A multifunctional core–shell nanoplatform for enhanced cancer cell apoptosis and targeted chemotherapy

2016 ◽  
Vol 4 (17) ◽  
pp. 2887-2894 ◽  
Author(s):  
Fei Zhou ◽  
Tingting Zheng ◽  
E. S. Abdel-Halim ◽  
Liping Jiang ◽  
Jun-Jie Zhu
Keyword(s):  
Silver Nanoparticles ◽  
Manganese Dioxide ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Core Shell ◽  
Targeted Chemotherapy ◽  
Cancer Cell Apoptosis

A novel multifunctional nanoplatform was designed based on the combination of silver nanoparticles (AgNPs) with nucleolin-targeted and doxorubicin (Dox)-loaded manganese dioxide (MnO2) nanosheets to induce enhanced cancer cell apoptosis and targeted chemotherapy.

scholarly journals Counterion coupled (COCO) gemini surfactant capped Ag/Au alloy and core–shell nanoparticles for cancer therapy

RSC Advances ◽  
2019 ◽  
Vol 9 (65) ◽  
pp. 37830-37845 ◽  
Author(s):  
A. Mohammed Siddiq ◽  
Ramar Thangam ◽  
Balaraman Madhan ◽  
Md. Sayem Alam
Keyword(s):  
Dna Damage ◽  
Cancer Therapy ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Gemini Surfactant ◽  
Au Nanoparticles ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Cancer Cell Apoptosis ◽  
Core Shell Nanoparticles

In this work hybrid silver (Ag)–gold (Au) nanoparticles (NPs) with different sizes and compositions were synthesized and applied for anticancer evaluations and which is effectively involved in cancer cell apoptosis through DNA damage.

scholarly journals Core–Shell Nanoparticle-Based Peptide Therapeutics and Combined Hyperthermia for Enhanced Cancer Cell Apoptosis

ACS Nano ◽  
2014 ◽  
Vol 8 (9) ◽  
pp. 9379-9387 ◽  
Author(s):  
Birju P. Shah ◽  
Nicholas Pasquale ◽  
Gejing De ◽  
Tao Tan ◽  
Jianjie Ma ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Apoptosis ◽  
Core Shell ◽  
Peptide Therapeutics ◽  
Cancer Cell Apoptosis

Caging of plumbagin on silver nanoparticles imparts selectivity and sensitivity to plumbagin for targeted cancer cell apoptosis

Metallomics ◽  
2014 ◽  
Vol 6 (11) ◽  
pp. 2025-2033 ◽  
Author(s):  
N. Duraipandy ◽  
Rachita Lakra ◽  
Srivatsan Kunnavakkam Vinjimur ◽  
Debasis Samanta ◽  
Purna Sai K ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cancer Cell Apoptosis

Nano-caging of plumbagin for selective killing of cancer cells.

Synthesis of double mesoporous core–shell silica spheres with tunable core porosity and their drug release and cancer cell apoptosis properties

2012 ◽  
Vol 378 (1) ◽  
pp. 83-92 ◽  
Author(s):  
Ahmed Mohamed El-Toni ◽  
Aslam Khan ◽  
Mohamed Abbas Ibrahim ◽  
Joselito Puzon Labis ◽  
Gamal badr ◽  
...  
Keyword(s):  
Drug Release ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Core Shell ◽  
Silica Spheres ◽  
Cancer Cell Apoptosis

scholarly journals Histone methyltransferase WHSC1 inhibits colorectal cancer cell apoptosis via targeting anti-apoptotic BCL2

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yu Wang ◽  
Liming Zhu ◽  
Mei Guo ◽  
Gang Sun ◽  
Kun Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
B Cell Lymphoma ◽  
Histone Methyltransferase ◽  
Chemotherapeutic Agents ◽  
Cancer Cell Apoptosis ◽  
Active Transcription

AbstractWHSC1 is a histone methyltransferase that facilitates histone H3 lysine 36 dimethylation (H3K36me2), which is a permissive mark associated with active transcription. In this study, we revealed how WHSC1 regulates tumorigenesis and chemosensitivity of colorectal cancer (CRC). Our data showed that WHSC1 as well as H3K36me2 were highly expressed in clinical CRC samples, and high WHSC1 expression is associated with poorer prognosis in CRC patients. WHSC1 reduction promoted colon cancer cell apoptosis both in vivo and in vitro. We found that B cell lymphoma-2 (BCL2) expression, an anti-apoptotic protein, is markedly decreased in after WHSC1 depletion. Mechanistic characterization indicated that WHSC1 directly binds to the promoter region of BCL2 gene and regulate its H3K36 dimethylation level. What’s more, our study indicated that WHSC1 depletion promotes chemosensitivity in CRC cells. Together, our results suggested that WHSC1 and H3K36me2 modification might be optimal therapeutic targets to disrupt CRC progression and WHSC1-targeted therapy might potentially overcome the resistance of chemotherapeutic agents.

Saccharomyces cerevisiae may serve as a probiotic in colorectal cancer by promoting cancer cell apoptosis

2020 ◽  
Vol 21 (10) ◽  
pp. 571-582
Author(s):  
Jia Qi Li ◽  
Jia Lu Li ◽  
Yuan Hong Xie ◽  
Yao Wang ◽  
Xiao Nan Shen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Saccharomyces Cerevisiae ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cancer Cell Apoptosis

scholarly journals Selective degradation of IKKα by autophagy is essential for arsenite-induced cancer cell apoptosis

2020 ◽  
Vol 11 (4) ◽  
Author(s):  
Qixing Tan ◽  
Shuxian Zou ◽  
Rui Jin ◽  
Yongliang Hu ◽  
Huan Xu ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Apoptosis ◽  
Selective Degradation ◽  
Cancer Cell Apoptosis

scholarly journals β-hydroxyisovaleryl-shikonin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling

2015 ◽  
Vol 10 (6) ◽  
pp. 3434-3442 ◽  
Author(s):  
DAN LU ◽  
JING QIAN ◽  
WEI LI ◽  
QIANQIAN FENG ◽  
SHU PAN ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Mtor Signaling ◽  
Cervical Cancer Cell ◽  
Cancer Cell Apoptosis ◽  
Human Cervical Cancer Cell ◽  
Human Cervical Cancer
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