
Narrow Size Distribution ◽  
Future Perspectives ◽  
Alginate Hydrogel ◽  
Hydrogel Microparticles ◽  
Potential Applications ◽  
Excellent Control ◽  
On Chip

AbstractThis review examines the preparation of alginate hydrogel microparticles by using droplet-based microfluidics, a technique widely employed for its ease of use and excellent control of physicochemical properties, with narrow size distribution. The gelation of alginate is realized “on-chip” and/or “off-chip”, depending on where cross-linkers are introduced. Various strategies are described and compared. Microparticle properties such as size, shape, concentration, stability and mechanical properties are discussed. Finally, we consider future perspectives for the preparation of hydrogel microparticles and their potential applications.

Molecular Architecture of Natural Polysaccharide Based Thin Films

2016 ◽  
Vol 258 ◽  
pp. 358-361 ◽  
Author(s):  
Yuliya V. Chudinova ◽  
Denis V. Kurek ◽  
Valery P. Varlamov
Keyword(s):  
Thin Films ◽  
Mechanical Properties ◽  
Atomic Force Microscopy ◽  
Surface Structure ◽  
Molecular Architecture ◽  
Nanostructured Films ◽  
Thin Coatings ◽  
Force Microscopy ◽  
Atomic Force ◽  
Natural Polysaccharide

Natural biodegradable and biocompatible polysaccharides chitosan, pectin, carrageenan and heparin were used to form thin nanostructured films. In this study using atomic force microscopy (AFM) and force spectroscopy the special characteristics of formation and structure of thin coatings were investigated, three models of the polymers interaction were proposed. Different mechanisms of polymers influence on each other in the bilayers formation were shown, coatings with different surface structure and mechanical properties were formed. The obtained data can be used for the preparation of nanostructured coatings with desired surface parameters.

scholarly journals New crosslinkers for electrospun chitosan fibre mats. I. Chemical analysis

2012 ◽  
Vol 9 (75) ◽  
pp. 2551-2562 ◽  
Author(s):  
Marjorie S. Austero ◽  
Amalie E. Donius ◽  
Ulrike G. K. Wegst ◽  
Caroline L. Schauer
Keyword(s):  
Electron Microscopy ◽  
Mechanical Properties ◽  
Scanning Electron Microscopy ◽  
Mechanical Stability ◽  
Dissolution Tests ◽  
Natural Polysaccharide ◽  
Biomedical Field ◽  
The Stability ◽  
Scanning Electron

Chitosan (CS), the deacetylated form of chitin, the second most abundant, natural polysaccharide, is attractive for applications in the biomedical field because of its biocompatibility and resorption rates, which are higher than chitin. Crosslinking improves chemical and mechanical stability of CS. Here, we report the successful utilization of a new set of crosslinkers for electrospun CS. Genipin, hexamethylene-1,6-diaminocarboxysulphonate (HDACS) and epichlorohydrin (ECH) have not been previously explored for crosslinking of electrospun CS. In this first part of a two-part publication, we report the morphology, determined by field emission scanning electron microscopy (FESEM), and chemical interactions, determined by Fourier transform infrared microscopy, respectively. FESEM revealed that CS could successfully be electrospun from trifluoroacetic acid with genipin, HDACS and ECH added to the solution. Diameters were 267 ± 199 nm, 644 ± 359 nm and 896 ± 435 nm for CS–genipin, CS–HDACS and CS–ECH, respectively. Short- (15 min) and long-term (72 h) dissolution tests (T 600 ) were performed in acidic, neutral and basic pHs (3, 7 and 12). Post-spinning activation by heat and base to enhance crosslinking of CS–HDACS and CS–ECH decreased the fibre diameters and improved the stability. In the second part of this publication, we report the mechanical properties of the fibres.

scholarly journals Change of Graphene with Various Strategies for Photocatalytic Applications: A Review

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Whon Chun Oh
Keyword(s):  
Mechanical Properties ◽  
Physicochemical Properties ◽  
H2 Production ◽  
Thermal And Mechanical Properties ◽  
2D Structure ◽  
Photocatalytic Applications

Because of its novel molecular 2D structure and momentous physicochemical properties, graphene has been started a whirlwind of the investigation into its optical, electronic, thermal, and mechanical properties. Specifically, a lot of considerations have been pulled in to investigate graphene and graphene composites for photoelectrochemical applications. Many works have been done to synthesize novel graphene-based materials for applications in photoelectrochemistry, such as photoelectrochemical sunlight-based cells, photocatalytic disintegration of natural contaminations, and H2 production. In this article, we abridge the condition of research on graphene-based materials for photoelectrochemistry. The prospects and further improvements in this energizing field of graphene-based materials are additionally discussed. A B S T R A KKarena struktur 2D dan keunggulan karakteristik fisika-kimia, graphene telah mulai diselidiki secara menyeluruh terhadap sifat optik, elektronik, panas, dan mekanik. Secara khusus, focus dipelukan untuk menyelidiki graphene dan komposit graphene untuk aplikasi fotoelektrokimia. Banyak studi dikerjakan untuk membuat material baru berbasis graphene untuk aplikasi fotoelektrokimia seperti photoelectrochemical sunlight-based cells, fotokatalitik untuk penghilangan kontaminan, dan produksi H2. Pada artikel ini akan disumarisasikan penelitian-penelitian terkait material berbasis graphene untuk aplikasi fotoelektrokimia. Harapan dan perkembangan aplikasi penggunaan material berbasis graphene juga didiskusikan.

scholarly journals Preparation of Multicomponent Biocomposites and Characterization of Their Physicochemical and Mechanical Properties

2020 ◽  
Vol 4 (1) ◽  
pp. 18
Author(s):  
Yuriy A. Anisimov ◽  
Duncan E. Cree ◽  
Lee D. Wilson
Keyword(s):  
Mechanical Properties ◽  
Electrical Conductivity ◽  
Physicochemical Properties ◽  
In Situ Polymerization ◽  
Structural Parameters ◽  
Dye Adsorption ◽  
Mechanical Analysis ◽  
Scanning Calorimetry ◽  
Swelling Properties

This work focused on a mutual comparison and characterization of the physicochemical properties of three-component polymer composites. Binary polyaniline–chitosan (PANI–CHT) composites were synthesized by in situ polymerization of PANI onto CHT. Ternary composites were prepared by blending with a third component, polyvinyl alcohol (PVA). Composites with variable PANI:CHT (25:75, 50:50 and 75:25) weight ratios were prepared whilst fixing the composition of PVA. The structure and physicochemical properties of the composites were evaluated using thermal analysis (thermogravimetric analysis (TGA), differential scanning calorimetry (DSC)) and spectroscopic methods (infrared (IR), nuclear magnetic resonance (NMR)). The equilibrium and dynamic adsorption properties of composites were evaluated by solvent swelling in water, water vapour adsorption and dye adsorption isotherms. The electrical conductivity was estimated using current–voltage curves. The mechanical properties of the samples were evaluated using dynamic mechanical analysis (DMA) and correlated with the structural parameters of the composites. The adsorption and swelling properties paralleled the change in the electrical and mechanical properties of the materials. In most cases, samples with higher content of chitosan exhibit higher adsorption and mechanical properties, and lower conductivity. Acid-doped samples showed much higher adsorption, swelling, and electrical conductivity than their undoped analogues.

scholarly journals Effect of Substrate Stiffness on Physicochemical Properties of Normal and Fibrotic Lung Fibroblasts

Materials ◽  
2020 ◽  
Vol 13 (20) ◽  
pp. 4495
Author(s):  
Joanna Raczkowska ◽  
Barbara Orzechowska ◽  
Sabina Patryas ◽  
Kamil Awsiuk ◽  
Andrzej Kubiak ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Physicochemical Properties ◽  
Chemical Properties ◽  
Principal Component ◽  
Lung Fibroblasts ◽  
Substrate Stiffness ◽  
Significant Difference ◽  
The Impact

The presented research aims to verify whether physicochemical properties of lung fibroblasts, modified by substrate stiffness, can be used to discriminate between normal and fibrotic cells from idiopathic pulmonary fibrosis (IPF). The impact of polydimethylsiloxane (PDMS) substrate stiffness on the physicochemical properties of normal (LL24) and IPF-derived lung fibroblasts (LL97A) was examined in detail. The growth and elasticity of cells were assessed using fluorescence microscopy and atomic force microscopy working in force spectroscopy mode, respectively. The number of fibroblasts, as well as their shape and the arrangement, strongly depends on the mechanical properties of the substrate. Moreover, normal fibroblasts remain more rigid as compared to their fibrotic counterparts, which may indicate the impairments of IPF-derived fibroblasts induced by the fibrosis process. The chemical properties of normal and IPF-derived lung fibroblasts inspected using time-of-flight secondary ion mass spectrometry, and analyzed complexly with principal component analysis (PCA), show a significant difference in the distribution of cholesterol and phospholipids. Based on the observed distinctions between healthy and fibrotic cells, the mechanical properties of cells may serve as prospective diagnostic biomarkers enabling fast and reliable identification of idiopathic pulmonary fibrosis (IPF).

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